Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Eric Kowarz"'
Autor:
Raquel S. Pereira, Rahul Kumar, Alessia Cais, Lara Paulini, Alisa Kahler, Jimena Bravo, Valentina R. Minciacchi, Theresa Krack, Eric Kowarz, Costanza Zanetti, Parimala Sonika Godavarthy, Fabian Hoeller, Pablo Llavona, Tabea Stark, Georg Tascher, Daniel Nowak, Eshwar Meduri, Brian J. P. Huntly, Christian Münch, Francesco Pampaloni, Rolf Marschalek, Daniela S. Krause
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Haematopoietic stem cells (HSC) reside in the bone marrow microenvironment (BMM), where they respond to extracellular calcium [eCa2+] via the G-protein coupled calcium-sensing receptor (CaSR). Here we show that a calcium gradient exists in t
Externí odkaz:
https://doaj.org/article/00699074cde14bba837f1807407edcf5
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106900- (2023)
Summary: Chromosomal translocations (CTs) are a genetic hallmark of cancer. They could be identified as recurrent genetic aberrations in hemato-malignancies and solid tumors. More than 40% of all “cancer genes” were identified in recurrent CTs. M
Externí odkaz:
https://doaj.org/article/3a1ad7840fd04b67b8b9e7e0b50ab895
Publikováno v:
Cell & Bioscience, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Background Recent pathomolecular studies on the MLL-AF4 fusion protein revealed that the murinized version of MLL-AF4, the MLL-Af4 fusion protein, was able to induce leukemia when expressed in murine or human hematopoietic stem/progenitor ce
Externí odkaz:
https://doaj.org/article/2ce8290080a74f20a5345ea76e29f05a
Autor:
Eric Kowarz, Lea Krutzke, Marius Külp, Patrick Streb, Patrizia Larghero, Jennifer Reis, Silvia Bracharz, Tatjana Engler, Stefan Kochanek, Rolf Marschalek
Publikováno v:
eLife, Vol 11 (2022)
To fight the COVID-19 pandemic caused by the RNA virus SARS-CoV-2, a global vaccination campaign is in progress to achieve the immunization of billions of people mainly with adenoviral vector- or mRNA-based vaccines, all of which encode the SARS-CoV-
Externí odkaz:
https://doaj.org/article/30a61e87efa345b19c61d8c01cdaf176
Autor:
Virginia C Rodriguez-Cortez, Maria Pilar Navarrete-Meneses, Oscar Molina, Talia Velasco-Hernandez, Jessica Gonzalez, Paola Romecin, Francisco Gutierrez-Aguera, Heleia Roca-Ho, Meritxell Vinyoles, Eric Kowarz, Pedro Marin, Sandra Rodriguez-Perales, Carlos Gomez-Marin, Patricia Perez-Vera, Felipe Cortes-Ledesma, Anna Bigas, Andrea Terron, Clara Bueno, Pablo Menendez
Publikováno v:
Haematologica, Vol 107, Iss 2 (2021)
Externí odkaz:
https://doaj.org/article/263476971eba4a109551d512d852e371
Autor:
Marek Widera, Alexander Wilhelm, Tuna Toptan, Johanna M. Raffel, Eric Kowarz, Fabian Roesmann, Finn Grözinger, Anna Lena Siemund, Vanessa Luciano, Marius Külp, Jennifer Reis, Silvia Bracharz, Christiane Pallas, Sandra Ciesek, Rolf Marschalek
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the acute respiratory disease COVID-19, which has become a global concern due to its rapid spread. The common methods to monitor and quantitate SARS-CoV-2 infe
Externí odkaz:
https://doaj.org/article/1a997f31bb6e40b395fdee9f642c9d83
Autor:
Amelie Tjaden, Apirat Chaikuad, Eric Kowarz, Rolf Marschalek, Stefan Knapp, Martin Schröder, Susanne Müller
Publikováno v:
Molecules, Vol 27, Iss 4, p 1439 (2022)
Phenotypical screening is a widely used approach in drug discovery for the identification of small molecules with cellular activities. However, functional annotation of identified hits often poses a challenge. The development of small molecules with
Externí odkaz:
https://doaj.org/article/20c97fc2b80e4721bacc784466d8503a
Autor:
Samaneh Sabiani, Tim Geppert, Christian Engelbrecht, Eric Kowarz, Gisbert Schneider, Rolf Marschalek
Publikováno v:
EBioMedicine, Vol 2, Iss 5, Pp 386-395 (2015)
We have recently demonstrated that Taspase1-mediated cleavage of the AF4–MLL oncoprotein results in the formation of a stable multiprotein complex which forms the key event for the onset of acute proB leukemia in mice. Therefore, Taspase1 represent
Externí odkaz:
https://doaj.org/article/e10aa6f20fc14131b4b5cc0b94e1acb9
Autor:
Rahul Kumar, Raquel S. Pereira, Julian Niemann, Alexander I. Azimpour, Costanza Zanetti, Christina Karantanou, Wahyu Minka, Valentina R. Minciacchi, Eric Kowarz, Melanie Meister, Parimala S. Godavarthy, Véronique Maguer-Satta, Sylvain Lefort, Eliza Wiercinska, Halvard Bonig, Rolf Marschalek, Daniela S. Krause
Publikováno v:
Blood Advances. 6:3611-3624
Lipid raft-associated proteins play a vital role in membrane-mediated processes. The lipid microdomain-associated protein flotillin 2 (FLOT2), which has a scaffolding function, is involved in polarization, as well as in actin cytoskeletal organizatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b194023761ce92b0b3a09fa45a7eabeb
https://doi.org/10.1182/bloodadvances.2021005992
https://doi.org/10.1182/bloodadvances.2021005992
Autor:
Müller, Amelie Tjaden, Apirat Chaikuad, Eric Kowarz, Rolf Marschalek, Stefan Knapp, Martin Schröder, Susanne
Publikováno v:
Molecules; Volume 27; Issue 4; Pages: 1439
Phenotypical screening is a widely used approach in drug discovery for the identification of small molecules with cellular activities. However, functional annotation of identified hits often poses a challenge. The development of small molecules with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::64dc74661b0ede93e41e6dd30b25d5dd