Výsledky vyhledávání - "Eric J. Enemark"

Akademický článek

Two Distinct Modes of DNA Binding by an MCM Helicase Enable DNA Translocation

Autor: Martin Meagher, Alexander Myasnikov, Eric J. Enemark

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 23, p 14678 (2022)

A six-subunit ATPase ring forms the central hub of the replication forks in all domains of life. This ring performs a helicase function to separate the two complementary DNA strands to be replicated and drives the replication machinery along the DNA.

Externí odkaz: https://doaj.org/article/a80db5d37a9b4e46ae5b2995ded9fbe9

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Akademický článek

DNA translocation mechanism of the MCM complex and implications for replication initiation

Autor: Martin Meagher, Leslie B. Epling, Eric J. Enemark

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)

Eukaryotes and archaea use a heximeric ring-shaped MCM helicase to unwind the DNA template during replication. Here the authors present a crystal structure of the MCM complex from archaeon S. solfataricus bound to single-stranded DNA, and to a combin

Externí odkaz: https://doaj.org/article/da3d2f86275a48fca8e4523d176c6988

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Akademický článek

Fundamental Characteristics of AAA+ Protein Family Structure and Function

Autor: Justin M. Miller, Eric J. Enemark

Publikováno v: Archaea, Vol 2016 (2016)

Many complex cellular events depend on multiprotein complexes known as molecular machines to efficiently couple the energy derived from adenosine triphosphate hydrolysis to the generation of mechanical force. Members of the AAA+ ATPase superfamily (A

Externí odkaz: https://doaj.org/article/5bd71debe0e54943ad4aaaeeff554167

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Akademický článek

Archaeal MCM Proteins as an Analog for the Eukaryotic Mcm2–7 Helicase to Reveal Essential Features of Structure and Function

Autor: Justin M. Miller, Eric J. Enemark

Publikováno v: Archaea, Vol 2015 (2015)

In eukaryotes, the replicative helicase is the large multisubunit CMG complex consisting of the Mcm2–7 hexameric ring, Cdc45, and the tetrameric GINS complex. The Mcm2–7 ring assembles from six different, related proteins and forms the core of th

Externí odkaz: https://doaj.org/article/b9e5fb164dbd4f7895971dbd5f997b87

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