Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Eric D. Mortenson"'
PDF file - 45K, Supplemental Figure 1: The percentage of tumor infiltrating CD4+ cells greater than CD8+ cells. Supplemental Figure 2: Anti-CD4 depletion effectively removes CD4+ cells. Supplemental Figure 3: B cells are not required for anti-neu the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d77412ee21b569efce5a2b43ed8dfc8
https://doi.org/10.1158/1078-0432.22452023
https://doi.org/10.1158/1078-0432.22452023
Purpose: Targeting oncogenic receptors with antibodies has been thought to suppress tumor growth mainly by interrupting oncogenic signals. Recently, the essential role for adaptive immunity, and CD8+ T cells in particular, has been established as a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e945d98e9f2dffb04404b7772687a04
https://doi.org/10.1158/1078-0432.c.6522365
https://doi.org/10.1158/1078-0432.c.6522365
Publikováno v:
Clinical Cancer Research. 19:1476-1486
Purpose: Targeting oncogenic receptors with antibodies has been thought to suppress tumor growth mainly by interrupting oncogenic signals. Recently, the essential role for adaptive immunity, and CD8+ T cells in particular, has been established as a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51ad3038352ec61337381ac2cc4e71c1
https://doi.org/10.1158/1078-0432.ccr-12-2522
https://doi.org/10.1158/1078-0432.ccr-12-2522
Publikováno v:
Molecular Therapy. 21:91-100
Epidermal growth factor receptor (EGFR) over-signaling leads to more aggressive tumor growth. The antitumor effect of Cetuximab, an anti-EGFR antibody, depends on oncogenic-signal blockade leading to tumor cell apoptosis and antibody dependent cell-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93f79672e7b53beba50961bf911f8b61
https://doi.org/10.1038/mt.2012.184
https://doi.org/10.1038/mt.2012.184
Autor:
Yang Xin Fu, Eric D. Mortenson
Publikováno v:
Current Pathobiology Reports. 1:37-42
Oncogenic signaling, such as HER2/neu signaling, has been shown to play major role for tumorigenesis in a subset of breast cancer patients. The use of anti-HER2/neu antibody has not only revealed the mechanisms for HER2/neu signaling but also shown a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aaa4f836241d6c8b176937c1c78493a
https://doi.org/10.1007/s40139-012-0001-8
https://doi.org/10.1007/s40139-012-0001-8
Publikováno v:
Cellular & Molecular Immunology. 9:20-26
Tumor metastases and relapse are the major causes of morbidity and mortality in cancer. Although surgery, chemotherapy and/or radiation therapy can typically control primary tumor growth, metastatic and relapsing tumors are often inaccessible or resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::108c116ecafa6abda8915ea82181f37b
https://doi.org/10.1038/cmi.2011.49
https://doi.org/10.1038/cmi.2011.49
Autor:
Geun Am Song, Hyunkeun Song, Sun Young Ma, Jin-Hee Park, Tae Oh Kim, Sang Kyun Bae, Ki Hyaung Kim, Sae-Gwang Park, Jin-Ho Kim, Yang Xin Fu, Eric D. Mortenson, Jae-Hyug Choi, Il-Whan Choi, Su-Kil Seo, Mi Seon Kang, Tae Hyun Kim
Publikováno v:
BMC Cancer
Background Along with de novo resistance, continued exposure to trastuzumab, an anti-human epidermal growth factor receptor 2 (HER2/neu) antibody, can lead to acquired resistance. In this study, we characterize a new anti-HER2/neu antibody resistant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7b22d01843fdfe3c625d7b048c7f233
http://europepmc.org/articles/PMC4161915
http://europepmc.org/articles/PMC4161915
Autor:
Eric D. Mortenson, Karen L. Edelblum, Galina Khramtsova, H. Aimee Kwak, Jerrold R. Turner, Nora E. Joseph, Peter A. Savage, Gurminder Singh, Sam C. Nalle
Publikováno v:
Science translational medicine. 6(243)
Previous studies have shown a correlation between pretransplant conditioning intensity, intestinal barrier loss, and graft-versus-host disease (GVHD) severity. However, because irradiation and other forms of pretransplant conditioning have pleiotropi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a72d2a2b37849ccd0a6748533df9fcc
https://pubmed.ncbi.nlm.nih.gov/24990882
https://pubmed.ncbi.nlm.nih.gov/24990882
Autor:
Yang Xin Fu, Eric D. Mortenson
Publikováno v:
Oncoimmunology
Preclinical studies have established that CD8+ T cells are necessary for efficient immunotherapeutic regimens targeting v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2, best known as HER2/Neu). Recently, we extended upon these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e6f528762ec93c8fd0343a259af676a
http://europepmc.org/articles/PMC3935925
http://europepmc.org/articles/PMC3935925