Mammalian Hbs1L deficiency causes congenital anomalies and developmental delay associated with Pelota depletion and 80S monosome accumulation.

Autor: Amy E O'Connell, Maxim V Gerashchenko, Marie-Francoise O'Donohue, Samantha M Rosen, Eric Huntzinger, Diane Gleeson, Antonella Galli, Edward Ryder, Siqi Cao, Quinn Murphy, Shideh Kazerounian, Sarah U Morton, Klaus Schmitz-Abe, Vadim N Gladyshev, Pierre-Emmanuel Gleizes, Bertrand Séraphin, Pankaj B Agrawal

Publikováno v: PLoS Genetics, Vol 15, Iss 2, p e1007917 (2019)

Hbs1 has been established as a central component of the cell's translational quality control pathways in both yeast and prokaryotic models; however, the functional characteristics of its human ortholog (Hbs1L) have not been well-defined. We recently

Externí odkaz: https://doaj.org/article/838e030b6548429aa6d8c95b74d43a7e

Mammalian Hbs1L deficiency causes congenital anomalies and developmental delay associated with Pelota depletion and 80S monosome accumulation

Autor: Samantha M. Rosen, Shideh Kazerounian, Klaus Schmitz-Abe, Marie-Françoise O'Donohue, Pierre-Emmanuel Gleizes, Pankaj B. Agrawal, Eric Huntzinger, Edward Ryder, Maxim V. Gerashchenko, Vadim N. Gladyshev, Diane Gleeson, Quinn Murphy, Sarah U. Morton, Bertrand Séraphin, Antonella Galli, Amy E. O’Connell, Siqi Cao

Publikováno v: PLoS Genetics
PLoS Genetics, Public Library of Science, 2019, 15 (2), pp.e1007917. ⟨10.1371/journal.pgen.1007917⟩
PLoS Genetics, Vol 15, Iss 2, p e1007917 (2019)

Hbs1 has been established as a central component of the cell’s translational quality control pathways in both yeast and prokaryotic models; however, the functional characteristics of its human ortholog (Hbs1L) have not been well-defined. We recentl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d61982dfd7029af3e1b0f98d91888846
https://hal.archives-ouvertes.fr/hal-02327840/file/islandora_84261.pdf

Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing

Autor: Eric Huntzinger, Tobias Doerks, Michael Boutros, Schu Fee Yang, Jan Rehwinkel, Mona Stricker, Peer Bork, Ana Eulalio, Silke Dorner, Elisa Izaurralde

microRNAs (miRNAs) silence gene expression by suppressing protein production and/or by promoting mRNA decay. To elucidate how silencing is accomplished, we screened an RNA interference library for suppressors of miRNA-mediated regulation in Drosophil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7934d27629a33035c2f9a9c878ba233
https://ora.ox.ac.uk/objects/uuid:6a3e9f3a-df7a-4293-abfd-e944d5f948b0

Gene silencing by microRNAs: contributions of translational repression and mRNA decay

Autor: Elisa Izaurralde, Eric Huntzinger

Publikováno v: Nature Reviews Genetics. 12:99-110

Despite their widespread roles as regulators of gene expression, important questions remain about target regulation by microRNAs. Animal microRNAs were originally thought to repress target translation, with little or no influence on mRNA abundance, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::532d9a60b32ca1777e74675e28658abe
https://doi.org/10.1038/nrg2936

Role of GW182 proteins and PABPC1 in the miRNA pathway: a sense of déjà vu

Autor: Felix Tritschler, Elisa Izaurralde, Eric Huntzinger

Publikováno v: Nature Reviews Molecular Cell Biology. 11:379-384

GW182 proteins have emerged as key components of microRNA (miRNA) silencing complexes in animals. Although the precise molecular function of GW182 proteins is not fully understood, new findings indicate that they act as poly(A)-binding protein (PABP)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::669bfbac34ab90918d5e64a215770636
https://doi.org/10.1038/nrm2885