Výsledky vyhledávání - "Eric D. Tomhave"

Cross-desensitization of Chemoattractant Receptors Occurs at Multiple Levels

Autor: Bodduluri Haribabu, Eric D. Tomhave, Hydar Ali, Ricardo M. Richardson, Ralph Snyderman

Publikováno v: Journal of Biological Chemistry. 270:27829-27833

To define the molecular mechanisms of cross-regulation among chemoattractant receptors, we stably co-expressed, in a rat basophilic leukemia (RBL-2H3) cell line, epitope-tagged receptors for the chemoattractants formylmethionylleucylphenylalanine (fM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::621de73664697169d222241f0315eed8
https://doi.org/10.1074/jbc.270.46.27829

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Regulation of Human Interleukin-8 Receptor A: Identification of a Phosphorylation Site Involved in Modulating Receptor Functions

Autor: Bodduluri Haribabu, Ricardo M. Richardson, Hydar Ali, Robert A. DuBose, Ralph Snyderman, Eric D. Tomhave

Publikováno v: Biochemistry. 34:14193-14201

The human type A interleukin-8 receptor (IL-8RA) was modified to express an amino-terminal epitope tag and stably overexpressed in a rat basophilic leukemia cell line (RBL-2H3). This receptor (ET-IL-8RA) displayed functional properties similar to tho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82b9781123a033469efc1b51f017c782
https://doi.org/10.1021/bi00043a025

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Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase

Autor: E G Goldstein, Ralph Snyderman, Sara S. Hook, Bodduluri Haribabu, Arthur M. Edelman, Anthony R. Means, M A Selbert, Eric D. Tomhave

Publikováno v: The EMBO Journal. 14:3679-3686

Human Ca(2+)-calmodulin (CaM) dependent protein kinase I (CaMKI) encodes a 370 amino acid protein with a calculated M(r) of 41,337. The 1.5 kb CaMKI mRNA is expressed in many different human tissues and is the product of a single gene located on huma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::948d1f84377858f7abc563f7b64b07d4
https://doi.org/10.1002/j.1460-2075.1995.tb00037.x

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Regulation of stably transfected platelet activating factor receptor in RBL-2H3 cells. Role of multiple G proteins and receptor phosphorylation

Autor: Eric D. Tomhave, Hydar Ali, Ralph Snyderman, Bodduluri Haribabu, R. A. Dubose, Ricardo M. Richardson

Publikováno v: Journal of Biological Chemistry. 269:24557-24563

Platelet activating factor (PAF) interacts with cell surface receptors to mediate inflammatory responses. To determine the mechanisms of PAF receptor regulation, we constructed epitope-tagged human PAF receptor cDNA (ET-PAFR) and generated stable tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::94c9a071bb5ccc41c4fe65263405238c
https://doi.org/10.1016/s0021-9258(17)31428-x

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Differences in phosphorylation of formylpeptide and C5a chemoattractant receptors correlate with differences in desensitization

Autor: Ricardo M. Richardson, John R. Didsbury, Ralph Snyderman, Hydar Ali, Eric D. Tomhave

Publikováno v: Journal of Biological Chemistry. 268:24247-24254

To define the regulation of chemoattractant receptors, epitope-tagged human formyl peptide and C5a receptor cDNAs (ET-FR and ET-C5aR) were stably expressed in rat basophilic leukemia, RBL-2H3 cells. An antibody (12CA5) specific to "ET" was used to im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::76281e4f5a237185c723784cc4025187
https://doi.org/10.1016/s0021-9258(20)80517-1

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Functional high efficiency expression of cloned leucocyte chemoattractant receptor cDNAs

Autor: Eric D. Tomhave, Jolin R. Didsbury, Craig Gerard, Norma P. Gerard, Ronald J. Uhing, Ralph Snyderman

Publikováno v: FEBS Letters. 297:275-279

Human kidney 293 TSA cells were transfected by a calcium phosphate method with human formylpeptide and C5a receptor cDNAs with high efficiency. Formylpeptide receptor positive transfectants expressed a total of 968,000 +/- 34,000 receptors per cell w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec9f7a1170ecd596ef104a3ed8b82bc2
https://doi.org/10.1016/0014-5793(92)80555-u

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Receptor class desensitization of leukocyte chemoattractant receptors

Autor: Norma P. Gerard, Ralph Snyderman, John R. Didsbury, Ronald J. Uhing, Eric D. Tomhave, Craig Gerard

Publikováno v: Proceedings of the National Academy of Sciences. 88:11564-11568

To better define their regulation, formylpeptide and C5a chemoattractant receptor cDNAs were transiently expressed with high efficiency (approximately 35-54%) in human kidney cells. As in neutrophils, both receptors were active in elevating intracell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b437209fd0bfdbcfb9ce693e1bcf1c66
https://doi.org/10.1073/pnas.88.24.11564

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Myocardial overexpression of GRK3 in transgenic mice: evidence for in vivo selectivity of GRKs

Autor: Walter J. Koch, Eric D. Tomhave, Kyle F. Shotwell, Guido Iaccarino, Howard A. Rockman

Publikováno v: Scopus-Elsevier

Transgenic mice were generated with cardiac-specific overexpression of the G protein-coupled receptor kinase 3 (GRK3) to explore the in vivo role of this GRK in cardiac function. GRK3 is expressed in the heart along with the beta-adrenergic receptor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d66caa0e0f8765c3fa162b720b46b92
https://pubmed.ncbi.nlm.nih.gov/9746479

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