Zobrazeno 1 - 10
of 252
pro vyhledávání: '"Eric J Wagner"'
Publikováno v:
PLoS Pathogens, Vol 20, Iss 5, p e1012058 (2024)
Viral disruption of innate immune signaling is a critical determinant of productive infection. The Human Cytomegalovirus (HCMV) UL26 protein prevents anti-viral gene expression during infection, yet the mechanisms involved are unclear. We used TurboI
Externí odkaz:
https://doaj.org/article/47dc99ed77714fcba202474b4e3c3c72
Autor:
Callison E Alcott, Hari Krishna Yalamanchili, Ping Ji, Meike E van der Heijden, Alexander Saltzman, Nathan Elrod, Ai Lin, Mei Leng, Bhoomi Bhatt, Shuang Hao, Qi Wang, Afaf Saliba, Jianrong Tang, Anna Malovannaya, Eric J Wagner, Zhandong Liu, Huda Y Zoghbi
Publikováno v:
eLife, Vol 9 (2020)
We previously showed that NUDT21-spanning copy-number variations (CNVs) are associated with intellectual disability (Gennarino et al., 2015). However, the patients’ CNVs also included other genes. To determine if reduced NUDT21 function alone can c
Externí odkaz:
https://doaj.org/article/31585665f6474631989096c543a84a1e
Autor:
Natoya Peart, Eric J Wagner
Publikováno v:
BioTechniques, Vol 60, Iss 3, Pp 137-140 (2016)
The concept of mRNA 3′-end formation as a static, minimally regulated housekeeping process has undergone a paradigm shift. Many recent studies have shown that accurate and efficient 3′-end formation of mRNA is highly regulated and that dysregulat
Externí odkaz:
https://doaj.org/article/a7d99701989d4bea9e201260f9168061
Autor:
Renske Oegema, David Baillat, Rachel Schot, Leontine M van Unen, Alice Brooks, Sima Kheradmand Kia, A Jeannette M Hoogeboom, Zheng Xia, Wei Li, Matteo Cesaroni, Maarten H Lequin, Marjon van Slegtenhorst, William B Dobyns, Irenaeus F M de Coo, Debbie van den Berg, Frans W Verheijen, Andreas Kremer, Peter J van der Spek, Daphne Heijsman, Eric J Wagner, Maarten Fornerod, Grazia M S Mancini
Publikováno v:
PLoS Genetics, Vol 13, Iss 8, p e1006923 (2017)
[This corrects the article DOI: 10.1371/journal.pgen.1006809.].
Externí odkaz:
https://doaj.org/article/3a3afe24956e482688a3d4aa5b6b3abb
Autor:
Renske Oegema, David Baillat, Rachel Schot, Leontine M van Unen, Alice Brooks, Sima Kheradmand Kia, A Jeannette M Hoogeboom, Zheng Xia, Wei Li, Matteo Cesaroni, Maarten H Lequin, Marjon van Slegtenhorst, William B Dobyns, Irenaeus F M de Coo, Frans W Verheijen, Andreas Kremer, Peter J van der Spek, Daphne Heijsman, Eric J Wagner, Maarten Fornerod, Grazia M S Mancini
Publikováno v:
PLoS Genetics, Vol 13, Iss 5, p e1006809 (2017)
Integrator is an RNA polymerase II (RNAPII)-associated complex that was recently identified to have a broad role in both RNA processing and transcription regulation. Importantly, its role in human development and disease is so far largely unexplored.
Externí odkaz:
https://doaj.org/article/af63fe74d10344f78122a961db9962c3
Autor:
Ya Cui, Frederick J. Arnold, Fanglue Peng, Dan Wang, Jason Sheng Li, Sebastian Michels, Eric J. Wagner, Albert R. La Spada, Wei Li
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Alternative polyadenylation (APA) contributes to the post-transcriptional regulation of most human genes, yet the effects of APA are largely overlooked by conventional transcriptome-wide association studies (TWAS). Here, the authors conduct an APA-TW
Externí odkaz:
https://doaj.org/article/3b9acc93f1604e6d9cce16b07c9ad72d
Autor:
Bernard Fongang, Yannick N. Wadop, Yingjie Zhu, Eric J. Wagner, Andrzej Kudlicki, Maga Rowicka
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 5686-5697 (2023)
Finding the 3D structure of large, multi-subunit complexes is difficult, despite recent advances in cryo-EM technology, due to remaining challenges to expressing and purifying subunits. Computational approaches that predict protein-protein interactio
Externí odkaz:
https://doaj.org/article/c00fe776b1db45a6953ea60affc4756c
Autor:
Lauren G. Mascibroda, Mohammad Shboul, Nathan D. Elrod, Laurence Colleaux, Hanan Hamamy, Kai-Lieh Huang, Natoya Peart, Moirangthem Kiran Singh, Hane Lee, Barry Merriman, Jeanne N. Jodoin, Poojitha Sitaram, Laura A. Lee, Raja Fathalla, Baeth Al-Rawashdeh, Osama Ababneh, Mohammad El-Khateeb, Nathalie Escande-Beillard, Stanley F. Nelson, Yixuan Wu, Liang Tong, Linda J. Kenney, Sudipto Roy, William K. Russell, Jeanne Amiel, Bruno Reversade, Eric J. Wagner
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The integrator complex is required for the synthesis of protein coding and non-coding RNA and contains the protein INTS13. Here, the authors find germline mutations in INTS13 in two families with oral facial digital syndrome and show that the mutatio
Externí odkaz:
https://doaj.org/article/35883c108c1d4e72ba468a3fd1444767
Autor:
Sen Liu, Gyeong Hun Baeg, Ying Yang, Feng Guang Goh, Hongcun Bao, Eric J. Wagner, Xiaohang Yang, Yu Cai
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 112007- (2023)
Summary: Maintenance of stem cells requires the concerted actions of niche-derived signals and stem cell-intrinsic factors. Although Decapentaplegic (Dpp), a Drosophila bone morphogenetic protein (BMP) molecule, can act as a long-range morphogen, its
Externí odkaz:
https://doaj.org/article/84d609f2c4b5473995f54510f5066fac
Publikováno v:
Genes and Diseases, Vol 8, Iss 1, Pp 61-72 (2021)
Alternative polyadenylation (APA) is a molecular process that generates diversity at the 3′ end of RNA polymerase II transcripts from over 60% of human genes. APA is derived from the existence of multiple polyadenylation signals (PAS) within the sa
Externí odkaz:
https://doaj.org/article/1fdbe9364a794efa863ce2aa3af8042c