Výsledky vyhledávání - "Eric K. Crawford"

The Role of 3′ Poly(A) Tail Metabolism in Tumor Necrosis Factor-α Regulation

Autor: Eric K. Crawford, Jeffrey D. Hasday, J. E. Ensor, Indira Kalvakolanu

Publikováno v: Journal of Biological Chemistry. 272:21120-21127

In unstimulated RAW 264.7 macrophage-like cells, tumor necrosis factor-alpha (TNF-alpha) mRNA was transcribed and accumulated in the cytoplasm, but the TNF-alpha transcripts failed to associate with polysomes, and TNF-alpha protein was not detected.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92d823b09fa11461b72e2c204b7c2f06
https://doi.org/10.1074/jbc.272.34.21120

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Warming macrophages to febrile range destabilizes tumor necrosis factor-alpha mRNA without inducing heat shock

Autor: Eric K. Crawford, Jeffrey D. Hasday, J. E. Ensor

Publikováno v: American Journal of Physiology-Cell Physiology. 269:C1140-C1146

We have previously reported that sustained tumor necrosis factor (TNF)-alpha expression is suppressed by temperatures in the febrile range in human macrophages. In this study, we examined the mechanisms of high-temperature-induced macrophage TNF supp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8593e3aa6b84fd49307415f514b51db
https://doi.org/10.1152/ajpcell.1995.269.5.c1140

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Differential effects of hyperthermia on macrophage interleukin-6 and tumor necrosis factor-alpha expression

Autor: Rose M. Viscardi, Eric K. Crawford, J. E. Ensor, S. M. Wiener, Jeffrey D. Hasday, K. A. McCrea

Publikováno v: American Journal of Physiology-Cell Physiology. 266:C967-C974

The pyrogenic cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) appear in the circulation during infections and injuries, but TNF-alpha and IL-6 are regulated differently in macrophages. We compared the effects of elevated te

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e158953fb5771f68567087500ea4d2ee
https://doi.org/10.1152/ajpcell.1994.266.4.c967

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Effects of assay medium composition on macrophage-mediated tumor cell binding and lysis

Autor: Jeffrey D. Hasday, Eric K. Crawford

Publikováno v: Journal of Immunological Methods. 114:243-252

Activated macrophages express selective, high avidity tumor binding and cytotoxicity for tumor targets. The reported macrophage-mediated tumor binding and killing activities vary considerably among studies. Whereas, some of these studies utilized ide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f565e9c268c27085bc608198ffafda1a
https://doi.org/10.1016/0022-1759(88)90180-9

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