Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Eric Krump"'
Suppressive effects of adenosine on the 5-lipoxygenase pathway in human polymorphonuclear leukocytes
Autor:
Michelle Austin, Hendrick Plante, Marc E. Surette, Eric Krump, Serge Picard, Pierre Borgeat, Nicolas Flamand, Sylvain G. Bourgoin
Publikováno v:
Drug Development Research. 52:397-405
Leukotrienes are potent mediators of inflammation and host defense. They are also involved in inflammatory and allergic diseases. While numerous studies have investigated the stimulatory mechanisms of leukotriene biosynthesis in phagocytes by inflamm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bcb6a036d2ab444f04a2b5a775d98c3d
https://doi.org/10.1002/ddr.1140
https://doi.org/10.1002/ddr.1140
Autor:
Thomas F. Lindsay, David A. Ford, Paul Walker, Barry B. Rubin, Gregory P. Downey, Peihong Zhu, Eric Krump, John Marshall
Publikováno v:
The Journal of Immunology. 164:2084-2091
The purpose of this study was to define the role of secretory phospholipase A2 (sPLA2), calcium-independent PLA2, and cytosolic PLA2 (cPLA2) in arachidonic acid (AA) release from fMLP-stimulated human neutrophils. While fMLP induced the release of ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7daead460446f8ea0a8cbf32263f3ca
https://doi.org/10.4049/jimmunol.164.4.2084
https://doi.org/10.4049/jimmunol.164.4.2084
Publikováno v:
The Journal of Experimental Medicine
Adenosine (Ado) has been shown to suppress several functional responses of human polymorphonuclear leukocytes (PMNs). The current study investigated whether endogenous Ado regulates the biosynthesis of leukotriene (LT)B4 in ligand-stimulated PMNs. Me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4caf7822edc3553bce3fee98dcd61ed6
https://doi.org/10.1084/jem.186.8.1401
https://doi.org/10.1084/jem.186.8.1401
Publikováno v:
Journal of Biological Chemistry. 272:17303-17311
The ubiquitous isoform of the Na+/H+ exchanger (NHE1) is essential for the regulation of cellular volume. The underlying molecular mechanism, which is poorly understood, was studied in human polymorphonuclear leukocytes (PMN). Suspension of PMN in hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::061d57b3c9cc5602e5792ef7b94e9bfe
https://doi.org/10.1074/jbc.272.28.17303
https://doi.org/10.1074/jbc.272.28.17303
Publikováno v:
British Journal of Pharmacology. 117:1639-1644
1. Engagement of adenosine A2 receptors suppresses several leukocyte functions. In the present study, we examined the effect of adenosine on the inhibition of leukotriene B4 (LTB4) synthesis in heparinized human whole blood, pretreated with lipopolys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c81bcfdb97a5e2d8ae692f1e0c3a38e9
https://doi.org/10.1111/j.1476-5381.1996.tb15334.x
https://doi.org/10.1111/j.1476-5381.1996.tb15334.x
Autor:
Gaétan P. L'Heureux, Eric Krump, Sylvain G. Bourgoin, Alain Richard, Shaun R. McColl, Paul H. Naccache, Guy Pelletier
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 1299:259-266
Activated sphingomyelinases release ceramide molecules believed to be involved in intracellular signalling. The present study investigated whether soluble C2-ceramide modulates some of the effects of N-formylmethionylleucyl phenylalanine (fMLP) and o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22ec790f1f087e6ceccb8123746b7a9b
https://doi.org/10.1016/0005-2760(95)00215-4
https://doi.org/10.1016/0005-2760(95)00215-4
Autor:
Eric Krump, Pierre Borgeat
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 1213:135-139
The kinetics of 5-lipoxygenase (5-LO) activation in human neutrophils was compared with that of arachidonic acid (AA) release and leukotriene (LT) B4 synthesis, and the effect of granulocyte-macrophage colony-stimulating factor (GM-CSF) on these proc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02537bd66f14ac420a419003ae66477b
https://doi.org/10.1016/0005-2760(94)90019-1
https://doi.org/10.1016/0005-2760(94)90019-1
Publikováno v:
Molecular pharmacology. 56(5)
We report here that the apparent inability of isolated human polymorphonuclear leukocytes (PMNs) to efficiently transform arachidonic acid (AA) is the consequence of A(2a) receptor engagement by endogenous adenosine accumulating in incubation media.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3bf60b6805e38713f1963adfe848792
https://pubmed.ncbi.nlm.nih.gov/10531413
https://pubmed.ncbi.nlm.nih.gov/10531413
Autor:
Eric Krump, Pierre Borgeat
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9780306460449
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::877eec4ad414f0726db41d7317f5fd7d
https://doi.org/10.1007/978-1-4615-4861-4_10
https://doi.org/10.1007/978-1-4615-4861-4_10
Publikováno v:
The American journal of physiology. 275(4)
Although used extensively for the measurement of intracellular pH, derivatives of fluorescein such as 2′,7′-bis(2-carboxyethyl)-5(6)-carboxyfluorescein (BCECF) have suboptimal sensitivity and can generate toxic photoproducts. These limitations ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c474e5f374a6a312cd4cc2ce5f117bb8
https://pubmed.ncbi.nlm.nih.gov/9755070
https://pubmed.ncbi.nlm.nih.gov/9755070