Zobrazeno 1 - 10
of 153
pro vyhledávání: '"Eric J, Sundberg"'
Autor:
Diego E. Sastre, Nazneen Sultana, Marcos V. A. S. Navarro, Maros Huliciak, Jonathan Du, Javier O. Cifuente, Maria Flowers, Xu Liu, Pete Lollar, Beatriz Trastoy, Marcelo E. Guerin, Eric J. Sundberg
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Bacteroidales (syn. Bacteroidetes) are prominent members of the human gastrointestinal ecosystem mainly due to their efficient glycan-degrading machinery, organized into gene clusters known as polysaccharide utilization loci (PULs). A single
Externí odkaz:
https://doaj.org/article/ebe073fb96474aa383a560417efd849c
Autor:
Aaron Gupta, Kevin S. Kao, Rachel Yamin, Deena A. Oren, Yehuda Goldgur, Jonathan Du, Pete Lollar, Eric J. Sundberg, Jeffrey V. Ravetch
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Immunoglobulin G (IgG) antibodies contain a complex N-glycan embedded in the hydrophobic pocket between its heavy chain protomers. This glycan contributes to the structural organization of the Fc domain and determines its specificity for Fc
Externí odkaz:
https://doaj.org/article/0c91ddacfecf4f7fb89461122325693e
Autor:
Beatriz Trastoy, Jonathan J. Du, Javier O. Cifuente, Lorena Rudolph, Mikel García-Alija, Erik H. Klontz, Daniel Deredge, Nazneen Sultana, Chau G. Huynh, Maria W. Flowers, Chao Li, Diego E. Sastre, Lai-Xi Wang, Francisco Corzana, Alvaro Mallagaray, Eric J. Sundberg, Marcelo E. Guerin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Bacterial pathogens have evolved intricate mechanisms to evade the human immune system, including the production of immunomodulatory enzymes. Here, the authors establish the mechanisms of recognition and specific deglycosylation of IgG antibodies by
Externí odkaz:
https://doaj.org/article/7aed46f3a16540f68a93f7c72eef2df7
Autor:
Marko Nedeljković, Mark A B Kreutzberger, Sandra Postel, Daniel Bonsor, Yingying Xing, Neil Jacob, William J Schuler, Edward H Egelman, Eric J Sundberg
Publikováno v:
PLoS Pathogens, Vol 19, Iss 5, p e1010979 (2023)
In its simplest form, bacterial flagellar filaments are composed of flagellin proteins with just two helical inner domains, which together comprise the filament core. Although this minimal filament is sufficient to provide motility in many flagellate
Externí odkaz:
https://doaj.org/article/d32e90e9c3444d4dabe11ba341ee2037
Autor:
Mikel García-Alija, Jonathan J. Du, Izaskun Ordóñez, Asier Diz-Vallenilla, Alicia Moraleda-Montoya, Nazneen Sultana, Chau G. Huynh, Chao Li, Thomas Connor Donahue, Lai-Xi Wang, Beatriz Trastoy, Eric J. Sundberg, Marcelo E. Guerin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
EndoE is a multi-domain glycoside hydrolase of the human pathogen Enterococcus faecalis. Here, the authors present crystal structures of EndoE and provide biochemical insights into the molecular basis of EndoE’s substrate specificity and catalytic
Externí odkaz:
https://doaj.org/article/db42ad5c6c87426d8b470e8e6d00b296
Autor:
Amit K. Gandhi, Zhen-Yu J. Sun, Walter M. Kim, Yu-Hwa Huang, Yasuyuki Kondo, Daniel A. Bonsor, Eric J. Sundberg, Gerhard Wagner, Vijay K. Kuchroo, Gregory A. Petsko, Richard S. Blumberg
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
To understand how hCEACAM1 transitions between monomeric and dimeric states that are required for its activity, Gandhi et al. investigate hCEACAM1 homodimeric, monomeric, and transition states and their behavior in solution. This study suggests the f
Externí odkaz:
https://doaj.org/article/1e98a0721d5041b7bcee1fce74ebca91
Autor:
Erik H. Klontz, Chao Li, Kyle Kihn, James K. Fields, Dorothy Beckett, Greg A. Snyder, Patrick L. Wintrode, Daniel Deredge, Lai-Xi Wang, Eric J. Sundberg
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
AlfC transfucosidase is used to modulate fucosylation of glycans decorating monoclonal antibodies. Herein, structural and biophysical characterization reveals the enzymatic mechanism of AlfC and a blueprint for the design of AlfC mutants with novel s
Externí odkaz:
https://doaj.org/article/9a30450512214f37b47bbcf6f541a3c3
Autor:
Beatriz Trastoy, Jonathan J. Du, Erik H. Klontz, Chao Li, Javier O. Cifuente, Lai-Xi Wang, Eric J. Sundberg, Marcelo E. Guerin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Human gut bacteria depolymerize glycans into their sugar components, which otherwise cannot be processed by their host. Here, the authors characterise the endo-β-N-acetylglucosaminidase EndoBT-3987 from the Gram-negative symbiont Bacteroides thetaio
Externí odkaz:
https://doaj.org/article/0967fd4440514038b204e0c6670b530c
Molecular Basis of Selective Cytokine Signaling Inhibition by Antibodies Targeting a Shared Receptor
Autor:
James K. Fields, Kyle Kihn, Gabriel S. Birkedal, Erik H. Klontz, Kjell Sjöström, Sebastian Günther, Robert Beadenkopf, Göran Forsberg, David Liberg, Greg A. Snyder, Daniel Deredge, Eric J. Sundberg
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Interleukin-1 (IL-1) family cytokines are potent mediators of inflammation, acting to coordinate local and systemic immune responses to a wide range of stimuli. Aberrant signaling by IL-1 family cytokine members, however, is linked to myriad inflamma
Externí odkaz:
https://doaj.org/article/d1aa83cba4b9429da818f4c99e7a5c77
Autor:
Asaminew H Aytenfisu, Daniel Deredge, Erik H Klontz, Jonathan Du, Eric J Sundberg, Alexander D MacKerell
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 7, p e1009103 (2021)
Antibodies bind foreign antigens with high affinity and specificity leading to their neutralization and/or clearance by the immune system. The conserved N-glycan on IgG has significant impact on antibody effector function, with the endoglycosidases o
Externí odkaz:
https://doaj.org/article/1c5a1fb3a1a0497cac4852104caef0b6