Zobrazeno 1 - 10
of 1 947
pro vyhledávání: '"Eric Gershwin"'
Autor:
Hao-Xian Zhu, Shu-Han Yang, Cai-Yue Gao, Zhen-Hua Bian, Xiao-Min Chen, Rong-Rong Huang, Qian-Li Meng, Xin Li, Haosheng Jin, Koichi Tsuneyama, Ying Han, Liang Li, Zhi-Bin Zhao, M. Eric Gershwin, Zhe-Xiong Lian
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Primary biliary cholangitis (PBC) is a cholestatic autoimmune liver disease characterized by autoreactive T cell response against intrahepatic small bile ducts. Here, we use Il12b-/-Il2ra-/- mice (DKO mice) as a model of autoimmune cholangit
Externí odkaz:
https://doaj.org/article/a3208583c2fb4b3fbee865627da0c7c2
Autor:
Mingming Zhang, Zhuye Qin, Yexi Huang, Wenyan Tian, You Li, Chan Wang, Weifeng Zhao, Yaping Dai, Xingjuan Shi, M. Eric Gershwin, Xiong Ma, Meilin Wang, Xiangdong Liu, Weichang Chen, Fang Qiu
Publikováno v:
Journal of Translational Autoimmunity, Vol 8, Iss , Pp 100234- (2024)
The biliary epithelial cells release CC chemokine receptor 6 (CCR6) ligand 20 (CCL20), leading to recruitment of CCR6+ T cells and subsequent infiltration into the biliary epithelium in primary biliary cholangitis patients. Previous genome-wide multi
Externí odkaz:
https://doaj.org/article/24871d533857436dae4755344bbd8d9c
Autor:
Chan Wang, Zhuye Qin, Mingming Zhang, Yaping Dai, Luyao Zhang, Wenyan Tian, Yuhua Gong, Sufang Chen, Can Yang, Ping Xu, Xingjuan Shi, Weifeng Zhao, Suraj Timilsina, M. Eric Gershwin, Weichang Chen, Fang Qiu, Xiangdong Liu
Publikováno v:
Journal of Translational Autoimmunity, Vol 8, Iss , Pp 100239- (2024)
Objectives: Antibodies to gp210 and sp100 are specific and unique anti-nuclear autoantibodies (ANAs) associated with primary biliary cholangitis (PBC). Importantly the presence of anti-gp210 and anti-sp100 responses is indicative of poor clinical out
Externí odkaz:
https://doaj.org/article/49d41df47cb24219af7f218d24f695de
Autor:
You Li, Lu Zhou, Zuxiong Huang, Yue Yang, Jiming Zhang, Ling Yang, Yun Xu, Junping Shi, Shanhong Tang, Xiaoling Yuan, Jie Xu, Yiling Li, Xu Han, Jia Li, Yanmin Liu, Ying Sun, Xiaozhi Jin, Xiao Xiao, Bangmao Wang, Qiuxiang Lin, Yang Zhou, Xuejiao Song, Yong Cui, Lilin Hu, Yuhu Song, Jie Bao, Ling Gong, M. Eric Gershwin, Xianbo Zuo, Huiping Yan, Zhengsheng Zou, Ruqi Tang, Xiong Ma
Publikováno v:
JHEP Reports, Vol 6, Iss 1, Pp 100926- (2024)
Background & Aims: Association studies have greatly refined the important role of the major histocompatibility complex (MHC) region in autoimmune hepatitis (AIH). However, the effects of human leucocyte antigen (HLA) polymorphisms on AIH are not well
Externí odkaz:
https://doaj.org/article/dbd42b753548473c859fa92dc5c5cb33
Autor:
You Li, Zhiqiang Li, Ruiling Chen, Min Lian, Hanxiao Wang, Yiran Wei, Zhengrui You, Jun Zhang, Bo Li, Yikang Li, Bingyuan Huang, Yong Chen, Qiaoyan Liu, Zhuwan Lyu, Xueying Liang, Qi Miao, Xiao Xiao, Qixia Wang, Jingyuan Fang, YongYong Shi, Xiangdong Liu, Michael F. Seldin, M. Eric Gershwin, Ruqi Tang, Xiong Ma
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Primary biliary cholangitis is a rare, chronic immune-mediated liver disease triggered by environmental exposures in genetically susceptible individuals. Here, the authors investigate the functional mechanism underlying the association of 19p13.3 var
Externí odkaz:
https://doaj.org/article/c3bffe3f09684055a2d88786709182d8
Autor:
Yuriy Baglaenko, Catriona Wagner, Vijay G. Bhoj, Petter Brodin, M. Eric Gershwin, Daniel Graham, Pietro Invernizzi, Kenneth K. Kidd, Ilya Korsunsky, Michael Levy, Andrew L. Mammen, Victor Nizet, Francisco Ramirez-Valle, Edward C. Stites, Marc S. Williams, Michael Wilson, Noel R. Rose, Virginia Ladd, Marina Sirota
Publikováno v:
Cambridge Prisms: Precision Medicine, Vol 1 (2023)
Precision Medicine is an emerging approach for disease treatment and prevention that takes into account individual variability in genes, environment, and lifestyle. Autoimmune diseases are those in which the body’s natural defense system loses disc
Externí odkaz:
https://doaj.org/article/bcf797b4c46e41e2bed7e76f1a48f825
Publikováno v:
Journal of Translational Autoimmunity, Vol 6, Iss , Pp 100188- (2023)
Introduction: Primary biliary cholangitis (PBC) is an autoimmune liver disease involving the small intrahepatic bile ducts; when untreated or undertreated, it may evolve to liver fibrosis and cirrhosis. Ursodeoxycholic Acid (UDCA) is the standard of
Externí odkaz:
https://doaj.org/article/12f96960d1e645439f0e8217dc3bc3a5
Autor:
Naohiro Nakamura, Katsunori Yoshida, Rinako Tsuda, Miki Murata, Takashi Yamaguchi, Kanehiko Suwa, Mayuko Ichimura, Koichi Tsuneyama, Koichi Matsuzaki, Toshiaki Nakano, Junko Hirohara, Toshihito Seki, Kazuichi Okazaki, M. Eric Gershwin, Makoto Naganuma
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 26, Iss 12, Pp 1480-1492 (2021)
Introduction: Patients with primary biliary cholangitis (PBC) are at increased risk for development of hepatocellular carcinoma (HCC), particularly in the presence of comorbidities such as excessive alcohol consumption. Although liver fibrosis is an
Externí odkaz:
https://doaj.org/article/a7d28af6620d46afae51be927094cde5
Autor:
M. Eric Gershwin, George C. Tsokos
Since publication of the 4th Edition of The Autoimmune Diseases in 2006, the understanding of the immune mechanisms underlying autoimmunity and autoimmune disease has significantly deepened and broadened. This fully revised 5th Edition incorporates n
Autoimmune diseases are characterized by the occurrence of antibodies reacting with self-constituents of the body. The fully updated third edition of Autoantibodies is an in-depth review of the main autoantibodies identified up to now, with particula