Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Eric Hartkoorn"'
Autor:
Ben Berkhout, Angelique A. C. Lemckert, Jos M. Grimbergen, Ronald Vogels, Paul H.A. Quax, Shirley Smits, Eric Hartkoorn, Dan H. Barouch, Lennart Holterman, Menzo J. E. Havenga, Jaap Goudsmit
Publikováno v:
Journal of general virology, 87(10), 2891-2899. Society for General Microbiology
Recombinant adenoviral vectors based on type 5 (rAd5) show great promise as a vaccine carrier. However, neutralizing activity against Ad5 is prevalent and high-titred among human populations, and significantly dampens Ad5-based vaccine modalities. Th
Autor:
Angelique A. C. Lemckert, Jos M. Grimbergen, Irma Damen, Marco G. Cecchini, Germaine Penders, Niels Helmus, David Zuijdgeest, Michelle van Meerendonk, Wouter Koudstaal, Olga J.A.E Ophorst, Abraham Bout, Richard van Rijnsoever, Jaap Goudsmit, Antoinette Wetterwald, Björn F. Koel, Eric Hartkoorn, Marie-Pierre de Béthune, Ronald Vogels, Stefan Kostense, Laura Panitti, Mieke Caroline Sprangers, Menzo J. E. Havenga, Paul H.A. Quax
Publikováno v:
Journal of virology, 77(15), 8263-8271. American Society for Microbiology
Journal of Virology, 15, 77, 8263-8271
Journal of Virology, 15, 77, 8263-8271
Replication-deficient human adenovirus type 5 (Ad5) can be produced to high titers in complementing cell lines, such as PER.C6, and is widely used as a vaccine and gene therapy vector. However, preexisting immunity against Ad5 hampers consistency of