Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Eric J. Hebert"'
Autor:
Lubica Urbanikova, Satoshi Imura, John Landua, J. Martin Scholtz, Bret A. Shirley, C. Nick Pace, D Schell, Saul R. Trevino, Gerald R. Grimsley, Hailong Fu, Jozef Sevcik, Richard L. Thurlkill, Eric J. Hebert, Kazufumi Takano, Ketan S. Gajiwala, Jeffery K. Myers, Katrina Lee Fryar
Publikováno v:
Protein Science. 23:652-661
Our goal was to gain a better understanding of the contribution of the burial of polar groups and their hydrogen bonds to the conformational stability of proteins. We measured the change in stability, Δ(ΔG), for a series of hydrogen bonding mutants
Autor:
Jie Wang, Edmund D. Matayoshi, Edward T. Olejniczak, Ana Pereda-Lopez, Philip J. Hajduk, Liping Yu, Chaohong Sun, Eric J. Hebert, Renaldo Mendoza
Publikováno v:
Protein Science. 16:2502-2509
Calsenilin is a member of the recoverin branch of the EF-hand superfamily that is reported to interact with presenilins, regulate prodynorphin gene expression, modulate voltage-gated Kv4 potassium channel function, and bind to neurotoxins. Calsenilin
Autor:
Tianyuan Zhang, Richard A. G. Smith, Rohinton Edalji, Yu-Gui Gu, John L. Baranowski, William J. Sanders, Bruce A. Beutel, Liping Yu, Philip J. Hajduk, Annapur Gurulingappa Shivakumar, Stephan J. Kakavas, Frank L. Wagenaar, Darlene J. Balli, Steven F. Betz, Richard F. Clark, Kenneth M. Comess, Eric J. Hebert, J. Owen McCall, Jamey Mack, Linda E. Chovan, Randy E. Metzger, Thomas F. Holzman, Anne Y. Saiki, Sarah A. Dorwin, Niru B. Soni, Mai Bui, Angela M. Nilius, Susan J. Thornewell, Cooper Curt S, Mark E. Schurdak, Michael L. Coen, Rolf Wagner, Alan S. Florjancic, Philip J. Merta, Claude G. Lerner, Charlotte Woodall, Candace Black-Schaefer, John E. Harlan, Mengli Cai, Karl A. Walter, Xenia B. Searle, Stephen W. Fesik
Publikováno v:
Chemical Biology & Drug Design. 69:395-404
As part of a fully integrated and comprehensive strategy to discover novel antibacterial agents, NMR- and mass spectrometry-based affinity selection screens were performed to identify compounds that bind to protein targets uniquely found in bacteria
Autor:
C Nick, Pace, Hailong, Fu, Katrina, Lee Fryar, John, Landua, Saul R, Trevino, David, Schell, Richard L, Thurlkill, Satoshi, Imura, J Martin, Scholtz, Ketan, Gajiwala, Jozef, Sevcik, Lubica, Urbanikova, Jeffery K, Myers, Kazufumi, Takano, Eric J, Hebert, Bret A, Shirley, Gerald R, Grimsley
Publikováno v:
Protein science : a publication of the Protein Society. 23(5)
Our goal was to gain a better understanding of the contribution of the burial of polar groups and their hydrogen bonds to the conformational stability of proteins. We measured the change in stability, Δ(ΔG), for a series of hydrogen bonding mutants
Autor:
Robert W. Hartley, Valentin Both, Eric J. Hebert, Dagmar Homerova, Milan Jucovic, Viktor Nazarov, Igor Rybajhak, Jozef Sevcik
Publikováno v:
Protein & Peptide Letters. 3:225-231
Abstract: Barstar, the intracellular protein of Bacillus amyloliquefaciens which binds to and inhibits barnase, the extracellular ribonuclease of the same organism, has been found to bind to and inhibit also the homologous ribonucleases of several St
Autor:
Thomas F. Holzman, Eric J. Hebert
Publikováno v:
Drug discovery today. 10(1)
Drug discovery has historically advanced by synergy and chance. These are proving insufficient to meet the needs of the marketplace and the demands of modern medicine. We describe our strategic approaches to building and employing flexible informatic
Autor:
William B. Heuer, Mark D. Totten, Gary S. Rodman, Eric J. Hebert, Henry J. Tracy, Jeffrey K. Nagle
Publikováno v:
Journal of the American Chemical Society. 106:1163-1164