Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Eric Jervis"'
Publikováno v:
International Journal of Biomedical Imaging, Vol 2006 (2006)
The study of cell behavior is of crucial importance in drug and disease research. The fields of bioinformatics and biotechnology rely on the collection, processing, and analysis of huge numbers of biocellular images, including cell features such as c
Externí odkaz:
https://doaj.org/article/57869f58bfef4ff98ae4d1d57445e807
Autor:
David Lillicrap, Curtis Woodford, J. Guy Guillemette, Eric Jervis, Sandeep T. Koshy, Jim W. E. Rush, Bredon Crawford, Chistine M. Thompson, Geeta Jhamb, Andrew S. Levy
Publikováno v:
The Canadian Journal of Chemical Engineering. 90:1457-1464
Perfusion decellularisation is a promising technique in scaffold production for tissue engineering. The similarity of decellularised extracellular matrix to native matrix is attractive for the development of compatible and functional constructs for t
Publikováno v:
Cancer Research. 78:5015-5015
Three-dimensional (3D) cell culture models provide more physiologically relevant drug and toxicity screening platforms than traditional 2D platforms (1). Phenotypic analysis is an informative endpoint for high-throughput screens; however, variability
Autor:
Sarah de Groot, Jeremy Bezaire, Jason Yaeck, Christine How, Tim Rasmusson, Eric Jervis, J. Guy Guillemette, Gary I. Dmitrienko, Geneviève Labbé
Publikováno v:
Protein Expression and Purification. 51:110-119
The Class II fructose 1,6-bisphosphate aldolase from the Rice Blast causative agent Magnaporthe grisea was subcloned in the Escherichia coli vector pT7-7. The enzyme was overexpressed using fed-batch fermentation in a small bench-top reactor. A total
Autor:
Eric Jervis, Connie J. Eaves, John Ramunas, April Blaylock, David G. Kent, Brad Dykstra, Erin Szumsky, Liam Kelly, Kristen Farn, Lindsay McCaffrey
Publikováno v:
Proceedings of the National Academy of Sciences. 103:8185-8190
To search for new indicators of self-renewing hematopoietic stem cells (HSCs), highly purified populations were isolated from adult mouse marrow, micromanipulated into a specially designed microscopic array, and cultured for 4 days in 300 ng/ml Steel
Autor:
Phillip, Karpowicz, Cindi, Morshead, Angela, Kam, Eric, Jervis, John, Ramunas, John, Ramuns, Vincent, Cheng, Derek, van der Kooy
Publikováno v:
Biological Sciences Publications
The Journal of Cell Biology
The Journal of Cell Biology
The immortal strand hypothesis proposes that asymmetrically dividing stem cells (SCs) selectively segregate chromosomes that bear the oldest DNA templates. We investigated cosegregation in neural stem cells (NSCs). After exposure to the thymidine ana
Publikováno v:
Analytical Biochemistry. 332:122-136
Several systematic errors may occur during the analysis of uninhibited enzyme kinetic data using commercially available multiwell plate reader software. A MATLAB program is developed to remove these systematic errors from the data analysis process fo
Autor:
Heather J. Montgomery, Basil Perdicakis, Eric Jervis, J. Guy Guillemette, Thomas C. Squier, Ryan K. Bartlett
Publikováno v:
Biochemistry. 42:7759-7768
Several calmodulin (CaM) mutants were engineered in an effort to identify the functional implications of the oxidation of individual methionines in CaM on the activity of the constitutive isoforms of nitric oxide synthase(NOS). Site-directed mutagene
Autor:
Basil Perdicakis, Heather J. Montgomery, Dan Fishlock, J. Guy Guillemette, Eric Jervis, Gilles A. Lajoie
Publikováno v:
Bioorganic & Medicinal Chemistry. 11:869-873
Four optically pure conformationally restricted L-arginine analogues syn- 1 and anti- 2 trans-3,4-cyclopropyl L-arginine, and syn- 3 and anti-trans-3,4-cyclopropyl N-(1-iminoethyl) L-ornithine 4 were synthesized. These compounds were tested as potent
Autor:
Dan Fishlock, Basil Perdicakis, Gilles A. Lajoie, Heather J. Montgomery, J. Guy Guillemette, Eric Jervis
Publikováno v:
Bioorganic & Medicinal Chemistry. 10:1919-1927
Nitric oxide (NO) plays a critical role in a number of physiological processes and is produced in mammalian cells by nitric oxide synthase (NOS) isozymes. Because of the diverse functions of NO, pharmaceutical interventions which seek to abrogate adv