Next-generation risk assessment read-across case study: application of a 10-step framework to derive a safe concentration of daidzein in a body lotion

Autor: Abdulkarim Najjar, Jochen Kühnl, Daniela Lange, Camille Géniès, Carine Jacques, Eric Fabian, Anne Zifle, Nicola J. Hewitt, Andreas Schepky

Publikováno v: Frontiers in Pharmacology, Vol 15 (2024)

Introduction: We performed an exposure-based Next Generation Risk Assessment case read-across study using New Approach Methodologies (NAMs) to determine the highest safe concentration of daidzein in a body lotion, based on its similarities with its s

Externí odkaz: https://doaj.org/article/da1994c1f9ce46a6a0656cab9deda374

Predictive Performance of Next Generation Physiologically Based Kinetic (PBK) Model Predictions in Rats Based on In Vitro and In Silico Input Data

Autor: Ans Punt, Jochem Louisse, Nicole Pinckaers, Eric Fabian, Bennard van Ravenzwaay

Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology, 186(1), 18-28
Toxicological sciences : an official journal of the Society of Toxicology 186 (2022) 1

The goal of the present study was to assess the predictive performance of a minimal generic rat physiologically based kinetic (PBK) model based on in vitro and in silico input data to predict peak plasma concentrations (Cmax) upon single oral dosing.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe56a13ffa9a2b9c8bc79caf0c0ef1c6
https://doi.org/10.1093/toxsci/kfab150

Novel testing strategy for prediction of rat biliary excretion of intravenously administered estradiol-17β glucuronide

Autor: Bennard van Ravenzwaay, Ivonne M.C.M. Rietjens, Eric Fabian, Annelies Noorlander

Publikováno v: Archives of Toxicology 95 (2021)
Archives of Toxicology, 95, 91-102
Archives of Toxicology

The aim of the present study was to develop a generic rat physiologically based kinetic (PBK) model that includes a novel testing strategy where active biliary excretion is incorporated using estradiol-17β glucuronide (E217βG) as the model substanc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f18473a757292ffeb4018c8f8de799e7
https://doi.org/10.1007/s00204-020-02908-x

Enigmatic mechanism of the N-vinylpyrrolidone hepatocarcinogenicity in the rat

Autor: Franz Oesch, Eric Fabian, Daniela Fruth, Jan G. Hengstler, Franz Ingo Berger, Robert Landsiedel

Publikováno v: Archives of toxicology, 95(12):3717–3744
Archives of Toxicology

N-vinyl pyrrolidone (NVP) is produced up to several thousand tons per year as starting material for the production of polymers to be used in pharmaceutics, cosmetics and food technology. Upon inhalation NVP was carcinogenic in the rat, liver tumor fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dba1ca17777a99a3a16d07bef8fea76
https://repository.publisso.de/resource/frl:6432213

Afidopyropen: Challenges and impact of a toxicokinetic study designed to identify a point of inflection from dose-proportionality

Autor: Anne E. Loccisano, Brandy Riffle, Markus Frericks, Ivana Fegert, Eric Fabian, Elaine Freeman, Adriana M. Doi

Publikováno v: Regulatory Toxicology and Pharmacology. 124:104962

Afidopyropen is an insecticide that acts as a transient receptor potential vanilloid subtype (TRPV) channel modulator in chordotonal organs of target insects and has been assessed for a wide range of toxicity endpoints including chronic toxicity and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f367635cdb683c27863df34e3b898af
https://doi.org/10.1016/j.yrtph.2021.104962