Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Eric Garver"'
Publikováno v:
The Journal of Experimental Medicine
A mutation in the gene encoding for the liver mitochondrial aldehyde dehydrogenase (ALDH2–2), present in some Asian populations, lowers or abolishes the activity of this enzyme and results in elevations in blood acetaldehyde upon ethanol consumptio
Autor:
Qing-na Cao, Yedy Israel, Eric Garver, Feng Zhou, Biddanda C. Ponnappa, Indranil Dey, Guang-chou Tu
Publikováno v:
Scopus-Elsevier
Kupffer cells play a key role in the pathogenesis of liver diseases. Liver injury is believed to result from an excessive release of cytokines and prostanoids from these cells. A targeted delivery of antisense oligonucleotides into Kupffer cells migh
Autor:
William Brian, Eric Garver, Margaret E. Sorenson, Edward F. Webb, Don E. Griswold, Ravi Shanker Garigipati, Jerry L. Adams, Marie Chabot-Fletcher, Schmidt Stanley J, J F Newton, M. N. Tzimas, Lee Ann P. Yodis, John J. Breton, Kathy A. Tyrrell
Publikováno v:
Journal of Medicinal Chemistry. 39:5035-5046
A series of N-hydroxyurea derivatives have been prepared and examined as inhibitors of 5-lipoxygenase. Oral activity was established by examining the inhibition of LTB4 biosynthesis in an ex vivo assay in the mouse. The pharmacodynamic performance in
Autor:
Edward F. Webb, John J. Breton, J F Newton, Eric Garver, M. N. Tzimas, William Brian, Don E. Griswold, Margaret E. Sorenson, Lee Ann P. Yodis, Kathy A. Tyrrell, Ravi Shanker Garigipati, Jerry L. Adams, Marie Chabot-Fletcher, Schmidt Stanley J
Publikováno v:
ChemInform. 28
A series of N-hydroxyurea derivatives have been prepared and examined as inhibitors of 5-lipoxygenase. Oral activity was established by examining the inhibition of LTB4 biosynthesis in an ex vivo assay in the mouse. The pharmacodynamic performance in
Autor:
Anuradha Rao, Chao Han, Tian Lan, Charles B. Davis, Jamie Haywood, Paul A. Dawson, Eric Garver
The macrolide antibiotics azithromycin and clarithromycin are large molecular weight compounds that exhibit moderate to excellent oral bioavailability in preclinical species and humans. Previous concomitant dosing studies in rats using rifamycin SV,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4776980847753f9039aa2f70b2b6e57
https://europepmc.org/articles/PMC2784704/
https://europepmc.org/articles/PMC2784704/
Autor:
Erin D. Hugger, Eric Garver, Chao Han, Shawn P. Shearn, Charles B. Davis, Anuradha Rao, Paul A. Dawson
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 36(12)
Macrolide antibiotics azithromycin (AZI) and clarithromycin (CLARI) are large molecular weight compounds and are substrates for apically polarized efflux transporters such as P-glycoprotein, which can potentially restrict intestinal absorption. Howev
Publikováno v:
Scopus-Elsevier
The screening of new agents for aversive therapy of alcoholism requires a simple animal model. Animals trained to ingest ethanol solutions and subsequently administered a drug known to produce an aversion to ethanol in humans, do not readily make the
Autor:
Christine M. Gardiner, Martha A. Sarpong, Kaushik Raha, Ken A. Newlander, Kurt R. Auger, Steven D. Knight, Cynthia A. Parrish, Lance Ridgers, Glenn S. Van Aller, Carla A. Donatelli, Amita M. Chaudhari, Peter J. Tummino, Schmidt Stanley J, Chiu-Mei Sung, Eric Garver, Jeffrey D. Carson, Michael G. Darcy, Lusong Luo, Dashyant Dhanak, Nicholas D. Adams, Joelle Lorraine Burgess, Patricia A. Elkins, Melody Diamond
Publikováno v:
Molecular Cancer Therapeutics. 8:C62-C62
Phosphoinositide 3-kinase (PI3K) is a critical regulator of cell growth and transformation and its signaling pathway is one of the most commonly mutated pathways in human cancer. The mammalian target of rapamycin (mTOR), a class IV PI3K protein kinas