Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Eric J. Drake"'
Autor:
Andrew M. Gulick, Courtney C. Aldrich, Eric J. Drake, Valeria Guidolin, Evan M. Alexander, Dale F. Kreitler, Alexander K. Hurben, Silvia Balbo, Peter W. Villalta
Publikováno v:
ACS Infect Dis
Tilimycin is an enterotoxin produced by the opportunistic pathogen Klebsiella oxytoca that causes antibiotic-associated hemorrhagic colitis (AAHC). This pyrrolobenzodiazepine (PBD) natural product is synthesized by a bimodular nonribosomal peptide sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::617291f024e10a726790b85acbc53bc6
https://doi.org/10.1021/acsinfecdis.0c00326
https://doi.org/10.1021/acsinfecdis.0c00326
Autor:
Lisa S. Mydy, Eric J. Drake, Andrew M. Gulick, Courtney C. Aldrich, Daniel Bailey, Evan M. Alexander, Matthew R. Rice
Publikováno v:
Journal of Biological Chemistry. 293:7841-7852
Aerobactin, a citryl-hydroxamate siderophore, is produced by a number of pathogenic Gram-negative bacteria to aid in iron assimilation. Interest in this well-known siderophore was reignited by recent investigations suggesting that it plays a key role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a28580dec250c2e84ea6cb1241b84e9
https://doi.org/10.1074/jbc.ra118.002798
https://doi.org/10.1074/jbc.ra118.002798
Publikováno v:
Biochemistry
Iron is a vital mineral nutrient required by virtually all life forms to prosper; pathogenic bacteria are no exception. Despite the abundance of iron within the human host, highly regulated iron physiology can result in exceedingly low levels of iron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2140882d1200ca78e2b25999adb55c7
https://doi.org/10.1021/acs.biochem.6b00409
https://doi.org/10.1021/acs.biochem.6b00409
Autor:
Tina L. Amyes, Kalvin J. Kim, Xiang Zhai, Rik K. Wierenga, Eric J. Drake, Andrew M. Gulick, M. Merced Malabanan, John P. Richard, Christopher J. Reinhardt
Publikováno v:
Biochemistry
Kinetic parameters are reported for the reactions of whole substrates (kcat/Km, M(-1) s(-1)) (R)-glyceraldehyde 3-phosphate (GAP) and dihydroxyacetone phosphate (DHAP) and for the substrate pieces [(kcat/Km)E·HPi/Kd, M(-2) s(-1)] glycolaldehyde (GA)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23da5905987b78ac77644d8c3c9c8d50
http://europepmc.org/articles/PMC4934371
http://europepmc.org/articles/PMC4934371
Autor:
Daniel C, Bailey, Evan, Alexander, Matthew R, Rice, Eric J, Drake, Lisa S, Mydy, Courtney C, Aldrich, Andrew M, Gulick
Publikováno v:
The Journal of biological chemistry. 293(20)
Aerobactin, a citryl-hydroxamate siderophore, is produced by a number of pathogenic Gram-negative bacteria to aid in iron assimilation. Interest in this well-known siderophore was reignited by recent investigations suggesting that it plays a key role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5f07cbc873e2f936abf22ae7276cb5ed
https://pubmed.ncbi.nlm.nih.gov/29618511
https://pubmed.ncbi.nlm.nih.gov/29618511
Autor:
Neil L. Kelleher, Rui Wu, Eric J. Drake, Walter Fast, Dali Liu, Andrew M. Gulick, Kenneth D. Clevenger, Romila Mascarenhas, Daniel S. Catlin
Publikováno v:
ACS chemical biology. 12(3)
Siderophore biosynthesis by Pseudomonas aeruginosa enhances virulence and represents an attractive drug target. PvdQ functions in the type-1 pyoverdine biosynthetic pathway by removing a myristoyl anchor from a pyoverdine precursor, allowing eventual
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::799e2f74a15f8f8128748bcf950d9743
https://pubmed.ncbi.nlm.nih.gov/28186406
https://pubmed.ncbi.nlm.nih.gov/28186406
Autor:
Stuart L. Schreiber, Lynn VerPlank, Sivaraman Dandapani, Ivan T. Jewett, Benito Munoz, Jimmy R. Theriault, Jacqueline Wurst, Andrew M. Gulick, Michelle Palmer, Samuel M. Moskowitz, Eric J. Drake, José Carlos Rodríguez Pérez
Publikováno v:
ACS Chemical Biology
The growing prevalence of drug-resistant bacterial pathogens is of significant concern in the United States and worldwide. Of particular concern are the multidrug resistant Gram-negative bacteria including Klebsiella pneumoniae, Acinetobacter species
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e2cb574052219bff45b2ab010eed72b
https://doi.org/10.1021/cb5001586
https://doi.org/10.1021/cb5001586
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 81:1621-1633
We recently reported the engineering of monomeric streptavidin, mSA, corresponding to one subunit of wild type (wt) streptavidin tetramer. The monomer was designed by homology modeling, in which the streptavidin and rhizavidin sequences were combined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42803de79fc1e83e816a615407b38087
https://doi.org/10.1002/prot.24320
https://doi.org/10.1002/prot.24320
Autor:
Daniel J. Wilson, Curtis A. Engelhart, Eric J. Drake, rd Clifton E. Barry, Andrew M. Gulick, Courtney C. Aldrich, Helena I. Boshoff, João Neres, Peng Fu
Publikováno v:
Journal of Medicinal Chemistry. 56:2385-2405
Siderophores are small-molecule iron chelators produced by bacteria and other microorganisms for survival under iron limiting conditions such as found in a mammalian host. Siderophore biosynthesis is essential for the virulence of many important Gram
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91e0c2d6434e1fbd256dd5528f85b8ae
https://doi.org/10.1021/jm301709s
https://doi.org/10.1021/jm301709s
Publikováno v:
The Journal of biological chemistry. 291(43)
Nonribosomal peptide synthetases (NRPSs) produce a wide variety of peptide natural products. During synthesis, the multidomain NRPSs act as an assembly line, passing the growing product from one module to the next. Each module generally consists of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12d9bb9ae16a687ae94a72ce3b541717
https://pubmed.ncbi.nlm.nih.gov/27597544
https://pubmed.ncbi.nlm.nih.gov/27597544