Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Eric K. Lau"'
Autor:
Qian Liu, Emma Adhikari, Daniel K. Lester, Bin Fang, Joseph O. Johnson, Yijun Tian, Andrea T. Mockabee-Macias, Victoria Izumi, Kelly M. Guzman, Michael G. White, John M. Koomen, Jennifer A. Wargo, Jane L. Messina, Jianfei Qi, Eric K. Lau
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Melanoma incidence and mortality rates are historically higher for men than women. Although emerging studies have highlighted tumorigenic roles for the male sex hormone androgen and its receptor (AR) in melanoma, cellular and molecular mecha
Externí odkaz:
https://doaj.org/article/1d6b5538888248d5b44646f3fe07e1be
Autor:
Chase Burton, Amirreza Bitaraf, Kara Snyder, Chaomei Zhang, Sean J. Yoder, Dorina Avram, Dongliang Du, Xiaoqing Yu, Eric K. Lau
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Despite significant advances in the development and refinement of immunotherapies administered to combat cancer over the past decades, a number of barriers continue to limit their efficacy. One significant clinical barrier is the inability to mount i
Externí odkaz:
https://doaj.org/article/b44b5811fe744928a418000792b9fe16
Autor:
Emma Adhikari, Qian Liu, Joseph Johnson, Paul Stewart, Viktoriya Marusyk, Bin Fang, Victoria Izumi, Kiah Bowers, Kelly M. Guzman, John M. Koomen, Andriy Marusyk, Eric K. Lau
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113463- (2023)
Summary: Brain metastasis cancer-associated fibroblasts (bmCAFs) are emerging as crucial players in the development of breast cancer brain metastasis (BCBM), but our understanding of the underlying molecular mechanisms is limited. In this study, we a
Externí odkaz:
https://doaj.org/article/c94698fc17e54b619ec84e1ff20702ab
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Fat and Dachsous are large cadherins that regulate planar polarity as a receptor:ligand pair. Here, authors determine the structure of the Fat:Dachsous complex to uncover the molecular determinants of binding and posttranslational modification.
Externí odkaz:
https://doaj.org/article/26c914ba27a3409fbe4efea1685f878a
Autor:
Didem Ilter, Stanislav Drapela, Tanya Schild, Nathan P. Ward, Emma Adhikari, Vivien Low, John Asara, Thordur Oskarsson, Eric K. Lau, Gina M. DeNicola, Melanie R. McReynolds, Ana P. Gomes
Publikováno v:
Redox Biology, Vol 61, Iss , Pp 102627- (2023)
Metabolic reprogramming and metabolic plasticity allow cancer cells to fine-tune their metabolism and adapt to the ever-changing environments of the metastatic cascade, for which lipid metabolism and oxidative stress are of particular importance. NAD
Externí odkaz:
https://doaj.org/article/e2c33671c9844c32a8eea52be1ef6e6d
Autor:
Daniel K. Lester, Chase Burton, Alycia Gardner, Patrick Innamarato, Krithika Kodumudi, Qian Liu, Emma Adhikari, Qianqian Ming, Daniel B. Williamson, Dennie T. Frederick, Tatyana Sharova, Michael G. White, Joseph Markowitz, Biwei Cao, Jonathan Nguyen, Joseph Johnson, Matthew Beatty, Andrea Mockabee-Macias, Matthew Mercurio, Gregory Watson, Pei-Ling Chen, Susan McCarthy, Carlos MoranSegura, Jane Messina, Kerry L. Thomas, Lancia Darville, Victoria Izumi, John M. Koomen, Shari A. Pilon-Thomas, Brian Ruffell, Vincent C. Luca, Robert S. Haltiwanger, Xuefeng Wang, Jennifer A. Wargo, Genevieve M. Boland, Eric K. Lau
Publikováno v:
Nature Cancer. 4:222-239
Despite reports of striking outcomes, immunotherapy efficacy in melanoma is limited to subsets of patients 1, 2. Combining immunotherapies with other modalities has yielded limited improvements but also adverse events requiring cessation of treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a64da195ce606f3ff385fc17153f645
https://doi.org/10.1038/s43018-022-00506-7
https://doi.org/10.1038/s43018-022-00506-7
Autor:
Keiran S.M. Smalley, Jonathan D. Licht, Lixin Wan, Eric K. Lau, Yian A. Chen, John M. Koomen, Vernon K. Sondak, Edward Seto, Dirk Schadendorf, Jurgen C. Becker, Jane L. Messina, Ram Thapa, Ritin Sharma, Fernanda Faião-Flores, Michael F. Emmons
Melanoma cells have the ability to switch to a dedifferentiated, invasive phenotype in response to multiple stimuli. Here, we show that exposure of melanomas to multiple stresses including BRAF–MEK inhibitor therapy, hypoxia, and UV irradiation lea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5da52b92a487e5dcfb81b8d1851fac0d
https://doi.org/10.1158/0008-5472.c.6510969.v1
https://doi.org/10.1158/0008-5472.c.6510969.v1
Autor:
Keiran S.M. Smalley, Jonathan D. Licht, Lixin Wan, Eric K. Lau, Yian A. Chen, John M. Koomen, Vernon K. Sondak, Edward Seto, Dirk Schadendorf, Jurgen C. Becker, Jane L. Messina, Ram Thapa, Ritin Sharma, Fernanda Faião-Flores, Michael F. Emmons
Supplementary Table 1: Clinical data on samples stained for HDAC8 expression. S1) HDAC expression levels in melanoma cells S2) Cell lines that are resistant to BRAF inhibitors have upregulated c-Jun protein expression S3) Inhibiting HDAC6 does not re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc6ffdbbb57cbf9a3fbf4aae51306ce3
https://doi.org/10.1158/0008-5472.22421604
https://doi.org/10.1158/0008-5472.22421604
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0199128 (2018)
The fucose salvage pathway is a two-step process in which mammalian cells transform L-fucose into GDP-L-fucose, a universal fucose donor used by fucosyltransferases to modify glycans. Emerging evidence indicates the fucose salvage pathway and the fuc
Externí odkaz:
https://doaj.org/article/bce9ec354b884d98b346ead5d4688645