Zobrazeno 1 - 10
of 146
pro vyhledávání: '"Eric Jakobsson"'
Autor:
Ton E Becker, Eric Jakobsson
Publikováno v:
Journal of Biomedical Semantics, Vol 12, Iss 1, Pp 1-10 (2021)
Abstract Background The revolution in molecular biology has shown how protein function and structure are based on specific sequences of amino acids. Thus, an important feature in many papers is the mention of the significance of individual amino acid
Externí odkaz:
https://doaj.org/article/4fb2e8e2467d4e63b21f42714edb8a12
Autor:
Ashok Palaniappan, Eric Jakobsson
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 15, Iss , Pp 265-270 (2017)
Residue conservation is a common observation in alignments of protein families, underscoring positions important in protein structure and function. Though many methods measure the level of conservation of particular residue positions, currently we do
Externí odkaz:
https://doaj.org/article/654877bebfc34abca647f96777307077
Autor:
Weihao Ge, Eric Jakobsson
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Lithium has many widely varying biochemical and phenomenological effects, suggesting that a systems biology approach is required to understand its action. Multiple lines of evidence point to lithium as a significant factor in development of cancer, s
Externí odkaz:
https://doaj.org/article/682032305acf49d29335455c2a8a5b33
Publikováno v:
Frontiers in Applied Mathematics and Statistics, Vol 5 (2019)
Background: A central question in bioinformatics is how to minimize arbitrariness and bias in analysis of patterns of enrichment in data. A prime example of such a question is enrichment of gene ontology (GO) classes in lists of genes. Our paper deal
Externí odkaz:
https://doaj.org/article/457138fe23864d83a5e7eacbca10eefd
Autor:
Seyfullah Kotil, Eric Jakobsson
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0209894 (2019)
Antisense molecules used as antibiotics offer the potential to keep up with acquired resistance, by redesigning the sequence of an antisense. Once bacteria acquire resistance by mutating the targeted sequence, new antisense can readily be designed by
Externí odkaz:
https://doaj.org/article/69818530a25549bbb4334b84e304cdec
Systems Biology Understanding of the Effects of Lithium on Affective and Neurodegenerative Disorders
Autor:
Weihao Ge, Eric Jakobsson
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
Lithium has many widely varying biochemical and phenomenological effects, suggesting that a systems biology approach is required to understand its action. Multiple lines of evidence point to lithium intake and consequent blood levels as important det
Externí odkaz:
https://doaj.org/article/57d8fe3c2d8a4e189a0039c84f90347f
Publikováno v:
Life, Vol 5, Iss 1, Pp 214-229 (2015)
Various protocell models have been constructed de novo with the bottom-up approach. Here we describe a silica-based protocell composed of a nanoporous amorphous silica core encapsulated within a lipid bilayer built by self-assembly that provides for
Externí odkaz:
https://doaj.org/article/14949533663d4aed80270039ec7d9501
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 6, p e1004921 (2016)
The emerging field of sociogenomics explores the relations between social behavior and genome structure and function. An important question is the extent to which associations between social behavior and gene expression are conserved among the Metazo
Externí odkaz:
https://doaj.org/article/17f588eedcce499bb055b9c645bf097b
Autor:
Tae-Jin Kim, Chirlmin Joo, Jihye Seong, Reza Vafabakhsh, Elliot L Botvinick, Michael W Berns, Amy E Palmer, Ning Wang, Taekjip Ha, Eric Jakobsson, Jie Sun, Yingxiao Wang
Publikováno v:
eLife, Vol 4 (2015)
It is unclear that how subcellular organelles respond to external mechanical stimuli. Here, we investigated the molecular mechanisms by which mechanical force regulates Ca2+ signaling at endoplasmic reticulum (ER) in human mesenchymal stem cells. Wit
Externí odkaz:
https://doaj.org/article/414e53f260df4d20812b6dbf45a7bdbf
Autor:
Hua Zhou, Eric Jakobsson
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e81100 (2013)
Molecular co-evolution analysis as a sequence-only based method has been used to predict protein-protein interactions. In co-evolution analysis, Pearson's correlation within the mirrortree method is a well-known way of quantifying the correlation bet
Externí odkaz:
https://doaj.org/article/a9143df4c4fe46e0b3eddfb96d85a5a9