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pro vyhledávání: '"Eric Fluharty"'
Autor:
Adriana T. Larregina, Eric Fluharty, Yvonne K. Mburu, Alicia R. Mathers, Robert L. Ferris, Louis D. Falo, Laura K. Ferris
Publikováno v:
The Journal of investigative dermatology
Human beta-defensins (hBDs) are antimicrobial peptides that have an important role in innate immune responses at epithelial barriers such as the skin. However, the role that hBDs have in initiating cellular immune responses that contribute to antigen
Publikováno v:
Journal of Biological Chemistry. 283:36636-36645
The production of phosphatidic acid plays a crucial role in the activation of the ERK cascade. This role was linked to the binding of phosphatidate to a specific polybasic site within the kinase domain of Raf-1. Here we show that phosphatidate promot
Autor:
Raul Rojas, Lorraine C. Santy, Guillermo Romero, Megan A. Rizzo, Eric Fluharty, James E. Casanova, Kuntala Shome, Hai-sheng Li, Chandrasekaran Vasudevan
Publikováno v:
BMC Cell Biology
BMC Cell Biology, Vol 4, Iss 1, p 13 (2003)
BMC Cell Biology, Vol 4, Iss 1, p 13 (2003)
Background Phospholipase D (PLD) is involved in many signaling pathways. In most systems, the activity of PLD is primarily regulated by the members of the ADP-Ribosylation Factor (ARF) family of GTPases, but the mechanism of activation of PLD and ARF