Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Eric D. Spear"'
Publikováno v:
mBio, Vol 13, Iss 5 (2022)
ABSTRACT COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has had a devastating impact on global public health, emphasizing the importance of understanding innate immune mechanisms and cellular restriction fact
Externí odkaz:
https://doaj.org/article/c3bddbb4b2ae4aeaae5dc293fc31dd8b
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 7, Pp 1853-1866 (2016)
Cellular protein quality control (PQC) systems selectively target misfolded or otherwise aberrant proteins for degradation by the ubiquitin-proteasome system (UPS). How cells discern abnormal from normal proteins remains incompletely understood, but
Externí odkaz:
https://doaj.org/article/9571fcb8f00742279e74293c8a95de0a
Autor:
Eric D. Spear, Erh-Ting Hsu, Laiyin Nie, Elisabeth P. Carpenter, Christine A. Hrycyna, Susan Michaelis
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 7 (2018)
The human zinc metalloprotease ZMPSTE24 is an integral membrane protein crucial for the final step in the biogenesis of the nuclear scaffold protein lamin A, encoded by LMNA. After farnesylation and carboxyl methylation of its C-terminal CAAX motif,
Externí odkaz:
https://doaj.org/article/6c0979a4e97a4be383f99598cba015bf
Publikováno v:
Journal of Biological Chemistry. 299:102851
Misfolded proteins are recognized and degraded through protein quality control (PQC) pathways, which are essential to maintaining proteostasis and normal cellular functions. Defects in PQC can result in disease, including cancer, cardiovascular disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1686d158c81791d0ddfb1b6de33528be
https://doi.org/10.1016/j.jbc.2022.102851
https://doi.org/10.1016/j.jbc.2022.102851
Autor:
Eric D. Spear, H. J. Worman, Yuefan Wang, W. Hsu, W. Wu, C.-S. Lin, Susan Michaelis, K. Shiladardi, T. Maruyama, C. B. Damoci, T. Hsu, J.-Y. Shin, Kamsi O. Odinammadu
Prelamin A is a farnesylated precursor of lamin A, a nuclear lamina protein. Accumulation of the farnesylated prelamin A variant progerin, with an internal deletion including its processing site, causes Hutchinson-Gilford progeria syndrome. Loss of f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5507af2eaa98cfe2d228d7ebda23e7b7
https://doi.org/10.1101/2021.11.11.465186
https://doi.org/10.1101/2021.11.11.465186
Autor:
Elisabeth P. Carpenter, Timothy D. Babatz, Olivia L. Sun, Wenxin Xu, Susan Michaelis, Laiyin Nie, Eric D. Spear
Publikováno v:
The Journal of Biological Chemistry
The integral membrane zinc metalloprotease ZMPSTE24 is important for human health and longevity. ZMPSTE24 performs a key proteolytic step in maturation of prelamin A, the farnesylated precursor of the nuclear scaffold protein lamin A. Mutations in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bea20a97fc97ca35dd6bb9fdba9238b
https://pubmed.ncbi.nlm.nih.gov/33293369
https://pubmed.ncbi.nlm.nih.gov/33293369
Autor:
Susan Michaelis, Wenxin Xu, Eric D. Spear, Timothy D. Babatz, Olivia L. Sun, Laiyin Nie, Elisabeth P. Carpenter
The integral membrane zinc metalloprotease ZMPSTE24 is important for human health and longevity. ZMPSTE24 performs a key proteolytic step in maturation of prelamin A, the precursor of the nuclear scaffold protein lamin A. Mutations in the genes encod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1d52b683a393f2fc749ca7e92cbc39f
https://doi.org/10.1101/2020.08.17.254532
https://doi.org/10.1101/2020.08.17.254532
Autor:
N.A. Burgess-Brown, Bérénice Rotty, Y.Y. Dong, Susan Michaelis, Timothy D. Babatz, A. Quigley, Rod Chalk, Ashley C. W. Pike, Stephen G. Young, Elisabeth P. Carpenter, Eric D. Spear, Laiyin Nie, S.M.M. Mukhopadhyay, A. Chu
Human ZMPSTE24, an integral membrane zinc metalloprotease, is required for conversion of prelamin A to mature lamin A, a component of the nuclear lamina and failure of this processing causes premature ageing disorders. ZMPSTE24 has also been implicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d742d8b82f9250e4677be023d08454dc
Autor:
Wenxin Xu, Susan Michaelis, Eric D. Spear, Kaitlin M. Wood, Kamsi O. Odinammadu, Otto W. Mossberg
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0239269 (2020)
PLoS ONE
PLoS ONE
The integral membrane zinc metalloprotease ZMPSTE24 plays a key role in the proteolytic processing of farnesylated prelamin A, the precursor of the nuclear scaffold protein lamin A. Failure of this processing step results in the accumulation of perma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::648abedd381744d9f344a8f9751f4740
https://doaj.org/article/1f96605783564ba7a48691bdbf9508b8
https://doaj.org/article/1f96605783564ba7a48691bdbf9508b8
Autor:
Khurts Shilagardi, Rebecca F. Alford, Kaitlin M. Wood, Tim D. Babatz, Kamsi O. Odinammadu, Susan Michaelis, Jeffrey J. Gray, Otto W. Mossberg, Eric D. Spear
The nuclear lamins A, B, and C are intermediate filament proteins that form a nuclear scaffold adjacent to the inner nuclear membrane in higher eukaryotes, providing structural support for the nucleus. In the past two decades it has become evident th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c52776ab38f99d33939cc8d9eceb4f57
https://europepmc.org/articles/PMC6401292/
https://europepmc.org/articles/PMC6401292/