Zobrazeno 1 - 10
of 145
pro vyhledávání: '"Eric J Toone"'
Autor:
Wenle Xia, David Gooden, Leihua Liu, Sumin Zhao, Erik J Soderblom, Eric J Toone, Wayne F Beyer, Harold Walder, Neil L Spector
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88983 (2014)
Photo-activation of psoralen with UVA irradiation, referred to as PUVA, is used in the treatment of proliferative skin disorders. The anti-proliferative effects of PUVA have been largely attributed to psoralen intercalation of DNA, which upon UV trea
Externí odkaz:
https://doaj.org/article/1d28ff245e1449448ba258d2b2a9f600
Autor:
Chul-Jin Lee, Xiaofei Liang, Qinglin Wu, Javaria Najeeb, Jinshi Zhao, Ramesh Gopalaswamy, Marie Titecat, Florent Sebbane, Nadine Lemaitre, Eric J. Toone, Pei Zhou
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-7 (2016)
The conformational dynamics of a compound has a large effect on ligand/receptor binding. Here, the authors employ NMR spectroscopy to study ligand binding to the enzyme LpxC, discovering an inhibitor envelope that was not identifiable by crystallogra
Externí odkaz:
https://doaj.org/article/d7d0d77eb2224e92ad9e99b31e87c12f
Autor:
Nadine Lemaître, Xiaofei Liang, Javaria Najeeb, Chul-Jin Lee, Marie Titecat, Emmanuelle Leteurtre, Michel Simonet, Eric J. Toone, Pei Zhou, Florent Sebbane
Publikováno v:
mBio, Vol 8, Iss 4 (2017)
ABSTRACT The infectious diseases caused by multidrug-resistant bacteria pose serious threats to humankind. It has been suggested that an antibiotic targeting LpxC of the lipid A biosynthetic pathway in Gram-negative bacteria is a promising strategy f
Externí odkaz:
https://doaj.org/article/a7c043578878492fbc79153fc78569f2
Autor:
Jean-Marie Pagès, René Courcol, Pei Zhou, Marie Titecat, Nadine Lemaître, Thierry Lambert, Eric J. Toone, Audrey Charlet, Florent Sebbane, Didier Hocquet, Chul-Jin Lee, Xiaofei Liang
Publikováno v:
Journal of Antimicrobial Chemotherapy
Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2016, 71 (10), pp.2874-82. 〈10.1093/jac/dkw210〉
Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2016, 71 (10), pp.2874-82. ⟨10.1093/jac/dkw210⟩
Journal of Antimicrobial Chemotherapy, 2016, 71 (10), pp.2874-82. ⟨10.1093/jac/dkw210⟩
Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2016, 71 (10), pp.2874-82. 〈10.1093/jac/dkw210〉
Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2016, 71 (10), pp.2874-82. ⟨10.1093/jac/dkw210⟩
Journal of Antimicrobial Chemotherapy, 2016, 71 (10), pp.2874-82. ⟨10.1093/jac/dkw210⟩
International audience; Inhibitors of uridine diphosphate-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC, which catalyses the first, irreversible step in lipid A biosynthesis) are a promising new class of antibiotics against Gram-ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b1981a6aafeb94092376df4222d2d4f
https://doi.org/10.1093/jac/dkw210
https://doi.org/10.1093/jac/dkw210
Autor:
James B. Sund, Scott Wolter, Charles B. Parker, Corey P. Causey, Jeffrey T. Glass, Eric J. Toone, Brian R. Stoner
Publikováno v:
Applied Surface Science. 301:293-299
The surface of conducting diamond was functionalized with a terminal thiol group that is capable of binding and detecting nitrogen–oxygen species. The functionalization process employed multiple steps starting with doped diamond films grown by plas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f31aa611e642bc98e1619f92e19c4097
https://doi.org/10.1016/j.apsusc.2014.02.067
https://doi.org/10.1016/j.apsusc.2014.02.067
Publikováno v:
The Journal of Physical Chemistry B. 117:4755-4762
Atomic force microscopy (AFM) is used extensively for the investigation of noncovalent molecular association. Although the technique is used to derive various types of information, in almost all instances the frequency of complex formation, the magni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17d2bcf3a6fbf8a74721c6dbe7ed32b8
https://doi.org/10.1021/jp309393s
https://doi.org/10.1021/jp309393s
Publikováno v:
The Journal of organic chemistry. 81(10)
The difluoromethyl-allo-threonyl hydroxamate-based compound LPC-058 is a potent inhibitor of UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) in Gram-negative bacteria. A scalable synthesis of this compound is described. The key
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91d0c1255f5e03accc96da3d9c86b37f
https://pubmed.ncbi.nlm.nih.gov/27128325
https://pubmed.ncbi.nlm.nih.gov/27128325
Publikováno v:
ACS Applied Materials & Interfaces. 4:3932-3937
We report a versatile functionalization and pattering technique that permits multicomponent pattern-specific modification of indium tin oxide (ITO) with organic species. The method relies on a bilayered molecular system that simultaneously protects I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfb8d9028f7d2892a4cc5dd0e677c5e0
https://doi.org/10.1021/am300768f
https://doi.org/10.1021/am300768f
A general and efficient cantilever functionalization technique for AFM molecular recognition studies
Autor:
Robert L. Clark, Carleen M. Bowers, David A. Carlson, Eric J. Toone, Alexander A. Shestopalov
Publikováno v:
Biopolymers. 97:761-765
Atomic force microscopy (AFM) is a versatile technique for the investigation of noncovalent molecular associations between ligand–substrate pairs. Surface modification of silicon nitride AFM cantilevers is most commonly achieved using organic trial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbdad549bac1da513484cacb89de7dd2
https://doi.org/10.1002/bip.22061
https://doi.org/10.1002/bip.22061
Publikováno v:
Biochemistry. 51:1658-1668
The substrate specificity of enzymes is frequently narrow and constrained by multiple interactions, limiting the use of natural enzymes in biocatalytic applications. Aldolases have important synthetic applications, but the usefulness of these enzymes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db3f55255ea43f5be9eae80bac423125
https://doi.org/10.1021/bi201899b
https://doi.org/10.1021/bi201899b