Výsledky vyhledávání - "Eric G Huizinga"

Akademický článek

TLR accessory molecule RP105 (CD180) is involved in post-interventional vascular remodeling and soluble RP105 modulates neointima formation.

Autor: Jacco C Karper, Mark M Ewing, Margreet R de Vries, Saskia C A de Jager, Erna A B Peters, Hetty C de Boer, Anton-Jan van Zonneveld, Johan Kuiper, Eric G Huizinga, T Harma C Brondijk, J Wouter Jukema, Paul H A Quax

Publikováno v: PLoS ONE, Vol 8, Iss 7, p e67923 (2013)

BackgroundRP105 (CD180) is TLR4 homologue lacking the intracellular TLR4 signaling domain and acts a TLR accessory molecule and physiological inhibitor of TLR4-signaling. The role of RP105 in vascular remodeling, in particular post-interventional rem

Externí odkaz: https://doaj.org/article/5e9b2f2b8334475e8db514960d63fb13

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Akademický článek

The murine coronavirus hemagglutinin-esterase receptor-binding site: a major shift in ligand specificity through modest changes in architecture.

Autor: Martijn A Langereis, Qinghong Zeng, Balthasar A Heesters, Eric G Huizinga, Raoul J de Groot

Publikováno v: PLoS Pathogens, Vol 8, Iss 1, p e1002492 (2012)

The hemagglutinin-esterases (HEs), envelope glycoproteins of corona-, toro- and orthomyxoviruses, mediate reversible virion attachment to O-acetylated sialic acids (O-Ac-Sias). They do so through concerted action of distinct receptor-binding ("lectin

Externí odkaz: https://doaj.org/article/74eb25750aeb41d0a02f0260c2fac657

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Akademický článek

A rapid cloning method employing orthogonal end protection.

Autor: Arjen J Jakobi, Eric G Huizinga

Publikováno v: PLoS ONE, Vol 7, Iss 6, p e37617 (2012)

We describe a novel in vitro cloning strategy that combines standard tools in molecular biology with a basic protecting group concept to create a versatile framework for the rapid and seamless assembly of modular DNA building blocks into functional o

Externí odkaz: https://doaj.org/article/b599adf1e91942e4af715ebd93a6a3b0

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Structural insights into collagen binding by platelet receptor glycoprotein VI

Autor: Louris J. Feitsma, Harma C. Brondijk, Gavin E. Jarvis, Dominique Hagemans, Dominique Bihan, Natasia Jerah, Marian Versteeg, Richard W. Farndale, Eric G. Huizinga

Publikováno v: Blood. 139:3087-3098

Glycoprotein VI (GPVI) mediates collagen-induced platelet activation after vascular damage and is an important contributor to the onset of thrombosis, heart attack, and stroke. Animal models of thrombosis have identified GPVI as a promising target fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77178e06598c94741629f8e701058272
https://doi.org/10.1182/blood.2021013614

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Akademický článek

Erythrocytosis associated with a novel missense mutation in the HIF2A gene

Autor: Richard van Wijk, Scott Sutherland, Annet C.W. Van Wesel, Eric G. Huizinga, Melanie J. Percy, Marc Bierings, Frank S. Lee

Publikováno v: Haematologica, Vol 95, Iss 5 (2010)

The ERYTHROPOIETIN (EPO) gene is regulated by the transcription factor Hypoxia Inducible Factor-α (HIF-α). In this pathway, Prolyl Hydroxylase Domain protein 2 (PHD2) hydroxylates two prolyl residues in HIF-α, which in turn promotes HIF-α degrada

Externí odkaz: https://doaj.org/article/3ea51289ec9a4bcb974be0f464617031

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Human coronaviruses OC43 and HKU1 bind to 9

Autor: Ruben J G, Hulswit, Yifei, Lang, Mark J G, Bakkers, Wentao, Li, Zeshi, Li, Arie, Schouten, Bram, Ophorst, Frank J M, van Kuppeveld, Geert-Jan, Boons, Berend-Jan, Bosch, Eric G, Huizinga, Raoul J, de Groot

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 116(7)

Human betacoronaviruses OC43 and HKU1 are endemic respiratory pathogens and, while related, originated from independent zoonotic introductions. OC43 is in fact a host-range variant of the species Betacoronavirus-1, and more closely related to bovine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b2a023b1a4fd9b3ed8c1568766072492
https://pubmed.ncbi.nlm.nih.gov/30679277

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Cryoelectron Tomography of the NAIP5/NLRC4 Inflammasome: Implications for NLR Activation

Autor: Eric G. Huizinga, Els F. Halff, Christoph A. Diebolder, Roman I. Koning, Abraham J. Koster

Publikováno v: Structure, 23(12), 2349-2357

SummaryInflammasomes are high molecular weight protein complexes that play a crucial role in innate immunity by activating caspase-1. Inflammasome formation is initiated when molecules originating from invading microorganisms activate nucleotide-bind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f11fd7023ded32cee2435aaee2fe69d2

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Molecular basis determining species specificity for TLR2 inhibition by staphylococcal superantigen-like protein 3 (SSL3)

Autor: Alex J. McCarthy, Adinda Bisschop, Eric G. Huizinga, Louris J. Feitsma, Kirsten J. Koymans, Jos A. G. van Strijp, Carla J. C. de Haas

Publikováno v: Veterinary Research
Veterinary Research, BioMed Central, 2018, 49 (1), pp.115. ⟨10.1186/s13567-018-0609-8⟩
Veterinary Research, Vol 49, Iss 1, Pp 1-15 (2018)

Staphylococcus aureus is a versatile opportunistic pathogen, causing disease in human and animal species. Its pathogenicity is linked to the ability of S. aureus to secrete immunomodulatory molecules. These evasion proteins bind to host receptors or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bd9f4ff032710b457f0e9c539e3d8ba
http://hdl.handle.net/10044/1/72102

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