Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Eric D. Sun"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Dimension reduction is an indispensable part of modern data science, and many algorithms have been developed. Here, the authors develop a theoretically justified, simple to use and reliable spectral method to assess and combine multiple dimension red
Externí odkaz:
https://doaj.org/article/1522a1fe8d724713a94955fba6e99e92
Autor:
Matthew T. Buckley, Eric D. Sun, Benson M. George, Ling Liu, Nicholas Schaum, Lucy Xu, Jaime M. Reyes, Margaret A. Goodell, Irving L. Weissman, Tony Wyss-Coray, Thomas A. Rando, Anne Brunet
Publikováno v:
Nature aging, vol 3, iss 1
The diversity of cell types is a challenge for quantifying aging and its reversal. Here we develop ‘aging clocks’ based on single-cell transcriptomics to characterize cell-type-specific aging and rejuvenation. We generated single-cell transcripto
Spatial transcriptomics capture high-resolution spatial distributions of RNA transcripts within biological systems, yet whole-transcriptome profiling of genes at single-cell resolution remains a challenge. To address this limitation, spatial gene exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fbf85c74baddf2d7f5d08e32889c6ce
https://doi.org/10.1101/2023.04.25.538326
https://doi.org/10.1101/2023.04.25.538326
Autor:
Jian Kang, Francesco Cucca, Brian H. Chen, Thomas J. Butler, Stefania Bandinelli, Jun Ding, Ilya G. Goldberg, Carlo Sidore, Toshiko Tanaka, Gonçalo R. Abecasis, Eric D. Sun, Jesse Zhao, Myriam Gorospe, Richard Oppong, Yong Qian, Luigi Ferrucci, David Schlessinger
Publikováno v:
Aging (Albany NY)
It is widely thought that individuals age at different rates. A method that measures “physiological age” or physiological aging rate independent of chronological age could therefore help elucidate mechanisms of aging and inform an individual’s
Dimensionality reduction (DR) is commonly used to project highdimensional data into lower dimensions for visualization, which could then generate new insights and hypotheses. However, DR algorithms necessarily introduce distortions in the visualizati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::505f991a64d649d895e5cf5a9371e6d8
https://doi.org/10.1101/2022.05.27.493785
https://doi.org/10.1101/2022.05.27.493785
Autor:
Robin W. Yeo, Olivia Y. Zhou, Brian L. Zhong, Eric D. Sun, Paloma Navarro Negredo, Surag Nair, Mahfuza Sharmin, Tyson J. Ruetz, Mikaela Wilson, Anshul Kundaje, Alexander R. Dunn, Anne Brunet
Aging is accompanied by a deterioration in the regenerative and repair potential of stem cell niches in the brain1–5. However, the mechanisms underlying this decline are largely unknown. Here we characterize genome-wide chromatin accessibility in y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5de3fde6fda913dc192078deac9f74a0
https://doi.org/10.1101/2021.03.29.437585
https://doi.org/10.1101/2021.03.29.437585
Publikováno v:
Proc Natl Acad Sci U S A
Many complex systems experience damage accumulation, which leads to aging, manifest as an increasing probability of system collapse with time. This naturally raises the question of how to maximize health and longevity in an aging system at minimal co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::223ff407d1e0e30cfffee94b81ef4532
http://arxiv.org/abs/1910.10002
http://arxiv.org/abs/1910.10002
Autor:
Ron Dekel, Eric D. Sun
Publikováno v:
Journal of Vision
Deep neural network (DNN) models for computer vision are capable of human-level object recognition. Consequently, similarities between DNN and human vision are of interest. Here, we characterize DNN representations of Scintillating grid visual illusi