Výsledky vyhledávání - "Eric Gamazon"

Akademický článek

Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS.

Autor: Dan L Nicolae, Eric Gamazon, Wei Zhang, Shiwei Duan, M Eileen Dolan, Nancy J Cox

Publikováno v: PLoS Genetics, Vol 6, Iss 4, p e1000888 (2010)

Although genome-wide association studies (GWAS) of complex traits have yielded more reproducible associations than had been discovered using any other approach, the loci characterized to date do not account for much of the heritability to such traits

Externí odkaz: https://doaj.org/article/fc3aca6fd6ec4a9aabd90395e72c946d

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Data from A Genome-wide Association Study of Early-Onset Breast Cancer Identifies PFKM as a Novel Breast Cancer Gene and Supports a Common Genetic Spectrum for Breast Cancer at Any Age

Autor: Alice S. Whittemore, Nancy J. Cox, Douglas F. Easton, Dan Nicolae, Fernando Rivadeneira, Andre G. Uitterlinden, Hanne Meijers-Heijboer, Quinten Waisfisz, Paul Pharoah, Alison M. Dunning, Clare Turnbull, Nazneen Rahman, Jianjun Liu, Astrid Irwanto, Kamila Czene, Per Hall, Carl Blomqvist, Kristiina Aittomäki, Heli Nevanlinna, Norbert Dahmen, Dieter Flesch-Janys, Jennifer Stone, Quang Minh Bui, Daniel F. Schmidt, Enes Makalic, Rebecca Hein, Lars Beckmann, Magdalena Lochmann, Bertram Müller-Myhsok, Rita K. Schmutzler, Alfons Meindl, Stephen J. Chanock, David J. Hunter, Mark Lathrop, Isabel dos Santos Silva, Olivia Fletcher, Julian Peto, Daniel J. Park, Carmel Apicella, Kyriaki Michailidou, Polly Newcomb, Noralane M. Lindor, Mark Jenkins, Robert Haile, Steve Gallinger, David Duggan, David Conti, Eunjung Lee, Regina M. Santella, Graham G. Giles, Melissa C. Southey, Julia A. Knight, Graham Casey, Daniela Seminara, Duncan C. Thomas, Marilie D. Gammon, Giske Ursin, Kathi Malone, Esther M. John, John L. Hopper, Irene Andrulis, Jenny Chang-Claude, Stephanie Melkonian, Maria Argos, Rachelle Brutus, Shantanu Roy, Farzana Jasmine, Jianxin Shi, Anna Felberg, Valerie McGuire, Eric Gamazon, Lin Tong, Brandon L. Pierce, Muhammad G. Kibriya, Jerry Halpern, Habibul Ahsan

Early-onset breast cancer (EOBC) causes substantial loss of life and productivity, creating a major burden among women worldwide. We analyzed 1,265,548 Hapmap3 single-nucleotide polymorphisms (SNP) among a discovery set of 3,523 EOBC incident cases a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::447201ac529828c2509e3c7b7268d0a9
https://doi.org/10.1158/1055-9965.c.6515769

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Supplementary Methods, Tables 1 - 6 from A Genome-wide Association Study of Early-Onset Breast Cancer Identifies PFKM as a Novel Breast Cancer Gene and Supports a Common Genetic Spectrum for Breast Cancer at Any Age

PDF file - 197K, Table S1. Discovery set study populations. Table S2. Distribution of discovery set subjects by site, case-control status and chip. Table S3. Discovery set quality control summary. Table S4. SNPs with score-based P-values < 4 X 10-8 a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59da784c5c7f4419931b160e781ad99a
https://doi.org/10.1158/1055-9965.22437186

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Phenome-Wide Scan Identifies Hematologic Traits Associated with Genetically-Determined Expression of BCL-2 Family Genes

Autor: Abigail l. Rich, Philip Lin, Eric Gamazon, Sandra Zinkel

Publikováno v: Blood. 140:10708-10709

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9bcc43151168afe7cf5535c9f0bc8d3e
https://doi.org/10.1182/blood-2022-170632

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Integrative transcriptomic, evolutionary, and causal inference framework for region-level analysis: Application to COVID-19

Autor: Dan Zhou, Eric Gamazon

Publikováno v: npj Genomic Medicine. 7

We developed an integrative transcriptomic, evolutionary, and causal inference framework for a deep region-level analysis, which integrates several published approaches and a new summary-statistics-based methodology. To illustrate the framework, we a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a9f2c22bacd4c5d8a29ce86dcc0007b
https://doi.org/10.1038/s41525-022-00296-y

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