A mouse model of humanized liver shows a human-like lipid profile, but does not form atherosclerotic plaque after western type diet

Autor: Andre Boonstra, Maikel P. Peppelenbosch, Jeanine E. Roeters van Lennep, Gulce Sari, Kim van der Heiden, Leonie C. van Vark-van der Zee, Kristiaan Wouters, Monique T. Mulder, Thomas Vanwolleghem, Eric Jan Meester

Publikováno v: Biochemical and Biophysical Research Communications, 524, 510-515. Academic Press
Biochemical and Biophysical Research Communications, 524(2), 510-515. Elsevier
Biochemical and biophysical research communications

Mouse models are a crucial and often used tool to provide insight into the underlying mechanisms of human atherosclerosis. However, mice profoundly differ from humans in lipoprotein synthesis and metabolism, key factors in atherosclerotic plaque form

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https://pure.eur.nl/en/publications/9c8b51c8-4b65-40d4-bbd2-3c2a1f4c3db0