Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Eric D. de Groh"'
Autor:
Marc A. Wolman, Eric D. de Groh, Sean M. McBride, Thomas A. Jongens, Michael Granato, Jonathan A. Epstein
Publikováno v:
Cell Reports, Vol 8, Iss 5, Pp 1265-1270 (2014)
Neurofibromatosis type 1 (NF1) is a common autosomal-dominant disorder associated with attention deficits and learning disabilities. The primary known function of neurofibromin, encoded by the NF1 gene, is to downregulate Ras activity. We show that n
Externí odkaz:
https://doaj.org/article/e2c3996ef65144b78d4e5d56287876a0
Autor:
Jimann Shin, Arun Padmanabhan, Eric D. de Groh, Jeong-Soo Lee, Sam Haidar, Suzanne Dahlberg, Feng Guo, Shuning He, Marc A. Wolman, Michael Granato, Nathan D. Lawson, Scot A. Wolfe, Seok-Hyung Kim, Lilianna Solnica-Krezel, John P. Kanki, Keith L. Ligon, Jonathan A. Epstein, A. Thomas Look
Publikováno v:
Disease Models & Mechanisms, Vol 5, Iss 6, Pp 881-894 (2012)
SUMMARY Neurofibromatosis type 1 (NF1) is a common, dominantly inherited genetic disorder that results from mutations in the neurofibromin 1 (NF1) gene. Affected individuals demonstrate abnormalities in neural-crest-derived tissues that include hyper
Externí odkaz:
https://doaj.org/article/1d0591a3f600428693a84c8528b4fe79
Autor:
Shuning He, Marc R Mansour, Mark W Zimmerman, Dong Hyuk Ki, Hillary M Layden, Koshi Akahane, Evisa Gjini, Eric D de Groh, Antonio R Perez-Atayde, Shizhen Zhu, Jonathan A Epstein, A Thomas Look
Publikováno v:
eLife, Vol 5 (2016)
Earlier reports showed that hyperplasia of sympathoadrenal cell precursors during embryogenesis in Nf1-deficient mice is independent of Nf1’s role in down-modulating RAS-MAPK signaling. We demonstrate in zebrafish that nf1 loss leads to aberrant ac
Externí odkaz:
https://doaj.org/article/5441f057e8b24f8894e688432b587875
Autor:
Amanda D Yzaguirre, Arun Padmanabhan, Eric D de Groh, Kurt A Engleka, Jun Li, Nancy A Speck, Jonathan A Epstein
Publikováno v:
eLife, Vol 4 (2015)
Type I neurofibromatosis (NF1) is caused by mutations in the NF1 gene encoding neurofibromin. Neurofibromin exhibits Ras GTPase activating protein (Ras-GAP) activity that is thought to mediate cellular functions relevant to disease phenotypes. Loss o
Externí odkaz:
https://doaj.org/article/27d46286b9ea495bb6740aa413f93f2b
Autor:
Jonathan A. Epstein, Marc A. Wolman, Sean M.J. McBride, Thomas A. Jongens, Michael Granato, Eric D de Groh
Publikováno v:
Cell Reports, Vol 8, Iss 5, Pp 1265-1270 (2014)
Cell reports
Cell reports
Summary Neurofibromatosis type 1 (NF1) is a common autosomal-dominant disorder associated with attention deficits and learning disabilities. The primary known function of neurofibromin, encoded by the NF1 gene, is to downregulate Ras activity. We sho
Autor:
Hillary M. Layden, Jonathan A. Epstein, Dong Hyuk Ki, Shuning He, A. Thomas Look, Antonio R. Perez-Atayde, Koshi Akahane, Evisa Gjini, Eric D de Groh, Shizhen Zhu, Marc R. Mansour, Mark W. Zimmerman
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5df70db42c010c740379ac50d245070e
https://doi.org/10.7554/elife.14713.017
https://doi.org/10.7554/elife.14713.017
Autor:
Jonathan A. Epstein, Mark W. Zimmerman, Koshi Akahane, Marc R. Mansour, Shizhen Zhu, Dong Hyuk Ki, Shuning He, Hillary M. Layden, Eric D de Groh, Evisa Gjini, Antonio R. Perez-Atayde, A. Thomas Look
Publikováno v:
eLife
eLife, Vol 5 (2016)
eLife, Vol 5 (2016)
Earlier reports showed that hyperplasia of sympathoadrenal cell precursors during embryogenesis in Nf1-deficient mice is independent of Nf1’s role in down-modulating RAS-MAPK signaling. We demonstrate in zebrafish that nf1 loss leads to aberrant ac
Autor:
Rachel L. Jackson, Billy W. Day, Weixiang Dai, Carolyn A. Kitchens, Neil A. Hukriede, Chiara Cianciolo Cosentino, Eric D. de Groh, Thomas E. Smithgall, Lisa M. Swanhart
Publikováno v:
Journal of the American Society of Nephrology. 21:794-802
One of the first hallmarks of kidney regeneration is the reactivation of genes normally required during organogenesis. Identification of chemicals with the potential to enhance this reactivation could therapeutically promote kidney regeneration. Here
Autor:
Neil A. Hukriede, Amanda L. Garner, Eric D. de Groh, Fengling Song, Valerie D. Mitchell, Lance A. Davidson, Kazunori Koide
Publikováno v:
ChemBioChem. 9:214-218
Fluorescent imaging is becoming an increasingly important technology for examining the real-time localizations of biologically relevant molecules within model organisms such as the zebrafish. Such imaging often requires the use of 2′,7′-dichlorof