Zobrazeno 1 - 10
of 184
pro vyhledávání: '"Eric Gouaux"'
Autor:
Yeoan Youn, Gloria W. Lau, Yongjae Lee, Barun Kumar Maity, Eric Gouaux, Hee Jung Chung, Paul R. Selvin
Publikováno v:
Cell Reports: Methods, Vol 3, Iss 2, Pp 100408- (2023)
Summary: DNA-point accumulation for imaging at nanoscale topography (DNA-PAINT) can image fixed biological specimens with nanometer resolution and absolute stoichiometry. In living systems, however, the usage of DNA-PAINT has been limited due to high
Externí odkaz:
https://doaj.org/article/8a69ca283c724d42b272a48436ac0566
Autor:
Prashant Rao, Eric Gouaux
Publikováno v:
PLoS ONE, Vol 18, Iss 3, p e0275351 (2023)
The majority of fast, excitatory synaptic transmission in the central nervous system (CNS) is mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs), which are glutamate-activated ion channels integral to synaptic plasti
Externí odkaz:
https://doaj.org/article/36a6bc2c27264ee99254c7ef4203e434
Autor:
Per Plenge, Dongxue Yang, Kristine Salomon, Louise Laursen, Iris E. Kalenderoglou, Amy H. Newman, Eric Gouaux, Jonathan A. Coleman, Claus J. Loland
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Vilazodone (VLZ) is a drug for the treatment of major depressive disorders that targets the serotonin transporter (SERT). Here, the authors combine pharmacology measurements and cryo-EM structural analysis to characterize VLZ binding to SERT and obse
Externí odkaz:
https://doaj.org/article/7e4dd1b8938f4697aed6a531fb670e57
Publikováno v:
eLife, Vol 11 (2022)
To clarify the determinants of agonist efficacy in pentameric ligand-gated ion channels, we examined a new compound, aminomethanesulfonic acid (AMS), a molecule intermediate in structure between glycine and taurine. Despite wide availability, to date
Externí odkaz:
https://doaj.org/article/118ef9a0f05d4c0c9ffa28fc2a7085f6
Publikováno v:
PLoS ONE, Vol 17, Iss 8, p e0271799 (2022)
Ionotropic glutamate receptors (iGluRs) at postsynaptic terminals mediate the majority of fast excitatory neurotransmission in response to release of glutamate from the presynaptic terminal. Obtaining structural information on the molecular organizat
Externí odkaz:
https://doaj.org/article/7496f9954a614c04ac1dd5db04401a92
Publikováno v:
eLife, Vol 10 (2021)
Mechanosensory transduction (MT), the conversion of mechanical stimuli into electrical signals, underpins hearing and balance and is carried out within hair cells in the inner ear. Hair cells harbor actin-filled stereocilia, arranged in rows of desce
Externí odkaz:
https://doaj.org/article/10c42af590ba43cb8bfaac704286f5f9
Autor:
Jonathan A Coleman, Vikas Navratna, Daniele Antermite, Dongxue Yang, James A Bull, Eric Gouaux
Publikováno v:
eLife, Vol 9 (2020)
Antidepressants target the serotonin transporter (SERT) by inhibiting serotonin reuptake. Structural and biochemical studies aiming to understand binding of small-molecules to conformationally dynamic transporters like SERT often require thermostabil
Externí odkaz:
https://doaj.org/article/ed86fc1036154b128e88ad748eb289b4
Autor:
Nate Yoder, Eric Gouaux
Publikováno v:
eLife, Vol 9 (2020)
Acid-sensing ion channels (ASICs) are proton-gated members of the epithelial sodium channel/degenerin (ENaC/DEG) superfamily of ion channels and are expressed throughout the central and peripheral nervous systems. The homotrimeric splice variant ASIC
Externí odkaz:
https://doaj.org/article/03db86394715445caab0cb76e8c5543e
Publikováno v:
eLife, Vol 7 (2018)
Hearing and balance involve the transduction of mechanical stimuli into electrical signals by deflection of bundles of stereocilia linked together by protocadherin 15 (PCDH15) and cadherin 23 ‘tip links’. PCDH15 transduces tip link tension into o
Externí odkaz:
https://doaj.org/article/813408e384164dd1b862a65a8683e056
Autor:
Swastik Phulera, Hongtao Zhu, Jie Yu, Derek P Claxton, Nate Yoder, Craig Yoshioka, Eric Gouaux
Publikováno v:
eLife, Vol 7 (2018)
Fast inhibitory neurotransmission in the mammalian nervous system is largely mediated by GABAA receptors, chloride-selective members of the superfamily of pentameric Cys-loop receptors. Native GABAA receptors are heteromeric assemblies sensitive to m
Externí odkaz:
https://doaj.org/article/a92fc16f5f7b442fb41ea394d64de88c