Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Eric Ferrari"'
Autor:
Éric FERRARI
« Depuis toujours, l'homme construit. C'est l'un des plus puissants témoignages du pouvoir qu'il exerce sur le monde. » Éric Ferrari, Président de Fayat Bâtiment, a pris la plume afin de rendre ses lettres de noblesse à une profession sécul
In Vitro Antiviral Profile of Ruzasvir, a Potent and Pangenotype Inhibitor of Hepatitis C Virus NS5A
Autor:
Wensheng Yu, Joseph A. Kozlowski, Stuart Black, Robert Chase, Paul Ingravallo, Ling Tong, Sony Agrawal, Eric Ferrari, Patricia McMonagle, Karin Bystol, Donna Carr, Ernest Asante-Appiah, Frederick C. Lahser, Laura Rokosz, Rong Liu, Stephanie Curry
Publikováno v:
Antimicrobial Agents and Chemotherapy. 62
Inhibition of NS5A has emerged as an attractive strategy to intervene in hepatitis C virus (HCV) replication. Ruzasvir (formerly MK-8408) was developed as a novel NS5A inhibitor to improve upon the potency and barrier to resistance of early compounds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::944a382870f51dc543862102d935e91a
https://doi.org/10.1128/aac.01280-18
https://doi.org/10.1128/aac.01280-18
Autor:
Yuhua Huang, Wang Lingyan, Ann E. Weber, Ian W. Davies, Hsueh-Cheng Huang, Mary Senior, Frank Bennett, Quang T. Truong, Stephane L. Bogen, Asra Malikzay, Rebecca Osterman, Eric Ferrari, Paul Tawa, Elizabeth Smith, Haiyan Pu, Vinay Girijavallabhan, Angela Kerekes, Jun Wang, Alexei V. Buevich
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(23)
(2′R)-Ethynyl uridine 3, and its (2′S)-diastereomer 10, are synthesised in a divergent fashion from the inexpensive parent nucleoside. Both nucleoside analogues are obtained from a total of 5 simple synthetic steps and 3 trivial column chromatogr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37e4b5ff6ec093c3be10484d16116fae
https://pubmed.ncbi.nlm.nih.gov/29056248
https://pubmed.ncbi.nlm.nih.gov/29056248
Autor:
Stuart B. Rosenblum, Stephen Gavalas, Francisco Velazquez, Pinto Patrick A, Oleg Selyutin, Neng-Yang Shih, Yuhua Huang, Wanli Wu, Sony Agrawal, Yueheng Jiang, Srikanth Venkatraman, Joseph A. Kozlowski, Chuan-kui Jiang, Hsueh-Cheng Huang, Jose S. Duca, Anilkumar G. Nair, Bancha Vibulbhan, Eric Ferrari, Kevin X. Chen, Cheng Li, Charles A. Lesburg, F. George Njoroge, Frank Bennett, Qingbei Zeng
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:2007-2017
The characterization of HCV genome has identified various vital functional proteins involved in the life cycle of hepatitis C virus. This has resulted in many novel enzymatic targets that are potential for development of therapeutic agents. The HCV R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f016854d014a0a4d91a3500623598032
https://doi.org/10.1016/j.bmc.2013.01.024
https://doi.org/10.1016/j.bmc.2013.01.024
Publikováno v:
Journal of Virology. 74:2017-2022
RNA-dependent RNA polymerase (RdRp) encoded by positive-strand RNA viruses is critical to the replication of viral RNA genome. Like other positive-strand RNA viruses, replication of hepatitis C virus (HCV) RNA is mediated through a negative-strand in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::598d698b002d26c1e8c1b96e1f824eea
https://doi.org/10.1128/jvi.74.4.2017-2022.2000
https://doi.org/10.1128/jvi.74.4.2017-2022.2000
Autor:
Vicky C. H. Lai, Zhi Hong, Justin J. Park, Annette S. Uss, Johnson Y. N. Lau, Eric Ferrari, Jacquelyn Wright-Minogue, C. Cheng Kao
Publikováno v:
Journal of Virology. 73:10129-10136
Recombinant bovine viral diarrhea virus (BVDV) nonstructural protein 5B (NS5B) produced in insect cells has been shown to possess an RNA-dependent RNA polymerase (RdRp) activity. Our initial attempt to produce the full-length BVDV NS5B with a C-termi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::573cbb18ec099b435aab87b077998a76
https://doi.org/10.1128/jvi.73.12.10129-10136.1999
https://doi.org/10.1128/jvi.73.12.10129-10136.1999
SCH 43478 and analogs: in vitro activity and in vivo efficacy of novel agents for herpesvirus type 2
Autor:
Ann D. Kwong, Eric Ferrari, Randi Albin, Gilbert Jirau-Lucca, Christine Risano, Edward J Rozthon, Angela Skelton, Jacquelyn Wright-Minogue, Demartino Jason L, Melvin Lieberman, Robert Chase, Stuart Cox, Adrian Afonso, Joseph M. Kelly, Peter Buontempo, John O'Connell
Publikováno v:
Antiviral Research. 35:139-146
SCH 43478 and analogs are a class of non-nucleoside antiviral agents that have potent and selective activity against herpes simplex virus type 2 (HSV-2). The IC50 for these compounds in plaque reduction analysis using Vero cells ranges from 0.8 to 2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36bae380c45e196ba43c78fed69edf04
https://doi.org/10.1016/s0166-3542(97)00023-5
https://doi.org/10.1016/s0166-3542(97)00023-5
Autor:
Tin-Yau Chan, Frank Bennett, David Hesk, Qingbei Zeng, Li Wang, Pinto Patrick A, Jennifer J. Gesell, Jose S. Duca, Neng-Yang Shih, Kevin X. Chen, Yuhua Huang, Bancha Vibulbhan, Yueheng Jiang, Sony Agrawal, Oleg Selyutin, Steve Sorota, Haiyan Pu, Hsueh-Cheng Huang, Joseph A. Kozlowski, Charles A. Lesburg, Francisco Velazquez, Stephen Gavalas, Cheng Li, Anilkumar G. Nair, Eric Ferrari, F. George Njoroge, Srikanth Venkatraman, Chuan-kui Jiang, Mousumi Sannigrahi, Stuart B. Rosenblum
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(24)
The discovery of lead compound 2e was described. Its covalent binding to HCV NS5B polymerase enzyme was investigated by X-ray analysis. The results of distribution, metabolism and pharmacokinetics were reported. Compound 2e was demonstrated to be pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e04eb82ee6ce4c43fa35b72c72cd7bb9
https://pubmed.ncbi.nlm.nih.gov/24252545
https://pubmed.ncbi.nlm.nih.gov/24252545
Autor:
Yueheng Jiang, Frank Bennett, Eric Ferrari, Jose S. Duca, Yuhua Huang, Bancha Vibulbhan, Hsueh-Cheng Huang, Oleg Selyutin, Kevin X. Chen, F. George Njoroge, Francisco Velazquez, Stuart B. Rosenblum, Cheng Li, Neng-Yang Shih, Joseph A. Kozlowski, Charles A. Lesburg, Pinto Patrick A, Wanli Wu, Anilkumar G. Nair, Sony Agrawal, Chuan-kui Jiang, Larry Heimark, Srikanth Venkatraman, Stephen Gavalas, Qingbei Zeng
Publikováno v:
Bioorganicmedicinal chemistry. 22(1)
HCV infections are the leading causes for hepatocellular carcinoma and liver transplantation in the United States. Recent advances in drug discovery have identified direct acting antivirals which have significantly improved cure rates in patients. Cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae8528b5ecd0188d3d6346727d7e5565
https://pubmed.ncbi.nlm.nih.gov/24275348
https://pubmed.ncbi.nlm.nih.gov/24275348
Autor:
Eric, Ferrari, Hsueh-Cheng, Huang
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1030
The hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase is essential for viral replication and a clinically validated antiviral target. Discovery of HCV polymerase inhibitors is greatly facilitated by the availability of a suitable biochemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::73d79e6cafb0d8f78d73f1f0752cabca
https://pubmed.ncbi.nlm.nih.gov/23821261
https://pubmed.ncbi.nlm.nih.gov/23821261