Dynamical modeling of the H3K27 epigenetic landscape in mouse embryonic stem cells.

Autor: Kapil Newar, Amith Zafal Abdulla, Hossein Salari, Eric Fanchon, Daniel Jost

Publikováno v: PLoS Computational Biology, Vol 18, Iss 9, p e1010450 (2022)

The Polycomb system via the methylation of the lysine 27 of histone H3 (H3K27) plays central roles in the silencing of many lineage-specific genes during development. Recent experimental evidence suggested that the recruitment of histone modifying en

Externí odkaz: https://doaj.org/article/c836880648214550a3d683c03ccc4dfd

HepatoDyn: A Dynamic Model of Hepatocyte Metabolism That Integrates 13C Isotopomer Data.

Autor: Carles Foguet, Silvia Marin, Vitaly A Selivanov, Eric Fanchon, Wai-Nang Paul Lee, Joan J Guinovart, Pedro de Atauri, Marta Cascante

Publikováno v: PLoS Computational Biology, Vol 12, Iss 4, p e1004899 (2016)

The liver performs many essential metabolic functions, which can be studied using computational models of hepatocytes. Here we present HepatoDyn, a highly detailed dynamic model of hepatocyte metabolism. HepatoDyn includes a large metabolic network,

Externí odkaz: https://doaj.org/article/590fe85107d54419aa985020ca776596

Systems Biology, Systems Medicine, Systems Pharmacology: The What and The Why

Autor: Angélique Stéphanou, Pasquale F. Innominato, Eric Fanchon, Annabelle Ballesta

Publikováno v: Acta Biotheoretica
Acta Biotheoretica, Springer Verlag, 2018, 66 (4), pp.345-365. ⟨10.1007/s10441-018-9330-2⟩
HAL
Acta Biotheoretica, 2018, 66 (4), pp.345-365. ⟨10.1007/s10441-018-9330-2⟩

International audience; Systems biology is today such a widespread discipline that it becomes difficult to propose a clear definition of what it really is. For some, it remains restricted to the genomic field. For many, it designates the integrated a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b1495571e9519d18c9b4a0894d5cb94
https://doi.org/10.1007/s10441-018-9330-2

Multi-scale Modelling of Erythropoiesis and Hemoglobin Production

Autor: Eric Fanchon, Vitaly Volpert, Mark J. Koury, Alexandre Rocca, Jean-Marc Moulis, Anass Bouchnita

Publikováno v: Journal of Inorganic and Organometallic Polymers and Materials
Journal of Inorganic and Organometallic Polymers and Materials, 2016, 26 (6), pp.1362-1379. ⟨10.1007/s10904-016-0437-0⟩
Journal of Inorganic and Organometallic Polymers and Materials, Springer Verlag (Germany), 2016, 26 (6), pp.1362-1379. ⟨10.1007/s10904-016-0437-0⟩

The paper is devoted to multi-scale modelling of erythropoiesis and hemoglobin production. Red blood cells, which carry oxygen from the lungs to the other body tissues, are produced in the bone marrow of adult humans in cell units called erythroblast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69a32eb0374bfeb57891bff216046409
https://doi.org/10.1007/s10904-016-0437-0

Iron for proliferation of cell lines and hematopoietic progenitors: Nailing down the intracellular functional iron concentration

Autor: Nicolas Mobilia, Josiane Arnaud, Eric Fanchon, Marine Lénon, Jean-Yves Cahn, Pascal Mossuz, Jean-Marc Moulis, Emmanuel Pourcelot

Publikováno v: Biochimica et Biophysica Acta-Molecular Cell Research
Biochimica et Biophysica Acta-Molecular Cell Research, Elsevier, 2015, 1853 (7), pp.1596-1605. ⟨10.1016/j.bbamcr.2015.03.009⟩
Biochimica et Biophysica Acta-Molecular Cell Research, 2015, 1853 (7), pp.1596-1605. ⟨10.1016/j.bbamcr.2015.03.009⟩

Iron is an essential nutrient which must be provided in sufficient amounts to support growth of eukaryotic cells. All organisms devote specialized pathways to ensure proper delivery. Yet, a quantitative assessment of the intra-cellular iron concentra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91501c688490050407fb7cc46fb0047a