Výsledky vyhledávání - "Eric K. Hoobler"

Akademický článek

Discovery of a novel dual fungal CYP51/human 5-lipoxygenase inhibitor: implications for anti-fungal therapy.

Autor: Eric K Hoobler, Ganesha Rai, Andrew G S Warrilow, Steven C Perry, Christopher J Smyrniotis, Ajit Jadhav, Anton Simeonov, Josie E Parker, Diane E Kelly, David J Maloney, S L Kelly, Theodore R Holman

Publikováno v: PLoS ONE, Vol 8, Iss 6, p e65928 (2013)

We report the discovery of a novel dual inhibitor targeting fungal sterol 14α-demethylase (CYP51 or Erg11) and human 5-lipoxygenase (5-LOX) with improved potency against 5-LOX due to its reduction of the iron center by its phenylenediamine core. A s

Externí odkaz: https://doaj.org/article/7993a077535548118bd36c4560fa1ddb

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Discovery of Potent and Selective Inhibitors of Human Reticulocyte 15-Lipoxygenase-1

Autor: Lena Schultz, William Leister, Eric K. Hoobler, Ganesha Rai, David J. Maloney, Ajit Jadhav, Anton Simeonov, Victor Kenyon, J. Brian Jameson, Theodore R. Holman, Michelle Armstrong

Publikováno v: Journal of Medicinal Chemistry. 53:7392-7404

There are a variety of lipoxygenases in the human body (hLO), each having a distinct role in cellular biology. Human reticulocyte 15-Lipoxygenase-1 (15-hLO-1), which catalyzes the dioxygenation of 1,4-cis,cis-pentadiene-containing polyunsaturated fat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cafaab2347c925f5459749999db50e5
https://doi.org/10.1021/jm1008852

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Using Enzyme Assays to Evaluate the Structure and Bioactivity of Sponge-Derived Meroterpenes

Autor: Eric K. Hoobler, Karen Tenney, Sarah J. Robinson, Theodore R. Holman, Michelle Riener, Frederick A. Valeriote, Phillip Crews, Steven T. Loveridge

Publikováno v: Journal of Natural Products. 72:1857-1863

Enzyme screening of crude sponge extracts prioritized a 2005 Papua New Guinea collection of Hyrtios sp. for further study. The MeOH extract contained puupehenone and four puupehenone analogues (1, 2, 3, 5, and 7) along with a new diastereomer, 20-epi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e776b1645bcb6629b5adebf4e129f82
https://doi.org/10.1021/np900465e

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Enzymatic Studies of Isoflavonoids as Selective and Potent Inhibitors of Human Leukocyte 5-Lipo-Oxygenase

Autor: Silvia Sepúlveda-Boza, Eric K. Hoobler, Theodore R. Holman, Carolina Mascayano, Giovanni Diaz, Victoria Espinosa, Steve Perry

Publikováno v: Chem Biol Drug Des
Chemical biology & drug design, vol 86, iss 1
Mascayano, C; Espinosa, V; Sepúlveda-Boza, S; Hoobler, EK; Perry, S; Diaz, G; et al.(2015). Enzymatic studies of isoflavonoids as selective and potent inhibitors of human leukocyte 5-lipo-oxygenase. Chemical Biology and Drug Design, 86(1), 894-901. doi: 10.1111/cbdd.12469. UC Santa Cruz: Retrieved from: http://www.escholarship.org/uc/item/7mk9465q

© 2014 John Wiley & Sons A/S. Continuing our search to find more potent and selective 5-LOX inhibitors, we present now the enzymatic evaluation of seventeen isoflavones (IR) and nine isoflavans (HIR), and their in vitro and in cellulo potency agains

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9638ae7a3280637b0ba4932cf39e39bd
https://pubmed.ncbi.nlm.nih.gov/25359714

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KINETIC AND STRUCTURAL INVESTIGATIONS INTO THE ALLOSTERIC AND PH EFFECT ON SUBSTRATE SPECIFICITY OF HUMAN EPITHELIAL 15-LIPOXYGENASE-2

Autor: Theodore R. Holman, Giovanni Diaz, Eric K. Hoobler, Netra Joshi, Brian G. Fox, Steve Perry

Lipoxygenases, important enzymes in inflammation, can regulate their substrate specificity by allosteric interactions with its own hydroperoxide products. In the current work, addition of both 13-(S) hydroxy-9Z,11E-octadecadienoic acid (13-(S)-HODE)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::360894b0e2b1779b161f5d14d06cebb8
https://europepmc.org/articles/PMC3866584/

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Discovery of a Novel Dual Fungal CYP51/Human 5-Lipoxygenase Inhibitor: Implications for Anti-Fungal Therapy

Autor: Diane E. Kelly, Andrew G. S. Warrilow, Ganesha Rai, Eric K. Hoobler, Steven L. Kelly, Theodore R. Holman, Ajit Jadhav, David J. Maloney, Josie E. Parker, Anton Simeonov, Christopher J. Smyrniotis, Steve Perry

Publikováno v: PLoS ONE
PLoS ONE, Vol 8, Iss 6, p e65928 (2013)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4f644e841e113549f48d38bc9b255ac
http://europepmc.org/articles/PMC3691235

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PSEUDOPEROXIDASE INVESTIGATIONS OF HYDROPEROXIDES AND INHIBITORS WITH HUMAN LIPOXYGENASES

Autor: Theodore R. Holman, Eric K. Hoobler, Charles Holz

Understanding the mode of action for lipoxygenase (LOX) inhibitors is critical to determining their efficacy in the cell. The pseudoperoxidase assay is an important tool for establishing if a LOX inhibitor is reductive in nature, however, there have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2ddf6396816a1882b35c3636297371c
https://europepmc.org/articles/PMC3781013/

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In vitro study of isoflavones and isoflavans as potent inhibitors of human 12- and 15-lipoxygenases

Autor: Silvia Sepúlveda-Boza, Victoria Espinosa, Steve Perry, Eric K. Hoobler, Carolina Mascayano

Publikováno v: CHEMICAL BIOLOGY & DRUG DESIGN
Artículos CONICYT
CONICYT Chile
instacron:CONICYT

In this study, we have investigated 16 isoflavone and isoflavan derivatives as potential inhibitors of human lipoxygenase (platelet 12-lipoxygenase, reticulocyte 15-lipoxygenase-1, and epithelial 15-lipoxygenase-2). The flavonoid baicalein, a known l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d9d0a192ffedf243ab34ec0d25c041d
https://pubmed.ncbi.nlm.nih.gov/23663316

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