Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Eric Hidari"'
Autor:
Zengjie Xia, Emily E. Prescott, Agnieszka Urbanek, Hollie E. Wareing, Marianne C. King, Anna Olerinyova, Helen Dakin, Tom Leah, Katy A. Barnes, Martyna M. Matuszyk, Eleni Dimou, Eric Hidari, Yu P. Zhang, Jeff Y. L. Lam, John S. H. Danial, Michael R. Strickland, Hong Jiang, Peter Thornton, Damian C. Crowther, Sohvi Ohtonen, Mireia Gómez-Budia, Simon M. Bell, Laura Ferraiuolo, Heather Mortiboys, Adrian Higginbottom, Stephen B. Wharton, David M. Holtzman, Tarja Malm, Rohan T. Ranasinghe, David Klenerman, Suman De
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Which isoforms of apolipoprotein E (apoE) we inherit determine our risk of developing late-onset Alzheimer’s Disease (AD), but the mechanism underlying this link is poorly understood. In particular, the relevance of direct interactions bet
Externí odkaz:
https://doaj.org/article/65a320a335c64d1798e94a4de6e507f4
Autor:
Tanrada Pansuwan, Annelies Quaegebeur, Sanne S. Kaalund, Eric Hidari, Mayen Briggs, James B. Rowe, Timothy Rittman
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-21 (2023)
Abstract The development of novel treatments for Progressive Supranuclear Palsy (PSP) is hindered by a knowledge gap of the impact of neurodegenerative neuropathology on brain structure and function. The current standard practice for measuring postmo
Externí odkaz:
https://doaj.org/article/874c239c0f8d4bf0ab70c2dbddfe21fa
Autor:
Eleni Dimou, Taxiarchis Katsinelos, Georg Meisl, Benjamin J. Tuck, Sophie Keeling, Annabel E. Smith, Eric Hidari, Jeff Y.L. Lam, Melanie Burke, Sofia Lövestam, Rohan T. Ranasinghe, William A. McEwan, David Klenerman
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112725- (2023)
Summary: Tau is a soluble protein interacting with tubulin to stabilize microtubules. However, under pathological conditions, it becomes hyperphosphorylated and aggregates, a process that can be induced by treating cells with exogenously added tau fi
Externí odkaz:
https://doaj.org/article/0d8cb954a0e54cd6965759734192cc83
Autor:
Jonathan X. Meng, Yu Zhang, Dominik Saman, Arshad M. Haider, Suman De, Jason C. Sang, Karen Brown, Kun Jiang, Jane Humphrey, Linda Julian, Eric Hidari, Steven F. Lee, Gabriel Balmus, R. Andres Floto, Clare E. Bryant, Justin L. P. Benesch, Yu Ye, David Klenerman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
In this work, the authors report that hyperphosphorylated recombinant tau spontaneously assembles into small, amorphous aggregates, which disrupt membranes and induce Toll-like receptor 4-dependent responses in human macrophages.
Externí odkaz:
https://doaj.org/article/bc2803e2004a427bb2eed72cdc9d158e
Autor:
Jason C. Sang, Eric Hidari, Georg Meisl, Rohan T. Ranasinghe, Maria Grazia Spillantini, David Klenerman
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Jason Sang et al. use super-resolution microscopy to monitor α-synuclein aggregation and uptake in SH-SY5Y neuroblastoma cells. Their results suggest that cells secrete nanoscopic aggregates in response to disruption of protein homeostasis by these
Externí odkaz:
https://doaj.org/article/fb50d58e8455415e95e500de6612683f
Autor:
Zengjie Xia, Emily Prescott, Hollie Wareing, Martyna Matuszyk, Helen Dakin, Eleni Dimou, Eric Hidari, Yu Zhang, Jeff Lam, John Danial, Tom Leah, Katy Barnes, Hong Jiang, Michael Strickland, Peter Thornton, Damian Crowther, David Holtzman, Simon Bell, Adrian Higginbottom, Laura Ferraiuolo, Heather Mortiboys, Stephen Wharton, Rohan Ranasinghe, David Klenerman, Suman De
Which isoforms of apolipoprotein E (apoE) we inherit determine our risk of developing late-onset Alzheimer’s Disease (AD), but the mechanism underlying this link is poorly understood. In particular, the relevance of direct interactions between apoE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c944e656d7418a8ab9133ba5e06d457
https://doi.org/10.21203/rs.3.rs-2208663/v1
https://doi.org/10.21203/rs.3.rs-2208663/v1
Autor:
Jeffrey W. Dalley, Oleg Anichtchik, David Klenerman, Bernard L. Schneider, Martyna Podgajna, Laura Calo, Eric Hidari, Emma Carlson, Maria Grazia Spillantini, Michal Wegrzynowicz
Publikováno v:
Brain
α-Synuclein aggregation at the synapse is an early event in Parkinson’s disease and is associated with impaired striatal synaptic function and dopaminergic neuronal death. The cysteine string protein (CSPα) and α-synuclein have partially overlap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef37fbc37bae8ad9c7634522638b95b9
https://doi.org/10.1093/brain/awab076
https://doi.org/10.1093/brain/awab076
Autor:
Rohan T. Ranasinghe, David Klenerman, Georg Meisl, Jason C. Sang, Eric Hidari, Maria Grazia Spillantini
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Communications Biology
Communications Biology
Funder: Royal Society; doi: https://doi.org/10.13039/501100000288
Funder: UK Dementia Research Institute
Aggregation of α-synuclein (α-syn) is closely linked to Parkinson’s disease (PD) and the related synucleinopathies. Aggregates spre
Funder: UK Dementia Research Institute
Aggregation of α-synuclein (α-syn) is closely linked to Parkinson’s disease (PD) and the related synucleinopathies. Aggregates spre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19fdb186ca7ba6fdc4ba6cd7dbe6497e
Autor:
Clare E. Bryant, Yu Ye, Yu Zhang, Linda Julian, Dominik Saman, Justin L. P. Benesch, Eric Hidari, Steven F. Lee, R. Andres Floto, Jane Humphrey, Jason C. Sang, Suman De, Jonathan Meng, Kun Jiang, David Klenerman
Soluble aggregates of the microtubule-associated protein tau have been challenging to assemble and characterize, despite their important role in the development of tauopathies. We found that sequential hyperphosphorylation by PKA in conjugation with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eacddb01b1663bf78582d698c4e38b0c
https://doi.org/10.21203/rs.3.rs-374549/v1
https://doi.org/10.21203/rs.3.rs-374549/v1
Autor:
Daniel R. Whiten, Santiago Enrique Sanchez, David Klenerman, Eric Hidari, Georg Meisl, Francesco Simone Ruggeri
Publikováno v:
ChemBioChem
ChemBioChem, 22(19), 2867-2871
ChemBioChem 22 (2021) 19
Chembiochem
ChemBioChem, 22(19), 2867-2871
ChemBioChem 22 (2021) 19
Chembiochem
The aggregation of α‐synuclein into small soluble aggregates and then fibrils is important in the development and spreading of aggregates through the brain in Parkinson's disease. Fibrillar aggregates can grow by monomer addition and then break in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79dc3b5affa9bdecb48eb8cdb3ae334e