Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Eric F Joyce"'
Autor:
Jennifer M Luppino, Andrew Field, Son C Nguyen, Daniel S Park, Parisha P Shah, Richard J Abdill, Yemin Lan, Rebecca Yunker, Rajan Jain, Karen Adelman, Eric F Joyce
Publikováno v:
PLoS Genetics, Vol 18, Iss 11, p e1010528 (2022)
The relationship between cohesin-mediated chromatin looping and gene expression remains unclear. NIPBL and WAPL are two opposing regulators of cohesin activity; depletion of either is associated with changes in both chromatin folding and transcriptio
Externí odkaz:
https://doaj.org/article/6f10829c89194c2f98ca805aea9865a4
Publikováno v:
eLife, Vol 8 (2019)
The formation and spatial arrangement of chromosome territories (CTs) in interphase has been posited to influence the outcome and frequency of genomic translocations. This is supported by correlations between the frequency of inter-chromosomal contac
Externí odkaz:
https://doaj.org/article/c2ddfdb787284ac58cedea321fd36ae2
Autor:
Andrey Poleshko, Cheryl L Smith, Son C Nguyen, Priya Sivaramakrishnan, Karen G Wong, John Isaac Murray, Melike Lakadamyali, Eric F Joyce, Rajan Jain, Jonathan A Epstein
Publikováno v:
eLife, Vol 8 (2019)
Cell-type-specific 3D organization of the genome is unrecognizable during mitosis. It remains unclear how essential positional information is transmitted through cell division such that a daughter cell recapitulates the spatial genome organization of
Externí odkaz:
https://doaj.org/article/c643add60c814c8f8717b69f653b18d6
Autor:
Milad Mokhtaridoost, Jordan J. Chalmers, Marzieh Soleimanpoor, Brandon J. McMurray, Daniella F. Lato, Son C. Nguyen, Viktoria Musienko, Joshua O. Nash, Sergio Espeso-Gil, Sameen Ahmed, Kate Delfosse, Jared W. L. Browning, A. Rasim Barutcu, Michael D. Wilson, Thomas Liehr, Adam Shlien, Samin Aref, Eric F. Joyce, Anja Weise, Philipp G. Maass
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Non-homologous chromosomal contacts (NHCCs) between different chromosomes participate considerably in gene and genome regulation. Due to analytical challenges, NHCCs are currently considered as singular, stochastic events, and their extent a
Externí odkaz:
https://doaj.org/article/ac9565cd1a404b17b3b13e344b9a0a2f
Publikováno v:
PLoS Genetics, Vol 14, Iss 7, p e1007393 (2018)
Metazoan chromosomes are folded into discrete sub-nuclear domains, referred to as chromosome territories (CTs). The molecular mechanisms that underlie the formation and maintenance of CTs during the cell cycle remain largely unknown. Here, we have de
Externí odkaz:
https://doaj.org/article/25a82e37d8194d09b65c4437ea04740f
Publikováno v:
PLoS Genetics, Vol 12, Iss 8, p e1006169 (2016)
Following DNA replication, sister chromatids must stay connected for the remainder of the cell cycle in order to ensure accurate segregation in the subsequent cell division. This important function involves an evolutionarily conserved protein complex
Externí odkaz:
https://doaj.org/article/f07dafc491d0478086116b2f4a4e31c7
Publikováno v:
PLoS Genetics, Vol 9, Iss 12, p e1004013 (2013)
Homolog pairing, which plays a critical role in meiosis, poses a potential risk if it occurs in inappropriate tissues or between nonallelic sites, as it can lead to changes in gene expression, chromosome entanglements, and loss-of-heterozygosity due
Externí odkaz:
https://doaj.org/article/121073eeb901426fadf8d7cc49097536
Publikováno v:
PLoS Genetics, Vol 8, Iss 5, p e1002667 (2012)
The pairing of homologous chromosomes is a fundamental feature of the meiotic cell. In addition, a number of species exhibit homolog pairing in nonmeiotic, somatic cells as well, with evidence for its impact on both gene regulation and double-strand
Externí odkaz:
https://doaj.org/article/7e71efaea6ca4903bbcd5f8d582ff00b
Autor:
Eric F Joyce, Kim S McKim
Publikováno v:
PLoS Genetics, Vol 6, Iss 8 (2010)
Crossovers mediate the accurate segregation of homologous chromosomes during meiosis. The widely conserved pch2 gene of Drosophila melanogaster is required for a pachytene checkpoint that delays prophase progression when genes necessary for DSB repai
Externí odkaz:
https://doaj.org/article/349953d1055541d2b59f5de44afe92db
Autor:
Li-Hsin Chang, Sourav Ghosh, Andrea Papale, Jennifer M. Luppino, Mélanie Miranda, Vincent Piras, Jéril Degrouard, Joanne Edouard, Mallory Poncelet, Nathan Lecouvreur, Sébastien Bloyer, Amélie Leforestier, Eric F. Joyce, David Holcman, Daan Noordermeer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Topologically Associating Domains (TADs) separate vertebrate genomes into insulated regulatory neighborhoods that focus genome-associated processes. TADs are formed by Cohesin-mediated loop extrusion, with many TAD boundaries consisting of c
Externí odkaz:
https://doaj.org/article/d7ed2d10c49f4258b3c6387c6f687e4e