Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Eric F. Tewalt"'
Autor:
Victor H. Engelhard, Andrew R. Ferguson, Randal K. Gregg, Eric F. Tewalt, J. David Peske, Arun B. Dutta, Jianhao Zeng, Nithya Srivinisan, Ashley L. Wilson, Amber N. Woods
Although CD8+ T cells are critical for controlling tumors, how they are recruited and home to primary and metastatic lesions is incompletely understood. We characterized the homing receptor (HR) ligands on tumor vasculature to determine what drives t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0edc53b1657573a41e255b84f0d5afb
https://doi.org/10.1158/2326-6066.c.6548726.v1
https://doi.org/10.1158/2326-6066.c.6548726.v1
Autor:
Victor H. Engelhard, Andrew R. Ferguson, Randal K. Gregg, Eric F. Tewalt, J. David Peske, Arun B. Dutta, Jianhao Zeng, Nithya Srivinisan, Ashley L. Wilson, Amber N. Woods
S1: LLC-OVA or MC-38-OVA tumors were harvested on day 14 (SC) or day 11 (IP). LLC-OVA tumors were flash frozen and stained for MadCAM-1 expression. Representative and summary data interrogating 8-10 random fields from single sections of 3 tumors each
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::281d96743aff82c3ec8629a0e778f316
https://doi.org/10.1158/2326-6066.22538255.v1
https://doi.org/10.1158/2326-6066.22538255.v1
Autor:
Jarish N Cohen, Eric F Tewalt, Sherin J Rouhani, Erica L Buonomo, Amber N Bruce, Xiaojiang Xu, Stefan Bekiranov, Yang-Xin Fu, Victor H Engelhard
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87740 (2014)
Peripheral self-tolerance eliminates lymphocytes specific for tissue-specific antigens not encountered in the thymus. Recently, we demonstrated that lymphatic endothelial cells in mice directly express peripheral tissue antigens, including tyrosinase
Externí odkaz:
https://doaj.org/article/38c5d3067d0744d68f5204b2af509b13
Autor:
Randal K. Gregg, Eric F. Tewalt, Amber N. Woods, Jianhao Zeng, Victor H. Engelhard, Nithya Srivinisan, J. David Peske, Ashley Wilson, Arun B. Dutta, Andrew R. Ferguson
Publikováno v:
Cancer Immunology Research. 5:1062-1073
Although CD8+ T cells are critical for controlling tumors, how they are recruited and home to primary and metastatic lesions is incompletely understood. We characterized the homing receptor (HR) ligands on tumor vasculature to determine what drives t
Autor:
Eric F Tewalt, Jean M Grant, Erica L Granger, Douglas C Palmer, Neal D Heuss, Dale S Gregerson, Nicholas P Restifo, Christopher C Norbury
Publikováno v:
PLoS Pathogens, Vol 5, Iss 5, p e1000457 (2009)
Virus-specific CD8(+) T cells (T(CD8+)) are initially triggered by peptide-MHC Class I complexes on the surface of professional antigen presenting cells (pAPC). Peptide-MHC complexes are produced by two spatially distinct pathways during virus infect
Externí odkaz:
https://doaj.org/article/0c88fc6736a94c98b98d402d66bd3a91
Autor:
Roxana del Rio, Stephen Tardif, Karen Wheeler, Victor H. Engelhard, Brian Luu, Kenneth S. K. Tung, Cory Teuscher, Hui Qiao, Sarah Jeffrey, Daniel M. Hardy, Claudia Rival, Eric F. Tewalt
Publikováno v:
Journal of Reproductive Immunology. 100:66-75
CD4+CD25+ regulatory T cells (Tregs) strongly influence the early and late autoimmune responses to meiotic germ cell antigens (MGCA) and the gonadal immunopathology in vasectomized mice. This is supported by the published and recently acquired inform
Autor:
Cynthia J. Guidi, Hui Qiao, Andrew G. Farr, Kenneth S. K. Tung, Sherin J. Rouhani, Victor H. Engelhard, Alanna Ruddell, Eric F. Tewalt, Jarish N. Cohen
Publikováno v:
The Journal of Experimental Medicine
Peripheral immune tolerance is generally thought to result from cross-presentation of tissue-derived proteins by quiescent tissue-resident dendritic cells to self-reactive T cells that have escaped thymic negative selection, leading to anergy or dele
Autor:
Christopher V. Nicchitta, Amanda M. Schell, Eric F. Tewalt, Christopher C. Norbury, Jason C. Maynard, Brent Berwin, Julie Jo Walters
Publikováno v:
Immunology. 125:480-491
CD8(+) T cells (T(CD8+)) differentiate into effector cells following recognition of specific peptide-major histocompatibility complex (MHC) class I complexes (pMHC-I) on the surface of professional APCs (pAPCs), such as dendritic cells. Antigenic pMH
Autor:
William Reiley, Minying Zhang, Xuefeng Wu, Eric F. Tewalt, Christopher C. Norbury, Timothy O. Leonard, Ato Wright, Wei Jin, Shao Cong Sun, Andrew J. Lee, Leo R. Fitzpatrick
Publikováno v:
The Journal of Experimental Medicine
The deubiquitinating enzyme CYLD has recently been implicated in the regulation of signal transduction, but its physiological function and mechanism of action are still elusive. In this study, we show that CYLD plays a pivotal role in regulating T ce
Autor:
Roland S. Liblau, J. David Peske, Jacob D. Eccles, Sherin J. Rouhani, Jarish N. Cohen, Priscila Riccardi, Taija Makinen, Eric F. Tewalt, Victor H. Engelhard
Publikováno v:
Nature Communications
Lymphatic endothelial cells (LECs) directly express peripheral tissue antigens and induce CD8 T-cell deletional tolerance. LECs express MHC-II molecules, suggesting they might also tolerize CD4 T cells. We demonstrate that when β-galactosidase (β-g