Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Eric E. Xu"'
Autor:
Alex Z. Kadhim, Ben Vanderkruk, Samantha Mar, Meixia Dan, Katarina Zosel, Eric E. Xu, Rachel J. Spencer, Shugo Sasaki, Xuanjin Cheng, Shannon L. J. Sproul, Thilo Speckmann, Cuilan Nian, Robyn Cullen, Rocky Shi, Dan S. Luciani, Bradford G. Hoffman, Stefan Taubert, Francis C. Lynn
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Mediator, a co-regulator complex required for RNA Polymerase II activity, interacts with tissue-specific transcription factors to regulate development and maintain homeostasis. We observe reduced Mediator subunit MED15 expression in endocrin
Externí odkaz:
https://doaj.org/article/a99eab33e6ef46a1bcc1575a5001e336
Autor:
Shugo Sasaki, Cuilan Nian, Eric E. Xu, Daniel J. Pasula, Helena Winata, Sanya Grover, Dan S. Luciani, Francis C. Lynn
Publikováno v:
iScience, Vol 26, Iss 8, Pp 107311- (2023)
Summary: Restoring functional β cell mass is a potential therapy for those with diabetes. However, the pathways regulating β cell mass are not fully understood. Previously, we demonstrated that Sox4 is required for β cell proliferation during pred
Externí odkaz:
https://doaj.org/article/4b4e9944c9d2462ca5dbfa7c24f73e0c
Autor:
Nicole A.J. Krentz, Michelle Y.Y. Lee, Eric E. Xu, Shannon L.J. Sproul, Alexandra Maslova, Shugo Sasaki, Francis C. Lynn
Publikováno v:
Stem Cell Reports, Vol 11, Iss 6, Pp 1551-1564 (2018)
Summary: Human embryonic stem cells (hESCs) are a potential unlimited source of insulin-producing β cells for diabetes treatment. A greater understanding of how β cells form during embryonic development will improve current hESC differentiation pro
Externí odkaz:
https://doaj.org/article/8dda97f56d30446cac528e838ad13e90
Autor:
Shugo Sasaki, Cuilan Nian, Eric E. Xu, Daniel J. Pasula, Helena Winata, Sanya Grover, Dan S. Luciani, Francis C. Lynn
ObjectiveDiabetes onset is accompanied with β-cell deficiency, and thus restoring functional β-cell mass is a promising therapy for those with diabetes. However, the regulatory mechanisms controlling β-cell mass are not fully understood. Previousl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbb725225f32dfb659cbd0f108cd8ac6
https://doi.org/10.1101/2022.12.23.521810
https://doi.org/10.1101/2022.12.23.521810
Autor:
Daven C. Tai, Amanda M. Henderson, Angela M. Devlin, C. Bruce Verchere, Timothy J. Green, Rika E. Aleliunas, Abeer M. Aljaadi, Melissa B. Glier, Joshua W. Miller, Eric E. Xu
Publikováno v:
The FASEB Journal. 32:5039-5050
Epidemiologic studies have reported relationships between maternal high folate and/or low B12 status during pregnancy and greater adiposity and insulin resistance in children. The goal of this study was to determine the effects of maternal folic acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ecab9bd5f1ee2b6ed2743dd92ed7065
https://doi.org/10.1096/fj.201701503rr
https://doi.org/10.1096/fj.201701503rr
Publikováno v:
Diabetes. 66:2213-2219
The high-mobility group box transcription factor SOX4 is the most highly expressed SOX family protein in pancreatic islets, and mutations in Sox4 are associated with an increased risk of developing type 2 diabetes. We used an inducible β-cell knocko
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d1a097ef08d4c9cfadde801fb0e0095
https://doi.org/10.2337/db16-1074
https://doi.org/10.2337/db16-1074
Publikováno v:
The FASEB Journal. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c970210aa954edbe751647477eafa9b
https://doi.org/10.1096/fasebj.2019.33.1_supplement.779.42
https://doi.org/10.1096/fasebj.2019.33.1_supplement.779.42
Autor:
Kyung-Mee Moon, Yong Fan, Martijn van de Bunt, Eric E. Xu, Christoph H. Borchers, Majid Mojibian, Leonard J. Foster, Sunita Sinha, Juan Fernández-Tajes, Melissa M. Page, Marta Szabat, Søs Skovsø, Jason T. C. Lee, Jun Han, Farnaz Taghizadeh, Evgeniy Panzhinskiy, Shannon O'Dwyer, Timothy J. Kieffer, Massimo Trucco, Corey Nislow, Jennifer E. Bruin, Francis C. Lynn, Michael J. Bround, James D. Johnson
Publikováno v:
Cell Metabolism. 23:179-193
Pancreatic β cells are mostly post-mitotic, but it is unclear what locks them in this state. Perturbations including uncontrolled hyperglycemia can drive β cells into more pliable states with reduced cellular insulin levels, increased β cell proli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d04791981c4de6dac17da98031e471d
https://doi.org/10.1016/j.cmet.2015.10.016
https://doi.org/10.1016/j.cmet.2015.10.016
Autor:
Amanda M, Henderson, Daven C, Tai, Rika E, Aleliunas, Abeer M, Aljaadi, Melissa B, Glier, Eric E, Xu, Joshua W, Miller, C Bruce, Verchere, Tim J, Green, Angela M, Devlin
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 32(9)
Epidemiologic studies have reported relationships between maternal high folate and/or low B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8345ab4a1b842d6bbedd3d74139ace17
https://pubmed.ncbi.nlm.nih.gov/29913560
https://pubmed.ncbi.nlm.nih.gov/29913560
Autor:
Eric E. Xu, Francis C. Lynn, Sam Z. Chow, Nicole A.J. Krentz, Cuilan Nian, Mei Tang, Sara Tan
Publikováno v:
Diabetologia. 58(5)
The sex-determining region Y (SRY)-related high mobility group (HMG) box (SOX) family of transcription factors is essential for normal organismal development. Despite the longstanding knowledge that many SOX family members are expressed during pancre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdcb666b1ecbb7c0e2e105aa1c4efc77
https://pubmed.ncbi.nlm.nih.gov/25733380
https://pubmed.ncbi.nlm.nih.gov/25733380