Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Eric D. Strobel"'
Autor:
Hancheng Guan, Manunya Nuth, Stuart N. Isaacs, Yuhong Xiao, Richard W. Scott, Michael H. Parker, Eric D. Strobel, John L. Kulp, Thomas R. Bailey, Allen B. Reitz, Robert P. Ricciardi
Publikováno v:
Antiviral research.
Molluscum contagiosum (MC) is an infectious disease that occurs only in humans with a tropism that is narrowly restricted to the outermost epidermal layer of the skin. Molluscum contagiosum virus (MCV) is the causative agent of MC which produces skin
Autor:
Stuart N. Isaacs, Robert P. Ricciardi, Yuhong Xiao, Allen B. Reitz, John L. Kulp, Manunya Nuth, Eric D. Strobel, Michael H. Parker, Hancheng Guan, Richard W. Scott
Publikováno v:
Antiviral Res
The smallpox virus (variola) remains a bioterrorism threat since a majority of the human population has never been vaccinated. In the event of an outbreak, at least two drugs against different targets of variola are critical to circumvent potential v
Autor:
Allen B. Reitz, Nathan G. Dolloff, Reeder M. Robinson, Haiyan Bian, Sarah L. Hyman, Eric D. Strobel, Ravyn M. Duncan, Leticia Reyes
Publikováno v:
Eur J Med Chem
Protein disulfide isomerase (PDI, PDIA1) is an emerging therapeutic target in oncology. PDI inhibitors have demonstrated a unique propensity to selectively induce apoptosis in cancer cells and overcome resistance to existing therapies, although drug
Publikováno v:
The Journal of Organic Chemistry. 70:4873-4875
The addition of small amounts of solid KCN to solution and solid-phase esters in THF/MeOH/50% aqueous NH2OH increases the efficiency of their transformation to the corresponding hydroxamic acids.
Autor:
William R. McCrea, Eric D. Strobel, Daniel A. Klein, Craig S. Runk, Sara M. Haverty, Harold W. Pinnick
Publikováno v:
Tetrahedron Letters. 33:2665-2668
Phosphorus oxychloride and pyridine convert allylic alcohols into conjugated dienes in good to excellent yields.
Autor:
George J. Yohrling, Eric D. Strobel, Yifang Huang, Chih Y. Ho, Ellen W. Baxter, Marc Vandermeeren, Richard S. Alexander, Charles H. Reynolds, Allen B. Reitz, Douglas E. Brenneman, Brett A. Tounge, H. Moore Arnold, Jennifer Piesvaux, Marc Mercken, Michael H. Parker, Kelly A. Conway, Daniel I. Rosenthal
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(10)
We have identified macrocyclic inhibitors of the aspartic protease BACE, implicated in the etiology of Alzheimer’s disease. An X-ray structure of screening hit 1 in the BACE active site revealed a hairpin conformation suggesting that constrained ma
Autor:
Jian Li, Harold R. Almond, Steven A. Middleton, Dana L. Johnson, Gregory C. Leo, Donald Ludovici, Judith Baker, Stuart Emanuel, Hwa-Kwo Yen, Robert A. Galemmo, Robert H. Gruninger, Eric D. Strobel, Ann Devine, Rose Tominovich, Chih Y. Ho, Laura Andraka, Jay Mei, Hong Lu, Umar Maharoof, Robert W. Tuman, Jan L. Sechler
Publikováno v:
Journal of medicinal chemistry. 48(26)
A series of (6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines has been optimized to preserve both potent kinase inhibition activity against the angiogenesis target, the receptor tyrosine kinase of Platelet-Derived Growth Factor-BB (PDG