Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Eric J N Helfrich"'
Autor:
Lisa Männer, Tilman Schell, Julia Spies, Carles Galià-Camps, Damian Baranski, Alexander Ben Hamadou, Charlotte Gerheim, Kornelia Neveling, Eric J. N. Helfrich, Carola Greve
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-20 (2024)
Abstract Background Sequencing and annotating genomes of non-model organisms helps to understand genome architecture, the genetic processes underlying species traits, and how these genes have evolved in closely-related taxa, among many other biologic
Externí odkaz:
https://doaj.org/article/fe8aafd55ce14a22891afb3745065e13
Autor:
Barbara R. Terlouw, Friederike Biermann, Sophie P. J. M. Vromans, Elham Zamani, Eric J. N. Helfrich, Marnix H. Medema
Publikováno v:
Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-18 (2024)
Abstract Natural products are molecules that fulfil a range of important ecological functions. Many natural products have been exploited for pharmaceutical and agricultural applications. In contrast to many other specialised metabolites, the products
Externí odkaz:
https://doaj.org/article/05b9a26e73d14f05a536e4c5488a18c0
Autor:
Eric J. N. Helfrich, Reiko Ueoka, Marc G. Chevrette, Franziska Hemmerling, Xiaowen Lu, Stefan Leopold-Messer, Hannah A. Minas, Adrien Y. Burch, Steven E. Lindow, Jörn Piel, Marnix H. Medema
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Trans-acyltransferase polyketide synthases are multimodular enzymes that synthesise diverse polyketides. Here, the authors present an algorithm for the global study of their diversity, showing exchange of conserved consecutive modules as a driver of
Externí odkaz:
https://doaj.org/article/364e7f915c97493a91491df3c9ed6014
Autor:
Taise T. H. Fukuda, Eric J. N. Helfrich, Emily Mevers, Weilan G. P. Melo, Ethan B. Van Arnam, David R. Andes, Cameron R. Currie, Monica T. Pupo, Jon Clardy
Publikováno v:
ACS Central Science, Vol 7, Iss 2, Pp 292-299 (2021)
Externí odkaz:
https://doaj.org/article/e73a9fa8d2444c0684f3173a62b65d56
Publikováno v:
mSystems, Vol 6, Iss 4 (2021)
ABSTRACT Microbes produce structurally diverse natural products to interact with their environment. Many of the biosynthetic products involved in this “metabolic small talk” have been exploited for the treatment of various diseases. As an alterna
Externí odkaz:
https://doaj.org/article/3f96e8ae0b344d8e8058418c0f2e4f09
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 2889-2906 (2019)
Terpenoids are the largest and structurally most diverse class of natural products. They possess potent and specific biological activity in multiple assays and against diseases, including cancer and malaria as notable examples. Although the number of
Externí odkaz:
https://doaj.org/article/5209b1aa51a24fddad423af7dac83c24
Autor:
Lenka Dohnalová, Patrick Lundgren, Jamie R. E. Carty, Nitsan Goldstein, Sebastian L. Wenski, Pakjira Nanudorn, Sirinthra Thiengmag, Kuei-Pin Huang, Lev Litichevskiy, Hélène C. Descamps, Karthikeyani Chellappa, Ana Glassman, Susanne Kessler, Jihee Kim, Timothy O. Cox, Oxana Dmitrieva-Posocco, Andrea C. Wong, Erik L. Allman, Soumita Ghosh, Nitika Sharma, Kasturi Sengupta, Belinda Cornes, Nitai Dean, Gary A. Churchill, Tejvir S. Khurana, Mark A. Sellmyer, Garret A. FitzGerald, Andrew D. Patterson, Joseph A. Baur, Amber L. Alhadeff, Eric J. N. Helfrich, Maayan Levy, J. Nicholas Betley, Christoph A. Thaiss
Publikováno v:
Nature. 612:739-747
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f2b1103ca28dba767e72646a911e432
https://doi.org/10.1038/s41586-022-05525-z
https://doi.org/10.1038/s41586-022-05525-z
Autor:
Jia-Xuan Yan, Qihao Wu, Eric J. N. Helfrich, Marc G. Chevrette, Doug R. Braun, Heino Heyman, Gene E. Ananiev, Scott R. Rajski, Cameron R. Currie, Jon Clardy, Tim S. Bugni
Publikováno v:
Marine Drugs, Vol 20, Iss 1, p 43 (2022)
Chemical investigations of a marine sponge-associated Bacillus revealed six new imidazolium-containing compounds, bacillimidazoles A–F (1–6). Previous reports of related imidazolium-containing natural products are rare. Initially unveiled by tims
Externí odkaz:
https://doaj.org/article/a30b31fd6e384582b8f6a2e573d9c658
Supplementary File 8.2, a zipped folder containing .png and .gif files of biosynthetic gene cluster renderings.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c63c194d409f72caf806f9632c77495
Autor:
Kai Blin, Simon Shaw, Hannah E Augustijn, Zachary L Reitz, Friederike Biermann, Mohammad Alanjary, Artem Fetter, Barbara R Terlouw, William W Metcalf, Eric J N Helfrich, Gilles P van Wezel, Marnix H Medema, Tilmann Weber
Publikováno v:
Nucleic Acids Research.
Microorganisms produce small bioactive compounds as part of their secondary or specialised metabolism. Often, such metabolites have antimicrobial, anticancer, antifungal, antiviral or other bio-activities and thus play an important role for applicati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0ad17050262dc94def2e4b98003790d
https://doi.org/10.1093/nar/gkad344
https://doi.org/10.1093/nar/gkad344