Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Eric D. Zhu"'
Publikováno v:
Endocrinology. 155:1188-1196
Bisphosphonates are effective for preventing and treating skeletal disorders associated with hyperresorption. Their safety and efficacy has been studied in adults where the growth plate is fused and there is no longitudinal bone growth and little app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40de7e3a684231ccebba36ce5ffeb997
https://doi.org/10.1210/en.2013-1993
https://doi.org/10.1210/en.2013-1993
Publikováno v:
Journal of Bone and Mineral Research. 25:2504-2514
Wdr5, a bone morphogenetic protein 2 (BMP-2)-induced protein belonging to the family of the WD repeat proteins, is expressed in proliferating and hypertrophic chondrocytes of the growth plate and in osteoblasts. Although previous studies have provide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54f825e20cf02cbf495d882ecb5b6f6f
https://doi.org/10.1002/jbmr.144
https://doi.org/10.1002/jbmr.144
Publikováno v:
Journal of Biological Chemistry. 285:18270-18275
Growth plate abnormalities, associated with impaired hypertrophic chondrocyte apoptosis, are observed in humans and animals with abnormalities of vitamin D action and renal phosphate reabsorption. Low circulating phosphate levels impair hypertrophic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a32c9c585b90f01849d3a083dab81b7a
https://doi.org/10.1074/jbc.m109.098616
https://doi.org/10.1074/jbc.m109.098616
Autor:
Francesca Gori, Eva S. Liu, Byongsoo Timothy Chae, Marie B. Demay, Alena A. Zalutskaya, Eric D. Zhu
Publikováno v:
Endocrinology. 155(10)
Phosphate and parathyroid hormone related peptide (PTHrP) are required for normal growth plate maturation. Hypophosphatemia impairs hypertrophic chondrocyte apoptosis leading to rachitic expansion of the growth plate; however, the effect of phosphate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ab256e77b4c1182651aafb1d9b40f28
https://pubmed.ncbi.nlm.nih.gov/25057796
https://pubmed.ncbi.nlm.nih.gov/25057796
Publikováno v:
Endocrinology. 154(1)
The vitamin D receptor (VDR) has both 1,25-dihydroxyvitamin D-dependent and -independent actions in the epidermis. Ligand-dependent actions of the VDR have been shown to promote keratinocyte differentiation and to regulate formation of the epidermal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d886b011fd338c6e742d9590e7b2e3f
https://pubmed.ncbi.nlm.nih.gov/23132743
https://pubmed.ncbi.nlm.nih.gov/23132743
Publikováno v:
Endocrinology. 151(10)
Rickets is a growth plate abnormality observed in growing animals and humans. Rachitic expansion of the hypertrophic chondrocyte layer of the growth plate, in the setting of hypophosphatemia, is due to impaired apoptosis of these cells. Rickets is ob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19123a3e8156e96abf465ee9b8432bfb
https://pubmed.ncbi.nlm.nih.gov/20858767
https://pubmed.ncbi.nlm.nih.gov/20858767
Wdr5 is developmentally expressed in osteoblasts and is required for osteoblast differentiation. Mice overexpressing Wdr5 under the control of the mouse α(1)I collagen promoter (Col I-Wdr5) display accelerated osteoblast differentiation as well as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a97da5e7ba7a703f0254c22ce939c7ff
https://europepmc.org/articles/PMC2670346/
https://europepmc.org/articles/PMC2670346/
Publikováno v:
The Journal of biological chemistry. 283(12)
Wdr5 is developmentally expressed in osteoblasts and accelerates osteoblast differentiation in vitro and in vivo. To address whether Wdr5 is essential for osteoblast differentiation, plasmid-based small interfering RNAs were used to stably suppress e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c09a96be68bf3fb34762b6b6b0eb7041
https://pubmed.ncbi.nlm.nih.gov/18201971
https://pubmed.ncbi.nlm.nih.gov/18201971