Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Eric Hortense"'
Autor:
Alan D. Borthwick, Marie Charbaut, Robert J. Young, Máire A. Convery, Ivan Leo Pinto, Andrew M. Mason, Weston Helen Elisabeth, Matthew Campbell, David W. Brown, Anthony J. Pateman, Henry Anderson Kelly, Derek Pollard, Shah Gita Punjabhai, John R. Toomey, N. Paul King, Stefan Senger, Eric Hortense, Ping Zhou, Hawa Diallo, Nigel S. Watson, Wendy R. Irving, Angela Patikis, Cynthia L. Burns-Kurtis, Savvas Kleanthous, Chuen Chan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:28-33
Structure and property based drug design was exploited in the synthesis of sulfonamidopyrrolidin-2-one-based factor Xa (fXa) inhibitors, incorporating basic biaryl P4 groups, producing highly potent inhibitors with significant anticoagulant activitie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03145f782eb525e093f927857c7919cd
https://doi.org/10.1016/j.bmcl.2007.11.019
https://doi.org/10.1016/j.bmcl.2007.11.019
Autor:
Máire A. Convery, Stephanie Irvine, Graham Foster, Mike Blows, Robert J. Young, Steve Jackson, Stefan Senger, Angela Patikis, Eric Hortense, Cynthia L. Burns-Kurtis, John R. Toomey, Carl Adams, Savvas Kleanthous, Gary J. Stelman, David W. Brown, John D. Harling, Nigel S. Watson, Ping Zhou, Robert I. West, Wendy R. Irving, Anne M. Exall, Theresa J. Roethka, David E. Davies, Anthony J. Pateman, Chuen Chan, Laiq Chaudry, Caroline M. Whittaker
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(6)
The rational design, syntheses and evaluation of potent sulfonamidopyrrolidin-2-one-based factor Xa inhibitors incorporating aminoindane and phenylpyrrolidine P4 motifs are described. These series delivered highly potent anticoagulant compounds with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a38372eac43a80c90c25beb16d8fc57
https://pubmed.ncbi.nlm.nih.gov/21349710
https://pubmed.ncbi.nlm.nih.gov/21349710