Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Eric G. Solon"'
Autor:
Eric G. Solon
Publikováno v:
Visualizing and Quantifying Drug Distribution in Tissue IV.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da300102a7938bd5120715b787f0b895
https://doi.org/10.1117/12.2551441
https://doi.org/10.1117/12.2551441
Publikováno v:
Antimicrobial Agents and Chemotherapy. 63
SCY-078, a fungicidal β-1,3-glucan synthesis inhibitor administered as intravenous or oral [ 14 C]SCY-078 to rats, was distributed primarily into tissues associated with invasive fungal disease (kidney, lung, liver, spleen, bone marrow, muscle, vagi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db1dc3469e1901573d047972552fe5c5
https://doi.org/10.1128/aac.02119-18
https://doi.org/10.1128/aac.02119-18
Publikováno v:
Xenobiotica. 46:1026-1048
1. This study examined the pharmacokinetics, distribution, metabolism, and excretion of [14C] nefopam in rats after a single oral administration. Blood, plasma, and excreta were analyzed for total radioactivity, nefopam, and metabolites. Metabolites
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::566d4e4bbd843ff8cd781688f882655b
https://doi.org/10.3109/00498254.2016.1145755
https://doi.org/10.3109/00498254.2016.1145755
Autor:
Eric G Solon
Publikováno v:
Chemical Research in Toxicology. 25:543-555
Radioactivity has been used in drug discovery and development for several decades because it offers researchers a highly sensitive way to quantitatively assess the absorption, distribution, metabolism, and/or excretion (ADME) of chemical entities by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e856f299e1d8edff7407c3b3501b77ba
https://doi.org/10.1021/tx200509f
https://doi.org/10.1021/tx200509f
Publikováno v:
The AAPS Journal. 12:11-26
Whole-body autoradiography ((WBA) or quantitative WBA (QWBA)), microautoradiography (MARG), matrix-assisted laser desorption/ionization mass spectrometric imaging (MALDI-MSI), and secondary ion mass spectrometric imaging (SIMS-MSI) are high-resolutio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c36ba931223aa4b7480d784338b31c50
https://doi.org/10.1208/s12248-009-9158-4
https://doi.org/10.1208/s12248-009-9158-4
Autor:
Eric G Solon
Publikováno v:
Expert Opinion on Drug Discovery. 2:503-514
Autoradiography (ARG) is a powerful, high resolution, quantitative molecular imaging technique used to study the tissue distribution of radiolabeled xenobiotics in biologic models. ARG involves the close apposition of solid specimens containing a rad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d39b4cf76f8daed14e96e6d4151272a
https://doi.org/10.1517/17460441.2.4.503
https://doi.org/10.1517/17460441.2.4.503
Autor:
Eric G. Solon
Publikováno v:
Cell and tissue research. 360(1)
The use of radiolabeled drug compounds offers the most efficient way to quantify the amount of drug and/or drug-derived metabolites in biological samples. Autoradiography is a technique using X- ray film, phosphor imaging plates, beta imaging systems
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59c53c5871d03eeb1209e8398bf09b89
https://pubmed.ncbi.nlm.nih.gov/25604842
https://pubmed.ncbi.nlm.nih.gov/25604842
Autor:
Eric G. Solon, Brian R. Moyer
Publikováno v:
Pharmaco-Imaging in Drug and Biologics Development ISBN: 9781461482468
Autoradiography (ARG) is a powerful, high resolution, quantitative molecular imaging technique used to study the tissue distribution of radiolabeled xenobiotics in biological models. ARG involves the close apposition of solid specimens containing rad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::323ae524710bf5003fa65151b04c3bda
https://doi.org/10.1007/978-1-4614-8247-5_6
https://doi.org/10.1007/978-1-4614-8247-5_6
Autor:
Eric G. Solon
Publikováno v:
Encyclopedia of Drug Metabolism and Interactions
This chapter describes the following three approaches used to study the tissue distribution of chemical and biological compounds in laboratory animals: (i) organ collection, homogenization/combustion, and liquid scintillation counting (LSC) analysis;
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fef4a8a68841c8c962680785d745336d
https://doi.org/10.1002/9780470921920.edm103
https://doi.org/10.1002/9780470921920.edm103
Autor:
Eric G. Solon
Autoradiography (ARG) is a powerful, high resolution, quantitative molecular imaging technique used to study the tissue distribution and pharmacokinetics of new radiolabeled chemical entities in biological models. In the classic technique, the radioa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a655a07683a95073c3fe0197e1245f2
https://doi.org/10.1039/9781849732918-00309
https://doi.org/10.1039/9781849732918-00309