Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Eric I. Rossman"'
Autor:
Yu Fu, Hadi Taghvafard, Medhat M. Said, Eric I. Rossman, Teresa A. Collins, Stéphanie Billiald‐Desquand, Derek Leishman, Piet H. van derGraaf, J. G. Coen vanHasselt, Nelleke Snelder
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 5, Pp 640-652 (2022)
Abstract The use of systems‐based pharmacological modeling approaches to characterize mode‐of‐action and concentration‐effect relationships for drugs on specific hemodynamic variables has been demonstrated. Here, we (i) expand a previously de
Externí odkaz:
https://doaj.org/article/497d9b38105341fcb727e8737d253ee3
Autor:
Annie Delaunois, Matthew Abernathy, Warren D. Anderson, Kylie A. Beattie, Khuram W. Chaudhary, Julie Coulot, Vitalina Gryshkova, Simon Hebeisen, Mark Holbrook, James Kramer, Yuri Kuryshev, Derek Leishman, Isabel Lushbough, Elisa Passini, Will S. Redfern, Blanca Rodriguez, Eric I. Rossman, Cristian Trovato, Caiyun Wu, Jean‐Pierre Valentin
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 3, Pp 1133-1146 (2021)
Abstract We applied a set of in silico and in vitro assays, compliant with the Comprehensive In Vitro Proarrhythmia Assay (CiPA) paradigm, to assess the risk of chloroquine (CLQ) or hydroxychloroquine (OH‐CLQ)‐mediated QT prolongation and Torsade
Externí odkaz:
https://doaj.org/article/d703d6568c29415c8e2d93ccf47af5d0
Autor:
Emmanuel Boulay, Loïs S. Miraucourt, Michael K. Pugsley, Matthew M. Abernathy, Ray Chui, Jill Dalton, Marjorie Demers, Noel Dybdal, Elissa Gazaille, Andrea Greiter-Wilke, Peter Hoffmann, Hai Huang, Carrie LaDuke, Kevin Norton, Jennifer B. Pierson, Isabelle Reeves, Brian Roche, Eric I. Rossman, Albert E. Schultze, Hai-Ming Tang, Todd Wisialowski, Simon Authier
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 121:107266
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::406a64798c781d5c1aa3597ac181212a
https://doi.org/10.1016/j.vascn.2023.107266
https://doi.org/10.1016/j.vascn.2023.107266
Autor:
Hugo M. Vargas, Eric I. Rossman, Todd A. Wisialowski, Jill Nichols, Michael K. Pugsley, Brian Roche, Gary A. Gintant, Andrea Greiter-Wilke, Robert B. Kleiman, Jean-Pierre Valentin, Derek J. Leishman
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 121:107265
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be76a6ce3a2e0c4c2deec09e77581719
https://doi.org/10.1016/j.vascn.2023.107265
https://doi.org/10.1016/j.vascn.2023.107265
Autor:
Eric I. Rossman, Todd A. Wisialowski, Hugo M. Vargas, Jean-Pierre Valentin, Michael G. Rolf, Brian M. Roche, Steve Riley, Michael K. Pugsley, Jill Nichols, Dingzhou Li, Derek J. Leishman, Robert B. Kleiman, Andrea Greiter-Wilke, Gary A. Gintant, Michael J. Engwall, Annie Delaunois, Simon Authier
Publikováno v:
Journal of Pharmacological and Toxicological Methods. :107270
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9bce4cdaca3426f8bebb1500bde7339b
https://doi.org/10.1016/j.vascn.2023.107270
https://doi.org/10.1016/j.vascn.2023.107270
Autor:
Nurul A N Mohd Yusof, Christine L. Mummery, Leon G.J. Tertoolen, Jessica Nebel, Peter Clements, Eric I. Rossman, Umber Saleem, Ana Krotenberg Garcia, Kate Harris, Maria L. H. Vlaming, Karen McGlynn, Godfrey L. Smith, Xiaoping Xu, Puspita A Katili, Tessa de Korte, Francis L. Burton, Berend J. van Meer, Ingra Mannhardt, Arne Hansen, Chris Denning, Anthony Bahinski, Thomas Eschenhagen
Publikováno v:
Toxicological Sciences
Toxicological Sciences, 176(1), 103-123. OXFORD UNIV PRESS
Toxicological Sciences, 176(1), 103-123. Oxford University Press
Toxicological Sciences, 176(1), 103-123. OXFORD UNIV PRESS
Toxicological Sciences, 176(1), 103-123. Oxford University Press
Animal models are 78% accurate in determining whether drugs will alter contractility of the human heart. To evaluate the suitability of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) for predictive safety pharmacology, we quan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2e9cc5a4d7797253c1110ea6d84aca8
http://europepmc.org/articles/PMC7357169
http://europepmc.org/articles/PMC7357169
Autor:
Gregory S. Friedrichs, David G. Strauss, Ariane Menard, Jill Steidl-Nichols, Jean-Michel Guillon, Nicolas Gendron-Parra, Simon Authier, Jean-Pierre Valentin, Ray W. Chui, Jennifer B. Pierson, Michael K. Pugsley, Eric I. Rossman, Todd Wisialowski, Matthew M. Abernathy, Emmanuel Boulay, John Koerner, Andrea Greiter-Wilke, Eric Troncy
Publikováno v:
International Journal of Toxicology. 38:23-32
Introduction: Based on the ICH S7B and E14 guidance documents, QT interval (QTc) is used as the primary in vivo biomarker to assess the risk of drug-induced torsades de pointes (TdP). Clinical and nonclinical data suggest that drugs that prolong the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef70e5850a2a9fe87809255931a38c98
https://doi.org/10.1177/1091581818813601
https://doi.org/10.1177/1091581818813601
Autor:
Isabel Lushbough, Jean-Pierre Valentin, Vitalina Gryshkova, Simon Hebeisen, Cristian Trovato, Will S. Redfern, Khuram W. Chaudhary, Caiyun Wu, Eric I. Rossman, Kylie A. Beattie, Julie Coulot, Elisa Passini, Yuri A. Kuryshev, Warren D. Anderson, Blanca Rodriguez, Annie Delaunois, Derek J. Leishman, Matthew M. Abernathy, James Kramer, Mark Holbrook
Publikováno v:
Clinical and Translational Science
Clinical and Translational Science, Vol 14, Iss 3, Pp 1133-1146 (2021)
Clinical and Translational Science, Vol 14, Iss 3, Pp 1133-1146 (2021)
We applied a set of in silico and in vitro assays, compliant with the CiPA (Comprehensive In Vitro Proarrhythmia Assay) paradigm, to assess the risk of chloroquine or hydroxychloroquine‐mediated QT prolongation and Torsades de Pointes (TdP), alone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::581ff6229742ba87f71f81a342b9f06c
http://europepmc.org/articles/PMC8014548
http://europepmc.org/articles/PMC8014548
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 111:107018
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1144a241c573fdad34403c285e8499c
https://doi.org/10.1016/j.vascn.2021.107018
https://doi.org/10.1016/j.vascn.2021.107018
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 111:107006
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a7d1d853c890974663adc140ba2320e
https://doi.org/10.1016/j.vascn.2021.107006
https://doi.org/10.1016/j.vascn.2021.107006