Výsledky vyhledávání - "Eric G. Solon"

SCY-078, a Novel Fungicidal Agent, Demonstrates Distribution to Tissues Associated with Fungal Infections during Mass Balance Studies with Intravenous and Oral [ 14 C]SCY-078 in Albino and Pigmented Rats

Autor: David Angulo, Stephen A. Wring, Katyna Borroto-Esoda, Eric G. Solon

Publikováno v: Antimicrobial Agents and Chemotherapy. 63

SCY-078, a fungicidal β-1,3-glucan synthesis inhibitor administered as intravenous or oral [ 14 C]SCY-078 to rats, was distributed primarily into tissues associated with invasive fungal disease (kidney, lung, liver, spleen, bone marrow, muscle, vagi

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https://doi.org/10.1128/aac.02119-18

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Pharmacokinetics, distribution, metabolism, and excretion of the dual reuptake inhibitor [14C]-nefopam in rats

Autor: Jian Yu, Eric G. Solon, Nishit B. Modi, Aravind Mittur, Helen Shen

Publikováno v: Xenobiotica. 46:1026-1048

1. This study examined the pharmacokinetics, distribution, metabolism, and excretion of [14C] nefopam in rats after a single oral administration. Blood, plasma, and excreta were analyzed for total radioactivity, nefopam, and metabolites. Metabolites

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https://doi.org/10.3109/00498254.2016.1145755

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Use of Radioactive Compounds and Autoradiography to Determine Drug Tissue Distribution

Autor: Eric G Solon

Publikováno v: Chemical Research in Toxicology. 25:543-555

Radioactivity has been used in drug discovery and development for several decades because it offers researchers a highly sensitive way to quantitatively assess the absorption, distribution, metabolism, and/or excretion (ADME) of chemical entities by

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https://doi.org/10.1021/tx200509f

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Autoradiography, MALDI-MS, and SIMS-MS Imaging in Pharmaceutical Discovery and Development

Autor: Brendan Prideaux, Markus Stoeckli, Alain Schweitzer, Eric G. Solon

Publikováno v: The AAPS Journal. 12:11-26

Whole-body autoradiography ((WBA) or quantitative WBA (QWBA)), microautoradiography (MARG), matrix-assisted laser desorption/ionization mass spectrometric imaging (MALDI-MSI), and secondary ion mass spectrometric imaging (SIMS-MSI) are high-resolutio

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https://doi.org/10.1208/s12248-009-9158-4

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Autoradiography: high-resolution molecular imaging in pharmaceutical discovery and development

Autor: Eric G Solon

Publikováno v: Expert Opinion on Drug Discovery. 2:503-514

Autoradiography (ARG) is a powerful, high resolution, quantitative molecular imaging technique used to study the tissue distribution of radiolabeled xenobiotics in biologic models. ARG involves the close apposition of solid specimens containing a rad

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https://doi.org/10.1517/17460441.2.4.503

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Autoradiography techniques and quantification of drug distribution

Autor: Eric G. Solon

Publikováno v: Cell and tissue research. 360(1)

The use of radiolabeled drug compounds offers the most efficient way to quantify the amount of drug and/or drug-derived metabolites in biological samples. Autoradiography is a technique using X- ray film, phosphor imaging plates, beta imaging systems

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https://pubmed.ncbi.nlm.nih.gov/25604842

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Quantitative Imaging Using Autoradiographic Techniques

Autor: Eric G. Solon, Brian R. Moyer

Publikováno v: Pharmaco-Imaging in Drug and Biologics Development ISBN: 9781461482468

Autoradiography (ARG) is a powerful, high resolution, quantitative molecular imaging technique used to study the tissue distribution of radiolabeled xenobiotics in biological models. ARG involves the close apposition of solid specimens containing rad

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https://doi.org/10.1007/978-1-4614-8247-5_6

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Whole-Body Autoradiography and Microautoradiography in Drug Discovery and Development

Autor: Eric G. Solon

Publikováno v: Encyclopedia of Drug Metabolism and Interactions

This chapter describes the following three approaches used to study the tissue distribution of chemical and biological compounds in laboratory animals: (i) organ collection, homogenization/combustion, and liquid scintillation counting (LSC) analysis;

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https://doi.org/10.1002/9780470921920.edm103

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Chapter 6. Autoradiography in Pharmaceutical Discovery and Development

Autor: Eric G. Solon

Autoradiography (ARG) is a powerful, high resolution, quantitative molecular imaging technique used to study the tissue distribution and pharmacokinetics of new radiolabeled chemical entities in biological models. In the classic technique, the radioa

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https://doi.org/10.1039/9781849732918-00309

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