Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Eric Kenneth Parkinson"'
Publikováno v:
Molecular Oncology, Vol 16, Iss 8, Pp 1625-1649 (2022)
Alterations of the Hippo–YAP pathway are potential targets for oral squamous cell carcinoma (OSCC) therapy, but heterogeneity in this pathway could be responsible for therapeutic resistance. We analysed the Hippo–YAP signatures in a cohort of cha
Externí odkaz:
https://doaj.org/article/f6b3c64eea6f4670b6cbc92bfc7981c6
Publikováno v:
Frontiers in Dental Medicine, Vol 3 (2022)
Cellular senescence is an irreversible cell cycle arrest occurring following multiple rounds of cell division (replicative senescence) or in response to cellular stresses such as ionizing radiation, signaling imbalances and oxidative damage (stress-i
Externí odkaz:
https://doaj.org/article/2b449faeabb34790b15c3b32e92a4921
Autor:
Yunying Huang, Hana Jedličková, Yang Cai, Ambreen Rehman, Luke Gammon, Usama Sharif Ahmad, Jutamas Uttagomol, Eric Kenneth Parkinson, Farida Fortune, Hong Wan
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Pemphigus Vulgaris (PV) is a life-threatening autoimmune disease manifested with blisters in the skin and mucosa and caused by autoantibodies against adhesion protein desmoglein-3 (Dsg3) expressed in epithelial membrane linings of these tissues. Desp
Externí odkaz:
https://doaj.org/article/d552e93411844ce6a68f4dd42c302970
Publikováno v:
Cancer Letters. 518:102-114
This study reviews the molecular landscape of oral potentially malignant disorders (OPMD). We examine the impact of tumour heterogeneity, the spectrum of driver mutations (TP53, CDKN2A, TERT, NOTCH1, AJUBA, PIK3CA, CASP8) and gene transcription on tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98044664d20b685652838b7959b19c5d
https://doi.org/10.1016/j.canlet.2021.05.025
https://doi.org/10.1016/j.canlet.2021.05.025
Autor:
Lee Peng Karen-Ng, Usama Sharif Ahmad, Luis Gomes, Keith David Hunter, Hong Wan, Eleni Hagi-Pavli, Eric Kenneth Parkinson
Publikováno v:
Cancers; Volume 14; Issue 11; Pages: 2636
Potentially pre-malignant lesions (PPOLs) are composed of keratinocytes that are either mortal (MPPOL) or immortal (IPPOL) in vitro. We report here that MPPOL, but not generally IPPOL keratinocytes upregulate various extracellular tumor promoting cyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27ba3473082ab818901e361c871525e4
https://doi.org/10.1101/2022.03.10.483769
https://doi.org/10.1101/2022.03.10.483769
Telomerase deficiency in humans is associated with systemic age-related changes in energy metabolism
Autor:
Emma Naomi James, Virag Sagi-Kiss, Mark Bennett, Maria Mycielska, Karen-Ng Lee Peng, Terry Roberts, Sheila Matta, Inderjeet Dokal, Jacob Guy Bundy, Eric Kenneth Parkinson
SUMMARYUnderlying mechanisms of plasma metabolite signatures of human ageing and age-related diseases are not clear but telomere attrition and dysfunction are central to both. Dyskeratosis Congenita (DC) is associated with mutations in the telomerase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb985c37c1cebb51f33556c8770e6788
https://doi.org/10.1101/2022.02.28.481982
https://doi.org/10.1101/2022.02.28.481982
Publikováno v:
International journal of molecular sciences. 23(7)
Recent mouse model experiments support an instrumental role for senescent cells in age-related diseases and senescent cells may be causal to certain age-related pathologies. A strongly supported hypothesis is that extranuclear chromatin is recognized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc52cf604b0ba5f7282740e830dfed5f
https://pubmed.ncbi.nlm.nih.gov/35409012
https://pubmed.ncbi.nlm.nih.gov/35409012
Autor:
Abish S. Stephen, Eric Kenneth Parkinson, Emma L. James, Mark H. Bennett, Lee Peng Karen-Ng, Maria E. Mycielska
Publikováno v:
Cancers
Cancers, Vol 13, Iss 4212, p 4212 (2021)
Volume 13
Issue 16
Cancers, Vol 13, Iss 4212, p 4212 (2021)
Volume 13
Issue 16
Simple Summary The early detection of oral cancer is a high priority, as improvements in this area could lead to greater cure rates and reduced disability due to extensive surgery. Oral cancer is very difficult to detect in over 70% of cases as it de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3974e0cd1a0383a5303e3e3e90abe105
http://europepmc.org/articles/PMC8394991
http://europepmc.org/articles/PMC8394991
Publikováno v:
Dental materials : official publication of the Academy of Dental Materials. 37(10)
Objective Resin-modified glass ionomer cements (RMGICs) present several advantages (e.g. fluoride release), but their reported cytotoxicity has been associated with hydroxyethyl methacrylate (HEMA) monomer release. Therefore, different monomers were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91bbf73cbebfaa47f677b84a141babc6
https://pubmed.ncbi.nlm.nih.gov/34462139
https://pubmed.ncbi.nlm.nih.gov/34462139