Výsledky vyhledávání - "Eric H Holmes"

Akademický článek

Permeability enhancers dramatically increase zanamivir absolute bioavailability in rats: implications for an orally bioavailable influenza treatment.

Autor: Eric H Holmes, Harikrishna Devalapally, Libin Li, Michael L Perdue, Gary K Ostrander

Publikováno v: PLoS ONE, Vol 8, Iss 4, p e61853 (2013)

We have demonstrated that simple formulations composed of the parent drug in combination with generally regarded as safe (GRAS) permeability enhancers are capable of dramatically increasing the absolute bioavailability of zanamivir. This has the adva

Externí odkaz: https://doaj.org/article/162a9cbf8827439189a20d6fded9b791

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Castanospermine reduces Zika virus infection-associated seizure by inhibiting both the viral load and inflammation in mouse models

Autor: Yichen Cheng, Hengli Tang, Anil Mathew Tharappel, Eric H. Holmes, Gary K. Ostrander

Publikováno v: Antiviral Research

Zika virus (ZIKV) outbreaks have been reported worldwide, including a recent occurrence in Brazil where it spread rapidly, and an association with increased cases of microcephaly was observed in addition to neurological issues such as GBS that were r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87db719694f3ba5cda6b4290a53fa3c5
http://europepmc.org/articles/PMC7492813

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Site-specific Fucosylation of Sialylated Polylactosamines by α1,3/4-Fucosyltransferases-V and -VI Is Defined by Amino Acids Near the N Terminus of the Catalytic Domain

Autor: Franziska Jost, Bruce A. Macher, Ronald Knegtel, Susan R. Watson, Eric H. Holmes, Susan Shetterly

Publikováno v: Journal of Biological Chemistry. 282:24882-24892

Fucose transfer from GDP-fucose to GlcNAc residues of the sialylated polylactosamine acceptor NeuAcalpha2-3Galbeta1-4Glc-NAcbeta1-3Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glcbeta1-ceramide leads to two isomeric monofucosyl antigens, VIM2 and sialyl-Le(x). H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d20d4b5000f563d3b05bb1d57fd12026
https://doi.org/10.1074/jbc.m702395200

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A highly conserved His-His motif present in 1->3/4fucosyltransferases is required for optimal activity and functions in acceptor binding

Autor: Mark R. Stroud, Anne L. Sherwood, Eric H. Holmes, William C. Davis, David A. Upchurch

Publikováno v: Glycobiology. 12:599-606

Alpha1-->3/4fucosyltransferases (FucTs) from several species contain a highly conserved His-His motif adjacent to an enzyme region correlating with the ability to catalyze fucose transfer to type 1 chain acceptors. Site-directed mutagenesis has been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e88af843a23a938b77b94cb80bed560d
https://doi.org/10.1093/glycob/cwf075

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Oxidative Damage to the c-fos Gene and Reduction of Its Transcription After Focal Cerebral Ischemia

Autor: Jiankun Cui, Philip K. Liu, Eric H. Holmes

Publikováno v: Journal of Neurochemistry. 73:1164-1174

An elevated sensitivity to oxidative stress in certain populations of brain cells may be a key mechanism underlying several neurological disorders (Liu et al., 1989; Jenner et al., 1992; Neve, 1996; Parshad et al., 1996; Kisby et al., 1997). Numerous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d94db1cf77f6bf09354a818967fd85a
https://doi.org/10.1046/j.1471-4159.1999.0731164.x

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Fucosyltransferases: structure/function studies

Autor: Bruce A. Macher, Theodora de Vries, Eric H. Holmes, Ronald Knegtel

Publikováno v: Glycobiology. 11:119R-128R

Alpha3-fucosyltransferases (alpha3-FucTs) catalyze the final step in the synthesis of a range of important glycoconjugates that function in cell adhesion and lymphocyte recirculation. Six members of this family of enzymes have been cloned from the hu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a62a23358e9b274923dd6ca237293a6
https://doi.org/10.1093/glycob/11.10.119r

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PSMA specific antibodies and their diagnostic and therapeutic use

Autor: Eric H. Holmes

Publikováno v: Expert Opinion on Investigational Drugs. 10:511-519

Prostate-specific membrane antigen (PSMA) is a membrane-bound glycoprotein highly restricted to prostatic epithelial cells. PSMA expression is increased in association with prostatic cancer, particularly in hormone refractory disease. Given its membr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d879abb381daaa0abed58985e623c23d
https://doi.org/10.1517/13543784.10.3.511

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Human α1,3/4 Fucosyltransferases

Autor: Abderrahman Maftah, Raymond Julien, Scott Thomas, Ten-Yang Yen, Bruce A. Macher, Eric H. Holmes, François Gallet, Rajesh K. Joshi, Anton T. Nguyen, Tracy Long

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, 2000, 275 (32), pp.24237-24245. ⟨10.1074/jbc.m000888200⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2000, 275 (32), pp.24237-24245. ⟨10.1074/jbc.m000888200⟩

Human α1,3 fucosyltransferases (FucTs) contain four highly conserved cysteine (Cys) residues, in addition to a free Cys residue that lies near the binding site for GDP-fucose (Holmes, E. H., Xu, Z., Sherwood, A. L., and Macher, B. A. (1995)J. Biol.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c626fd810ce7d7f65d71833335b3174b
https://doi.org/10.1074/jbc.m000888200

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