Complexity and Diversity of the Mammalian Sialome Revealed by Nidovirus Virolectins

Autor: Martijn A. Langereis, Mark J.G. Bakkers, Lingquan Deng, Vered Padler-Karavani, Stephin J. Vervoort, Ruben J.G. Hulswit, Arno L.W. van Vliet, Gerrit J. Gerwig, Stefanie A.H. de Poot, Willemijn Boot, Anne Marie van Ederen, Balthasar A. Heesters, Chris M. van der Loos, Frank J.M. van Kuppeveld, Hai Yu, Eric G. Huizinga, Xi Chen, Ajit Varki, Johannis P. Kamerling, Raoul J. de Groot

Publikováno v: Cell Reports, Vol 11, Iss 12, Pp 1966-1978 (2015)

Sialic acids (Sias), 9-carbon-backbone sugars, are among the most complex and versatile molecules of life. As terminal residues of glycans on proteins and lipids, Sias are key elements of glycotopes of both cellular and microbial lectins and thus act

Externí odkaz: https://doaj.org/article/c810e7e811be4ad3b07b1a33d7f7d1fb

Erythrocytosis associated with a novel missense mutation in the HIF2A gene

Autor: Richard van Wijk, Scott Sutherland, Annet C.W. Van Wesel, Eric G. Huizinga, Melanie J. Percy, Marc Bierings, Frank S. Lee

Publikováno v: Haematologica, Vol 95, Iss 5 (2010)

The ERYTHROPOIETIN (EPO) gene is regulated by the transcription factor Hypoxia Inducible Factor-α (HIF-α). In this pathway, Prolyl Hydroxylase Domain protein 2 (PHD2) hydroxylates two prolyl residues in HIF-α, which in turn promotes HIF-α degrada

Externí odkaz: https://doaj.org/article/3ea51289ec9a4bcb974be0f464617031

Human coronaviruses OC43 and HKU1 bind to 9

Autor: Ruben J G, Hulswit, Yifei, Lang, Mark J G, Bakkers, Wentao, Li, Zeshi, Li, Arie, Schouten, Bram, Ophorst, Frank J M, van Kuppeveld, Geert-Jan, Boons, Berend-Jan, Bosch, Eric G, Huizinga, Raoul J, de Groot

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 116(7)

Human betacoronaviruses OC43 and HKU1 are endemic respiratory pathogens and, while related, originated from independent zoonotic introductions. OC43 is in fact a host-range variant of the species Betacoronavirus-1, and more closely related to bovine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b2a023b1a4fd9b3ed8c1568766072492
https://pubmed.ncbi.nlm.nih.gov/30679277

Molecular basis determining species specificity for TLR2 inhibition by staphylococcal superantigen-like protein 3 (SSL3)

Autor: Alex J. McCarthy, Adinda Bisschop, Eric G. Huizinga, Louris J. Feitsma, Kirsten J. Koymans, Jos A. G. van Strijp, Carla J. C. de Haas

Publikováno v: Veterinary Research
Veterinary Research, BioMed Central, 2018, 49 (1), pp.115. ⟨10.1186/s13567-018-0609-8⟩
Veterinary Research, Vol 49, Iss 1, Pp 1-15 (2018)

Staphylococcus aureus is a versatile opportunistic pathogen, causing disease in human and animal species. Its pathogenicity is linked to the ability of S. aureus to secrete immunomodulatory molecules. These evasion proteins bind to host receptors or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bd9f4ff032710b457f0e9c539e3d8ba
http://hdl.handle.net/10044/1/72102

Formation and Structure of a NAIP5-NLRC4 Inflammasome Induced by Direct Interactions with Conserved N- and C-terminal Regions of Flagellin

Autor: Els F. Halff, Arie Schouten, Eric G. Huizinga, Marian Versteeg, Christoph A. Diebolder, T. Harma C. Brondijk

Publikováno v: Journal of Biological Chemistry. 287:38460-38472

The NOD-like receptors NAIP5 and NLRC4 play an essential role in the innate immune response to the bacterial tail protein flagellin. Upon flagellin detection, NAIP5 and NLRC4 form a hetero-oligomeric inflammasome that induces caspase-1-dependent cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4488af9e012f759cfd3cd09cc7eced3b
https://doi.org/10.1074/jbc.m112.393512