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683 A novel mechanism of neuropilin-1 inhibition results in improved tumor growth inhibition in vivo
Autor:
Chengfeng Merriman, Aaron Fulgham, Mandana Abbassi, Alexandria Fink, Pearl S. Huang, Jonathan Hurov, Andrew Rogantino, Tiffany Liao, Eric Franklin Zhu, Hongyue Dai, Daniel Blom, Shalini Sethumadhavan, Ameya Apte, Katherine Molloy, Shan Lou
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Neuropilin-1 (NRP1) is a co-receptor that complexes with diverse ligands and their cognate receptors. As such, it plays a role in multiple different biological processes, including axon guidance and angiogenesis. NRP1 contains two CUB doma