Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Eric Hack"'
Autor:
Natalie I. Mazur, Yvette N. Löwensteyn, Jonne Terstappen, Jeanette Leusen, Fred Schobben, Daniela Cianci, Peter M. van de Ven, Stefan Nierkens, Louis J. Bont, Elisabeth E. Nibbelke, Brigitte Buiteman, Neele Rave, Marlies Vermaas-van Putten, Elly A. Smit-Kleinlugtenbeld, Jacqueline P. de Lege-Korstanje, Marieke G. Peetsold, Anthon Hulsmann, Sandy van Gool, Yvonne Snepvangers, Max Colombijn, Negassi Menelik, Stephanie de Crom, Ben Semmekrot, Wouter J. de Waal, Eline Okhuijsen, Gavin W. ten Tusscher, Ronald A. de Moor, Mijke A. Breukels, Claire Lutterman, Gerdien A. Tramper-Stranders, Johanna H. Oudshoorn, Astrid Ritman, Jeannette S. von Lindern, Gerdina H. Dubbink-Verheij, Maartje M. van den Berg, Marlon E.F. Wilsterman, Edwin Rietveld, Willemijn van Heel, Anne M. de Grauw, Femke Croes, Rienus A. Doedens, Lonneke van Onzenoort-Bokken, Clemens B. Meijssen, Machteld van Scherpenzeel-de Vries, Petra Hoekstra, Linda G.M. van Rooij, Willem-Pieter de Boode, Maaike C. van Rossem, Petra Sipkema, Monique A.M. Jacobs, Marianne A. van Houten, Indrani Kok-Wijesinha, Arine M. Vlieger, Walter Balemans, Frans B. Plötz, Naomi Reijmerink, Stefan M. van Dorth, Willem Heikens, Anke G. Kuijpers, Christel Geesing, Bas J.P. Delsing, Mieke Aldenhoven, Karoly Illy, Eric Hack, Floris Groenendaal, Nicole Derksen, Katrien Oude Rengerink, Jan Meeldijk, Lysette Ebskamp-van Raaij, Jolanda D.F. de Groot-Mijnes, Rob Schuurman
Publikováno v:
EClinicalMedicine, Vol 66, Iss , Pp 102324- (2023)
Summary: Background: Mucosal administration of monoclonal antibodies (mAbs) against respiratory pathogens is a promising alternative for systemic administration because lower doses are required for protection. Clinical development of mucosal mAbs is
Externí odkaz:
https://doaj.org/article/3b10db5a31b4478c974b1456f290efa3
Autor:
Corie A. Ellison, Nicola J. Hewitt, A.M. Api, Sanket Gadhia, Mustafa Varcin, Andreas Schepky, Alina Efremenko, Richard A. Becker, C. Eric Hack
Publikováno v:
Frontiers in Toxicology. 2
The Threshold of Toxicological Concern (TTC) is a risk assessment tool for evaluating low-level exposure to chemicals with limited toxicological data. A next step in the ongoing development of TTC is to extend this concept further so that it can be a
Autor:
Gladys Ouedraogo, Camilla Alexander-White, Dagmar Bury, Harvey J. Clewell, Mark Cronin, Tom Cull, Matthew Dent, Bertrand Desprez, Ann Detroyer, Corie Ellison, Stefania Giammanco, Eric Hack, Nicola J. Hewitt, Gerry Kenna, Martina Klaric, Reinhard Kreiling, Cathy Lester, Catherine Mahony, Enrico Mombelli, Jorge Naciff, John O'Brien, Andreas Schepky, Sarah Tozer, Bart van der Burg, Barbara van Vugt-Lussenburg, Sharon Stuard, null Cosmetics Europe
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 132
Parabens are esters of para-hydroxybenzoic acid that have been used as preservatives in many types of products for decades including agrochemicals, pharmaceuticals, food and cosmetics. This illustrative case study with propylparaben (PP) demonstrates
Autor:
Bertrand Desprez, Alicia Paini, Nicola J. Hewitt, Catherine Mahony, Mark T. D. Cronin, Cathy Lester, Eric Hack, Gerry Kenna, Andreas Schepky, James W. Firman, Alina Efremenko, Harvey J. Clewell, Martina Klaric, Camilla Alexander-White, Cosmetics Europe, Dagmar Bury, Ann Detroyer, Gladys Ouedraogo
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 123
This case study on the model substance caffeine demonstrates the viability of a 10-step read-across (RAX) framework in practice. New approach methodologies (NAM), including RAX and physiologically-based kinetic (PBK) modelling were used to assess the
Publikováno v:
In Regulatory Toxicology and Pharmacology 2006 46(1):63-83
Publikováno v:
Risk Analysis: An International Journal. Aug2007, Vol. 27 Issue 4, p947-959. 13p. 1 Diagram, 5 Charts, 2 Graphs.
Autor:
C. Eric Hack, Jeffery M. Gearhart
Publikováno v:
Journal of Aerosol Science. 99:144-156
A rabbit lung morphology model was developed based on data available in the published literature. The airways of the lung were described with a typical path model. The lung airways are grouped by airway generation, which is the number of airway bifur
Autor:
Jeanne Y. Domoradzki, C. Eric Hack, Paul M. Hinderliter, Kota Hirasawa, Alicia Paini, Annie Lumen, Yu-Mei Tan, Jeremy A. Leonard, John F. Wambaugh, Fagen Zhang, Jeffrey W. Fisher, Michelle R. Embry, Amechi Chukwudebe, Melissa Chan, Patricia Ruiz, Hua Qian
Publikováno v:
Regulatory toxicology and pharmacology : RTP
Physiologically-based pharmacokinetic (PBPK) modeling analysis does not stand on its own for regulatory purposes but is a robust tool to support drug/chemical safety assessment. While the development of PBPK models have grown steadily since their eme
Autor:
Salil N. Pendse, Marjory Moreau, Patrick D. McMullen, Harvey J. Clewell, Michael W. Dzierlenga, Chantel I. Nicolas, C. Eric Hack, Pankajini Mallick, Miyoung Yoon, Alina Efremenko
Publikováno v:
Computational Toxicology. 13:100115
An outstanding challenge in the acceptance of alternatives to animal testing is the systematic incorporation of computational models into decision making pipelines. Fifteen years ago, the US EPA Office of Research and Development's framework for comp
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 103
The United States Environmental Protection Agency's (USEPA) 2017 report, “Draft Report: Proposed Approaches to Inform the Derivation of a Maximum Contaminant Level Goal for Perchlorate in Drinking Water”, proposes novel approaches for deriving a