Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Eric J. Bernhard"'
Autor:
Helen B. Stone, Eric J. Bernhard, C. Norman Coleman, James Deye, Jacek Capala, James B. Mitchell, J. Martin Brown
Publikováno v:
Translational Oncology, Vol 9, Iss 1, Pp 46-56 (2016)
BACKGROUND: Clinical testing of new therapeutic interventions requires comprehensive, high-quality preclinical data. Concerns regarding quality of preclinical data have been raised in recent reports. This report examines the data on the interaction o
Externí odkaz:
https://doaj.org/article/59c43b2a5835475193c79c4ceb8671fb
Autor:
Keith A. Cengel, K. Rahn Voong, Sanjay Chandrasekaran, Laurence Maggiorella, Thomas B. Brunner, Eric Stanbridge, Gary D. Kao, W. Gillies McKenna, Eric J. Bernhard
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 9, Iss 4, Pp 341-348 (2007)
Pancreatic and colorectal carcinomas frequently express oncogenic/mutant K-Ras that contributes to both tumorigenesis and clinically observed resistance to radiation treatment. We have previously shown that farnesyltransferase inhibitors (FTI) radios
Externí odkaz:
https://doaj.org/article/f48a0521806f495baa1a5c443b948ea5
Autor:
Mansoor M. Ahmed, Eric J. Bernhard, Mark W. Dewhirst, Pataje G.S. Prasanna, Henning Willers, David G. Kirsch, Michael Baumann, J. Martin Brown, Geoff S. Higgins, C. Norman Coleman
Illustration of utility of companion canine spontaneous cancer model to address the complexities in preclinical in vivo radiobiological assays
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::063d5cab278ae343dc46d7c210ae6c1b
https://doi.org/10.1158/1078-0432.22463633
https://doi.org/10.1158/1078-0432.22463633
Autor:
Mansoor M. Ahmed, Eric J. Bernhard, Mark W. Dewhirst, Pataje G.S. Prasanna, Henning Willers, David G. Kirsch, Michael Baumann, J. Martin Brown, Geoff S. Higgins, C. Norman Coleman
There is an urgent need to improve reproducibility and translatability of preclinical data to fully exploit opportunities for molecular therapeutics involving radiation and radiochemotherapy. For in vitro research, the clonogenic assay remains the cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4255dcb290151f4cfdc43f0809d83634
https://doi.org/10.1158/1078-0432.c.6525467.v1
https://doi.org/10.1158/1078-0432.c.6525467.v1
Autor:
Mansoor M. Ahmed, Eric J. Bernhard, Mark W. Dewhirst, Pataje G.S. Prasanna, Henning Willers, David G. Kirsch, Michael Baumann, J. Martin Brown, Geoff S. Higgins, C. Norman Coleman
Supplementary Figure S1 Legend from Improving the Predictive Value of Preclinical Studies in Support of Radiotherapy Clinical Trials
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57947fdd28a6c9549b3284fd7ae0f731
https://doi.org/10.1158/1078-0432.22463636.v1
https://doi.org/10.1158/1078-0432.22463636.v1
Autor:
Ruth J. Muschel, W. Gillies McKenna, Eric J. Bernhard, Michael R. Stratford, Jaehong Im, Naseer Qayum
Purpose: Because effective drug delivery is often limited by inadequate vasculature within the tumor, the ability to modulate the tumor microenvironment is one strategy that may achieve better drug distribution. We have previously shown that treatmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d46a10f476aa647ef157c4c584640b0c
https://doi.org/10.1158/1078-0432.c.6520508.v1
https://doi.org/10.1158/1078-0432.c.6520508.v1
Autor:
Amit Maity, Stephen M. Hahn, Cameron J. Koch, Sydney M. Evans, Eric J. Bernhard, Zibin Jiang, George J. Cerniglia, Anjali K. Gupta, Nabendu Pore
The phosphatidylinositol 3-kinase (PI3K)/Akt pathway can increase vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1α (HIF-1α) expression. We examined the effect of nelfinavir, an HIV protease inhibitor that inhibits Akt signa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62f7fcc3351051179d3ae70863ec139d
https://doi.org/10.1158/0008-5472.c.6494331
https://doi.org/10.1158/0008-5472.c.6494331
Autor:
Eric J. Bernhard, Sonal Patel, W. Gillies McKenna, Peter O'Neill, Jane Harper, Keith Cengel, Julie Diplexcito, Oliver Sampson, Eric Deutsch, Remko Prevo
Cell signaling initiated at the epidermal growth factor receptor (EGFR), RAS oncoproteins, or PI3K contributes to a common pathway that promotes tumor survival after radiation-induced DNA damage. Inhibition of signaling at the level of EGFR, RAS, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::940c1b31b18f7e5850ddb00c69b908ff
https://doi.org/10.1158/0008-5472.c.6498129.v1
https://doi.org/10.1158/0008-5472.c.6498129.v1
Autor:
Ruth J. Muschel, W. Gillies McKenna, Eric J. Bernhard, Sauveur-Michel Maira, Wolfgang Hackl, John Beech, Michael Stratford, Sabira Yameen, Sally Hill, Jae Hong Im, Emmanouil Fokas
PDf file - 824K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1226966d3aa74087a04246f489a42c54
https://doi.org/10.1158/0008-5472.22393142.v1
https://doi.org/10.1158/0008-5472.22393142.v1