Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Eric J. Aird"'
Autor:
Lukas Möller, Eric J. Aird, Markus S. Schröder, Lena Kobel, Lucas Kissling, Lilly van de Venn, Jacob E. Corn
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
CRISPR-Cas induced HDR methods tend to have a low efficiency. Here the authors report an HDR improvement strategy, Recursive Editing, that selectively retargets undesired indel outcomes to create additional opportunities for HDR; they introduce REtar
Externí odkaz:
https://doaj.org/article/83ac27ad86f2469d94b37a80c62ba679
Publikováno v:
eLife, Vol 8 (2019)
Proteolysis of transmembrane receptors is a critical cellular communication mechanism dysregulated in disease, yet decoding proteolytic regulation mechanisms of hundreds of shed receptors is hindered by difficulties controlling stimuli and unknown fa
Externí odkaz:
https://doaj.org/article/1a053fc62c1e4fb0ada97f102b933f50
Autor:
Kassidy J. Tompkins, Wendy R. Gordon, Karen Evans, Andrew T Nelson, Ke Shi, Robert L. Evans, Eric J. Aird, Hideki Aihara, Mo Houtti, Blake A Everett, L.A. Litzau, Lidia K Limón-Swanson, Leland Pornschloegl
Publikováno v:
Nucleic Acids Research
Replication initiator proteins (Reps) from the HUH-endonuclease superfamily process specific single-stranded DNA (ssDNA) sequences to initiate rolling circle/hairpin replication in viruses, such as crop ravaging geminiviruses and human disease causin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8cb44a19bc5500d9c4ab7e113ca8292
https://doi.org/10.1093/nar/gkaa1248
https://doi.org/10.1093/nar/gkaa1248
Publikováno v:
ACS Sens
Molecular tension sensors measure piconewton forces experienced by individual proteins in the context of the cellular microenvironment. Current genetically encoded tension sensors use FRET to report on extension of a deformable peptide encoded in a c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::278d795e54a0aecabd1a1d72c975a5e6
https://doi.org/10.1021/acssensors.9b00796
https://doi.org/10.1021/acssensors.9b00796
Autor:
Hideki Aihara, Andrew C. Nelson, Blake A Everett, Ke Shi, Leland Pornschloegl, Eric J. Aird, Kassidy J. Tompkins, Lidia K Limón-Swanson, Wendy R. Gordon, L.A. Litzau, Karen Evans, Robert L. Evans, Mo Houtti
Publikováno v:
The FASEB Journal. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a797ed93b74be63f24e6f4194cfc5a2
https://doi.org/10.1096/fasebj.2021.35.s1.03221
https://doi.org/10.1096/fasebj.2021.35.s1.03221
Autor:
Eric J. Aird, Wendy R. Gordon, Daniel F. Schmidt, Alina C. Zdechlik, Brian L. Ruis, Andrew T Nelson, Eric A. Hendrickson, Andrew L. Lemmex, Colette B. Rogers
Prime editing brings immense promise to correct a large number of human pathogenic mutations and enact diverse edit types without introducing widespread undesired editing events. Delivery of prime editors in vivo would enable such edits to be introdu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2113a12873719dc01dc4da2ab9b40a6a
https://doi.org/10.1101/2021.01.11.426237
https://doi.org/10.1101/2021.01.11.426237
Publikováno v:
Bioconjug Chem
Adeno-associated virus (AAV) has emerged as a viral gene delivery vector that is safe in humans, able to infect both dividing and arrested cells and drive long-term expression (>6 months). Unfortunately, the naturally evolved properties of many AAV s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1350387141095123be1ec26d4b5be1c0
https://europepmc.org/articles/PMC7676631/
https://europepmc.org/articles/PMC7676631/
Publikováno v:
Communications Biology, Vol 1, Iss 1, Pp 1-6 (2018)
The CRISPR-Cas9 system is a powerful genome-editing tool in which a guide RNA targets Cas9 to a site in the genome where the Cas9 nuclease then induces a double stranded break (DSB)1,2. The potential of CRISPR-Cas9 to deliver precise genome editing i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06de278482884dd6ba190c2f3f41cb30
http://link.springer.com/article/10.1038/s42003-018-0054-2
http://link.springer.com/article/10.1038/s42003-018-0054-2
Molecular tension sensors measure piconewton forces experienced by individual proteins in the context of the cellular microenvironment. Current genetically-encoded tension sensors use FRET to report on extension of an elastic peptide encoded in a cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1a1a3ab8b40d88c9b8ecc7f13689817