Emergence of noise-induced oscillations in the central circadian pacemaker.

Autor: Caroline H Ko, Yujiro R Yamada, David K Welsh, Ethan D Buhr, Andrew C Liu, Eric E Zhang, Martin R Ralph, Steve A Kay, Daniel B Forger, Joseph S Takahashi

Publikováno v: PLoS Biology, Vol 8, Iss 10, p e1000513 (2010)

Bmal1 is an essential transcriptional activator within the mammalian circadian clock. We report here that the suprachiasmatic nucleus (SCN) of Bmal1-null mutant mice, unexpectedly, generates stochastic oscillations with periods that overlap the circa

Externí odkaz: https://doaj.org/article/20681a20116348f28b3deda1a36a0b56

Diurnal oscillations of endogenous H2O2 sustained by p66Shc regulate circadian clocks

Autor: Jia-Hua Qu, Na Liu, Hou-Zao Chen, Shen-Shen Cui, Xiao-Man Wang, Ji-Min Cao, Kate S. Carroll, Qian Gao, Yang Zhang, Dapeng Ju, De-Pei Liu, Xun-Kai Li, Eric E. Zhang, Wen-Qi Li, Jia-Qi Fu, Jing Yang, Xiang Zhao, De-Long Hao, Jian-Fei Pei

Publikováno v: Nature Cell Biology. 21:1553-1564

Redox balance, an essential feature of healthy physiological steady states, is regulated by circadian clocks, but whether or how endogenous redox signalling conversely regulates clockworks in mammals remains unknown. Here, we report circadian rhythms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3467807b3894ce4a0b88a068ca1a6ccc
https://doi.org/10.1038/s41556-019-0420-4

Guidelines for Genome-Scale Analysis of Biological Rhythms

Autor: Achim Kramer, Karl Kornacker, Justin Blau, Susan S. Golden, Samuel S. C. Rund, Michael H. Hastings, Han Wang, Joanna C. Chiu, Pierre Baldi, Andrew J. Millar, David Gatfield, Tanya L. Leise, Christy Hoffmann, María Teresa Camacho Olmedo, Scott Sherrill-Mix, Derk-Jan Dijk, Debra J. Skene, Jason P. DeBruyne, Hanspeter Herzel, Charles J. Weitz, Gad Asher, Jiajia Li, Katja A. Lamia, Francis J. Doyle, John B. Hogenesch, Tomasz Zielinski, Stacey L. Harmer, Xiaodong Li, Jacob J. Hughey, Christian I. Hong, Zheng Chen, Michael Rosbash, Jennifer J. Loros, Maria S. Robles, Jennifer M. Hurley, Jerome S. Menet, Scott A. Lewis, Karyn A. Esser, Juergen Cox, M. Fernanda Ceriani, Ying-Hui Fu, Joseph S. Takahashi, Ying Xu, Hiroki R. Ueda, Giles E. Duffield, Garret A. FitzGerald, Michael E. Hughes, Deborah Bell-Pedersen, Carl Hirschie Johnson, Marc D. Ruben, Felix Naef, Paul de Goede, Amita Sehgal, Horacio O. de la Iglesia, Akhilesh B. Reddy, Alaaddin Bulak Arpat, Todd C. Mockler, Emi Nagoshi, Dmitri A. Nusinow, Luciano DiTacchio, Gang Wu, Lauren J. Francey, John Harer, Steve A. Kay, Charissa de Bekker, Aziz Sancar, Ron C. Anafi, Katherine C. Abruzzi, Seung Hee Yoo, Kai-Florian Storch, Nobuya Koike, Daniel B. Forger, Erik D. Herzog, Andrew C. Liu, Louis J. Ptáček, Carla B. Green, Michael W. Young, Michael N. Nitabach, Eric E. Zhang, Jay C. Dunlap, Alexander M. Crowell, Tami A. Martino, Frédéric Gachon, Ravi Allada, Pål O. Westermark, Till Roenneberg, Martha Merrow, Herman Wijnen, Kristin Eckel-Mahan, Steve Brown, Jeff Haspel, Paolo Sassone-Corsi, David A. Rand

Publikováno v: Journal of Biological Rhythms, vol. 32, no. 5, pp. 380-393
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Journal of biological rhythms, 32(5), 380-393. SAGE Publications Inc.
Journal of Biological Rhythms
Hughes, M E, Abruzzi, K C, Allada, R, Anafi, R, Arpat, A B, Asher, G, Baldi, P, de Bekker, C, Bell-Pedersen, D, Blau, J, Brown, S, Ceriani, M F, Chen, Z, Chiu, J C, Cox, J, Crowell, A M, DeBruyne, J P, Dijk, D-J, DiTacchio, L, Doyle, F J, Duffield, G E, Dunlap, J C, Eckel-Mahan, K, Esser, K A, FitzGerald, G A, Forger, D B, Francey, L J, Fu, Y-H, Gachon, F, Gatfield, D, de Goede, P, Golden, S S, Green, C, Harer, J, Harmer, S, Haspel, J, Hastings, M H, Herzel, H, Herzog, E D, Hoffmann, C, Hong, C, Hughey, J J, Hurley, J M, de la Iglesia, H O, Johnson, C, Kay, S A, Koike, N, Kornacker, K, Kramer, A, Lamia, K, Leise, T, Lewis, S A, Li, J, Li, X, Liu, A C, Loros, J J, Martino, T A, Menet, J S, Merrow, M, Millar, A J, Mockler, T, Naef, F, Nagoshi, E, Nitabach, M N, Olmedo, M, Nusinow, D A, Ptáček, L J, Rand, D, Reddy, A B, Robles, M S, Roenneberg, T, Rosbash, M, Ruben, M D, Rund, S S C, Sancar, A, Sassone-Corsi, P, Sehgal, A, Sherrill-Mix, S, Skene, D J, Storch, K-F, Takahashi, J S, Ueda, H R, Wang, H, Weitz, C, Westermark, P O, Wijnen, H, Xu, Y, Wu, G, Yoo, S-H, Young, M, Zhang, E E, Zielinski, T & Hogenesch, J B 2017, ' Guidelines for Genome-Scale Analysis of Biological Rhythms ', Journal of biological rhythms, vol. 32, no. 5, 748730417728663, pp. 380-393 . https://doi.org/10.1177/0748730417728663
Hughes, ME; Abruzzi, KC; Allada, R; Anafi, R; Arpat, AB; Asher, G; et al.(2017). Guidelines for Genome-Scale Analysis of Biological Rhythms. Journal of Biological Rhythms, 32(5), 380-393. doi: 10.1177/0748730417728663. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/2dq117tj
Journal of biological rhythms, 32(5): 380-393

Genome biology approaches have made enormous contributions to our understanding of biological rhythms, particularly in identifying outputs of the clock, including RNAs, proteins, and metabolites, whose abundance oscillates throughout the day. These m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98132f5b6879e2975b22c568261f17f7
https://doi.org/10.1177/0748730417728663

Reciprocal Regulation between the Circadian Clock and Hypoxia Signaling at the Genome Level in Mammals

Autor: Na Liu, Huanwei Huang, Peihao Chen, Eric E. Zhang, Yang Li, Dingbin Tang, Xiangbing Qi, Yaling Wu, Wei Xiong, Zhixiong Ma, Haijiao Zhao

Publikováno v: Cell Metabolism. 25:73-85

Circadian regulation is critically important in maintaining metabolic and physiological homeostasis. However, little is known about the possible influence of the clock on physiological abnormalities occurring under pathological conditions. Here, we r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e642bb628541f1c6a7bc5b8cdff47567
https://doi.org/10.1016/j.cmet.2016.09.009

In Vivo Monitoring of Circadian Clock Gene Expression in the Mouse Suprachiasmatic Nucleus Using Fluorescence Reporters

Autor: Cheng Zhan, Eric E. Zhang, Long Mei

Publikováno v: Journal of Visualized Experiments.

This technique combines optical fiber mediated fluorescence recordings with the precise delivery of recombinant adeno-associated virus based gene reporters. This new and easy to use in vivo fluorescence monitoring system was developed to record the t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a1d50b6e97d5e15b465d896ab4f4396
https://doi.org/10.3791/56765