Výsledky vyhledávání

Akademický článek

Histone H4K20 methylation mediated chromatin compaction threshold ensures genome integrity by limiting DNA replication licensing

Autor: Muhammad Shoaib, David Walter, Peter J. Gillespie, Fanny Izard, Birthe Fahrenkrog, David Lleres, Mads Lerdrup, Jens Vilstrup Johansen, Klaus Hansen, Eric Julien, J. Julian Blow, Claus S. Sørensen

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)

Cell cycle and replication need to be tightly regulated to ensure genome stability in mammalian cells. Here the authors provide a link between chromatin structure and DNA replication regulation by showing that chromatin compaction limits replication

Externí odkaz: https://doaj.org/article/8099256713994c5ea367ade824604648

Zobrazit plný text záznamu

Akademický článek

The Transcription Factor E4F1 Coordinates CHK1-Dependent Checkpoint and Mitochondrial Functions

Autor: Geneviève Rodier, Olivier Kirsh, Martín Baraibar, Thibault Houlès, Matthieu Lacroix, Hélène Delpech, Elodie Hatchi, Stéphanie Arnould, Dany Severac, Emeric Dubois, Julie Caramel, Eric Julien, Bertrand Friguet, Laurent Le Cam, Claude Sardet

Publikováno v: Cell Reports, Vol 11, Iss 2, Pp 220-233 (2015)

Recent data support the notion that a group of key transcriptional regulators involved in tumorigenesis, including MYC, p53, E2F1, and BMI1, share an intriguing capacity to simultaneously regulate metabolism and cell cycle. Here, we show that another

Externí odkaz: https://doaj.org/article/750ec7fa7c584a56a4679e3138ac001f

Zobrazit plný text záznamu

Akademický článek

Epigenetic regulation of histone H3 serine 10 phosphorylation status by HCF-1 proteins in C. elegans and mammalian cells.

Autor: Soyoung Lee, Virginie Horn, Eric Julien, Yi Liu, Joanna Wysocka, Bruce Bowerman, Michael O Hengartner, Winship Herr

Publikováno v: PLoS ONE, Vol 2, Iss 11, p e1213 (2007)

The human herpes simplex virus (HSV) host cell factor HCF-1 is a transcriptional coregulator that associates with both histone methyl- and acetyltransferases, and a histone deacetylase and regulates cell proliferation and division. In HSV-infected ce

Externí odkaz: https://doaj.org/article/af2f666d23394f43ae05dd245cf4f774

Zobrazit plný text záznamu

Non-commitment in mental imagery

Autor: Eric Julien Bigelow, John McCoy, Tomer David Ullman

Publikováno v: Cognition. 238:105498

We examine non-commitment in the imagination. Across 5 studies (N > 1, 800), we find that most people are non-committal about basic aspects of their mental images, including features that would be readily apparent in real images. While previous work

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7598e27f9c0157a16ed53f15f1f946a1
https://doi.org/10.1016/j.cognition.2023.105498

Zobrazit plný text záznamu

The mouse HP1 proteins are essential for preventing liver tumorigenesis

Autor: Marine Pratlong, Eric Fabbrizio, Lakdhar Khellaf, Nelly Pirot, Amélie Sarrazin, Damien Grégoire, Yannick Perez, Shefqet Hajdari, Jean-Yohan Noël, Eric Julien, Nehmé Saksouk, Aliki Zavoriti, Florence Cammas, Céline Graber, Célia Barrachina

Publikováno v: Oncogene
Oncogene, Nature Publishing Group, 2020, 39 (13), pp.2676-2691. ⟨10.1038/s41388-020-1177-8⟩

International audience; Chromatin organization is essential for appropriate interpretation of the genetic information. Here, we demonstrated that the chromatin associated proteins HP1 are dispensable for hepatocytes survival but are essential within

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::261f982476fcd05a475d58373edb93fb
https://doi.org/10.1038/s41388-020-1177-8

Zobrazit plný text záznamu

Targeting the methyltransferase SETD8 impairs tumor cell survival and overcomes drug resistance independently of p53 status in multiple myeloma

Autor: Eric Julien, Jian Jin, Claire Gourzones, Fanny Izard, Laurie Herviou, Celine Bellanger, Elke De Bruyne, Karin Vanderkerken, Guillaume Cartron, Charlotte Grimaud, Ouissem Karmous-Gadacha, Anqi Ma, Laure Vincent, Jérôme Moreaux, Eva Desmedt

Publikováno v: Clinical Epigenetics
Clinical Epigenetics, BioMed Central, 2021, 13 (1), ⟨10.1186/s13148-021-01160-z⟩
BioRxiv
BioRxiv, In press, ⟨10.1101/776930⟩
Clinical Epigenetics, 2021, 13 (1), ⟨10.1186/s13148-021-01160-z⟩

Background Multiple myeloma (MM) is a malignancy of plasma cells that largely remains incurable. The search for new therapeutic targets is therefore essential. In addition to a wide panel of genetic mutations, epigenetic alterations also appear as im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c091bc5491bdcecafba2c967100f616d
https://doi.org/10.1101/776930

Zobrazit plný text záznamu

The mouse HP1 proteins are essential for preventing liver tumorigenesis

Autor: Nehmé, Saksouk, Shefqet, Hajdari, Yannick, Perez, Marine, Pratlong, Célia, Barrachina, Céline, Graber, Damien, Grégoire, Aliki, Zavoriti, Amélie, Sarrazin, Nelly, Pirot, Jean-Yohan, Noël, Lakhdar, Khellaf, Eric, Fabbrizio, Eric, Julien, Florence M, Cammas

Publikováno v: Oncogene. 39(13)

Chromatin organization is essential for appropriate interpretation of the genetic information. Here, we demonstrated that the chromatin-associated proteins HP1 are dispensable for hepatocytes survival but are essential within hepatocytes to prevent l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8d590e9afe6a5505ad43994bd91171c4
https://pubmed.ncbi.nlm.nih.gov/32020053

Zobrazit plný text záznamu

Histone H4K20 methylation mediated chromatin compaction threshold ensures genome integrity by limiting DNA replication licensing

Autor: Eric Julien, Fanny Izard, Klaus Hansen, Jens Vilstrup Johansen, Mads Lerdrup, David Llères, Birthe Fahrenkrog, Muhammad Shoaib, David Walter, Claus Storgaard Sørensen, J. Julian Blow, Peter J. Gillespie

Publikováno v: Nature communications, 9 (1
Shoaib, M, Walter, D, Gillespie, P J, Izard, F, Fahrenkrog, B, Lleres, D, Lerdrup, M, Johansen, J V, Hansen, K, Julien, E, Blow, J J & Sørensen, C S 2018, ' Histone H4K20 methylation mediated chromatin compaction threshold ensures genome integrity by limiting DNA replication licensing ', Nature Communications, vol. 9, no. 1, 3704, pp. 1-11 . https://doi.org/10.1038/s41467-018-06066-8
Nature Communications
Nature Communications, Nature Publishing Group, 2018, 9, pp.3704. ⟨10.1038/s41467-018-06066-8⟩
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Nature Communications, 2018, 9, pp.3704. ⟨10.1038/s41467-018-06066-8⟩

The decompaction and re-establishment of chromatin organization immediately after mitosis is essential for genome regulation. Mechanisms underlying chromatin structure control in daughter cells are not fully understood. Here we show that a chromatin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67f5e427615bf9141aad98cd7784b0cb
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/282441

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání